Active Substance: Cimetidine.
Overview
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This medicine contains an important and useful components, as it consists of
Cimetidineis available in the market in concentration
Cimetidine
Impaired renal and hepatic function. Age >50 yr; CV impairment. Pregnancy. Lactation: enters breast milk/not recommended
Heartburn, Dyspepsia, Peptic ulcers, Benign gastric and duodenal ulceration, Gastro-oesophageal reflux disease, Zollinger-Ellison syndrome, Pancreatic insufficiency
Hypersensitivity, lactation.
1-10% Headache (2.1%),Dizziness (1%),Somnolence (1%),Gynecomastia (0.3-4%) Frequency Not Defined Confusion (elderly),Impotence,Diarrhea,Nausea,Vomiting
2
Cimetidine competitively inhibits histamine at H2-receptors of the gastric parietal cells resulting in decreased gastric acid secretion, gastric volume and hydrogen ion concentration. It is also used in patients w/ pancreatic insufficiency to reduce the breakdown of pancreatic enzyme supplements.
Reduces absorption of dasatinib, ketoconazole, itraconazole and posaconazole. May increase serum levels of phenytoin, theophylline, lidocaine, hydroxyzine and oral anticoagulants. Absorption may be reduced by antacids. Decreased bioavailability w/ metoclopramide, sucralfate or propantheline. May potentiate the myelosuppressive effects (e.g. agranulocytosis, neutropenia) of myelosuppressive drugs (e.g. antimetabolites, alkylating agents) or therapies (e.g. radiation).
Information not available