ADOL COMPOUND Tablets (Caplets)

What is ADOL COMPOUND

ADOL COMPOUND is a combination analgesic medication formulated to relieve mild to moderate pain and reduce fever. It is composed of four active ingredients: Paracetamol, Codeine, Caffeine, and Salicylamide. Each component contributes uniquely to its overall efficacy:

• Paracetamol: Acts as an analgesic and antipyretic, helping reduce pain and fever.
• Codeine: A mild opioid analgesic that enhances pain relief by acting on the central nervous system.
• Caffeine: A central nervous system stimulant that can improve the effectiveness of painkillers and reduce fatigue.
• Salicylamide: Provides analgesic and anti-inflammatory properties, complementing the other components.

Due to this combination, ADOL COMPOUND is often prescribed for various conditions such as headaches, dental pain, musculoskeletal pain, and fever associated with infections or other illnesses. Its multi-ingredient formulation allows for better pain control compared to single-ingredient analgesics, especially when symptoms are complex.

This medicine is available in tablet form, typically in packs of 20 tablets (10 tablets per blister strip, 2 strips per pack). It should be used under medical supervision, particularly because of the presence of Codeine, which is an opioid and may cause dependence or other side effects if misused.

How to use ADOL COMPOUND

Proper use of ADOL COMPOUND ensures maximum benefit while minimizing risks. Follow these guidelines carefully:

• Dosage: Always follow the prescription provided by your healthcare professional. Do not self-medicate or exceed the recommended dose.
• Administration: Take the tablet orally with a full glass of water. It can be taken with or without food; however, if you experience stomach upset, taking it with food or milk is advised.
• Frequency: Typically, the medication is taken every 4 to 6 hours as needed, but do not exceed 4 doses (tablets) within 24 hours.
• Duration: Use this medicine for the shortest time necessary to control symptoms. Prolonged use without medical supervision is not recommended.
• Special precautions: Avoid alcohol consumption while taking ADOL COMPOUND, as it may increase the risk of liver damage and enhance sedative effects of codeine.
• Missed dose: If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to catch up.
• Discontinuation: Do not abruptly stop the medication if it was prescribed for chronic pain without consulting your doctor, especially due to codeine’s potential dependence risk.

Mode of Action ADOL COMPOUND

The effectiveness of ADOL COMPOUND is based on the combined pharmacological actions of its four active ingredients working synergistically:

• Paracetamol: Primarily inhibits the enzyme cyclooxygenase (COX) in the brain, which reduces prostaglandin synthesis. Prostaglandins are chemicals involved in pain signaling and fever production, so their reduction leads to analgesic and antipyretic effects.
• Codeine: Converts in the liver to morphine, which binds to opioid receptors in the central nervous system. This binding modulates pain perception by altering the brain’s response to pain signals, providing effective relief from moderate pain.
• Caffeine: Acts as a central nervous system stimulant and enhances the analgesic effect by promoting faster absorption and better efficacy of paracetamol. It also helps counteract drowsiness caused by codeine and can improve mental alertness.
• Salicylamide: Functions as an analgesic and mild anti-inflammatory by inhibiting prostaglandin synthesis similar to non-steroidal anti-inflammatory drugs (NSAIDs). It contributes additional pain relief and helps reduce inflammation.

Together, these mechanisms allow ADOL COMPOUND to tackle pain from different pathways: peripheral inflammation, central pain processing, and enhancing alertness, making it a potent option for pain management.

ADOL COMPOUND Interactions ADOL COMPOUND

Due to its multiple components, ADOL COMPOUND can interact with various drugs, which may alter its efficacy or increase side effects. Some important interactions include:

• Other CNS depressants: Medications such as benzodiazepines, alcohol, sedatives, and other opioids may potentiate sedation and respiratory depression when taken with codeine.
• Monoamine oxidase inhibitors (MAOIs): Concurrent use can cause severe adverse effects like hypertensive crisis due to codeine and caffeine interaction.
• Warfarin and other anticoagulants: Paracetamol and salicylamide can increase the risk of bleeding, so close monitoring of coagulation parameters is advised.
• Other analgesics or NSAIDs: Combining with other painkillers like aspirin, ibuprofen, or additional acetaminophen may increase the risk of toxicity, particularly liver or kidney damage.
• Enzyme-inducing or inhibiting drugs: Drugs that affect liver enzymes (CYP450 system), such as rifampin or certain antidepressants, may alter codeine metabolism, impacting its effectiveness or side effect profile.
• Anticholinergic drugs: May increase the risk of adverse effects like constipation and urinary retention with codeine.

