Active Substance: Famciclovir.
Overview
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This medicine contains an important and useful components, as it consists of
Famcicloviris available in the market in concentration
Famciclovir INN
Renal impairment. Pregnancy. Lactation: Unknown whether drug is excreted in breast milk; caution advised
Genital herpes, Herpes zoster, Herpes labialis, CMV infections, Mucocutaneous herpes
Hypersensitivity. Lactation.
>10% Headache (23%),Nausea (13%) 1-10% Diarrhea (2-9%),Abdominal pain (8%),Dysmenorrhea (<8%),Vomiting (1-5%),Flatulence (5%),Pruritus (4%),Rash (3%),Paresthesia (3%),Neutropenia (3%),Increased transaminases (2-3%),Increased bilirubin (2%),Fatigue (1%) <1% Arthralgia,Confusion,Dizziness,Erythema multiforme,Hallucinations,Jaundice,Rigors,Thrombocytopenia,Upper respiratory tract infection
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Famciclovir rapidly undergoes biotransformation to penciclovir, which has inhibitory activity against HSV types 1 (HSV-1) and 2 (HSV-2) varicella-zoster virus (VZV). Thymidine kinase then phosphorylates penciclovir to a monophosphate form, which is then converted to penciclovir triphosphate. This inhibits HSV-2 DNA polymerase by competing with deoxyguanosine triphosphate, thus inhibiting herpes viral DNA synthesis and replication.
Reduced renal excretion resulting to increased plasma concentration w/ probenecid. Raloxifen may reduce the formation of penciclovir, the active metabolite of famciclovir.
Information not available