Active Substance: Oestrogens (conjugated).
Overview
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This medicine contains an important and useful components, as it consists of
Oestrogens (conjugated)is available in the market in concentration
Acyclovir
Renal impairment. Pregnancy, lactation. Neurological abnormalities with significant hypoxia, serious hepatic or electrolyte abnormalities. Maintain adequate hydration. Lactation: Drug enters breast milk; use with caution.
Herpes simplex infections,Varicella zoster (chickenpox),Herpes zoster (shingles),Genital herpes
Hypersensitivity.
>10% Oral Malaise (<12%) 1-10% Parenteral Inflammation or phlebitis at injection site (9%),Nausea (7%),Vomiting (7%),Rash or hives (2%),Elevated transaminase levels (1-2%) Oral Nausea (2-5%),Vomiting (<3%),Diarrhea (2-3%),Headache (2%) <1% Abdominal pain,Aggression/confusion,Agitation,Alopecia,Anaphylaxis,Anemia,Angioedema,Anorexia,Ataxia,Coma,Disseminated intravascular coagulation (DIC),Dizziness,Fatigue Potentially Fatal: Occasionally neurotoxicity after IV use: Lethargy, confusion, agitation, tremors, seizures, coma.
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Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.
Probenecid, cimetidine and mycophenolate mofetil may increase the plasma concentration of aciclovir. Increased nephrotoxic effects w/ drugs that affect renal physiology (e.g. ciclosporin, tacrolimus).
Information not available