Always inform your healthcare provider of all medications and supplements you are taking to avoid harmful interactions.

Dosage of ADOL COMPOUND

The dosage of ADOL COMPOUND should be individualized based on the patient's age, weight, severity of symptoms, and overall health status. Typical adult dosing guidelines include:

• Adults and adolescents over 12 years: 1-2 tablets every 4 to 6 hours as needed for pain relief or fever reduction.
• Maximum daily dose: Do not exceed 8 tablets in 24 hours (considering the maximum safe dose of paracetamol and codeine components).
• Duration of treatment: Short-term use is recommended, generally not exceeding 3 days without medical review.
• Elderly patients: Use with caution and possibly reduced dose due to increased risk of side effects and altered metabolism.
• Children under 12 years: This medication is usually not recommended due to codeine's risk profile. Use only if prescribed and monitored by a doctor.

Always adhere strictly to the prescribed dose and schedule to avoid overdose or side effects, especially concerning paracetamol, which can cause liver toxicity if overdosed.

Possible side effects of ADOL COMPOUND

While ADOL COMPOUND is generally safe when used as directed, side effects can occur, ranging from mild to severe. Common and important side effects include:

• Gastrointestinal: Nausea, vomiting, constipation, stomach discomfort, and rarely gastrointestinal bleeding (due to salicylamide).
• Central Nervous System: Drowsiness, dizziness, headache, lightheadedness, especially due to codeine and caffeine.
• Allergic reactions: Rash, itching, swelling, or rarely severe hypersensitivity such as anaphylaxis.
• Respiratory: Respiratory depression (slow or shallow breathing) is a serious risk linked to codeine, especially in overdose or sensitive individuals.
• Other effects: Dependence or tolerance to codeine with prolonged use, liver toxicity (with overdose of paracetamol), and caffeine-related effects like nervousness or insomnia.

If you experience severe side effects such as difficulty breathing, severe allergic reactions, persistent stomach pain, or jaundice (yellowing of skin or eyes), seek immediate medical attention.

ADOL COMPOUND Contraindications ADOL COMPOUND

ADOL COMPOUND should not be used in certain situations where risks outweigh benefits. Contraindications include:

• Hypersensitivity: Known allergy to paracetamol, codeine, caffeine, salicylamide, or any component of the formulation.
• Severe respiratory conditions: Conditions like respiratory depression or severe asthma, as codeine may worsen breathing difficulties.
• Liver or kidney impairment: Severe hepatic or renal dysfunction increases risk of toxicity from paracetamol and codeine.
• History of substance abuse: Patients with a history of opioid dependence or addiction should avoid this medication or use it under strict medical supervision.
• Children under 12 years: Due to the risk of serious adverse effects with codeine, use in this group is contraindicated unless specifically directed by a doctor.
• Use with MAO inhibitors: Concomitant use within 14 days is contraindicated due to risk of hypertensive crises.

Storage of ADOL COMPOUND

Proper storage of ADOL COMPOUND is essential to maintain its potency and safety:

• Store tablets in their original blister packaging until use to protect from moisture and light.
• Keep in a cool, dry place away from direct sunlight and heat sources.
• Maintain storage temperature below 25°C (77°F), unless otherwise specified by the manufacturer.
• Keep out of reach of children and pets to prevent accidental ingestion or overdose.
• Do not store in bathrooms or damp areas as humidity can degrade the medication.
• Check expiration date regularly and dispose of any expired or unused medicine safely according to local regulations.

Following these storage instructions helps ensure the medication remains effective and safe for use throughout its shelf life.