SIMVAGEN 10mg Price

Overview

Welcome to Dwaey, specifically on SIMVAGEN 10mg Tablets/Film-coated page.
This medicine contains an important and useful components, as it consists of Simvastatin.
SIMVAGEN 10mg is available in the market in concentration 10mg/Tablet and in the form of Tablets/Film-coated.

RIYADH PHARMA (MEDICAL AND COSMETIC PRODUCTS COMPANY LTD.) is the producer of SIMVAGEN 10mg and it is imported from SAUDI ARABIA, The most popular alternatives of SIMVAGEN 10mg are listed downward .

Mode Of Action

Simvastatin, an antilipemic agent is a competitive inhibitor of HMG-CoA reductase, the enzyme that catalyses the early and rate-limiting step in cholesterol biosynthesis reduces total cholesterol, LDL-cholesterol and triglycerides and increases HDL-cholesterol levels.

Indication

• Hyperlipidaemias
• stroke prevention

Precaution

History of liver disease. Increased risk of rhabdomyolysis in severe infection, hypotension, major surgical trauma, uncontrolled seizures or severe metabolic, endocrine and electrolyte disorder. Alcoholism; premenarcheal females; children <10 yr. Discontinue treatment if there is marked or persistent increase in serum-aminotransferase concentrations. Monitoring Parameters Monitor creatine kinase (CK) periodically and LFT. Discontinue if there is significant or persistent increase in CK levels, serum aminotransferase levels or evidence of myopathy. Lactation: Contraindicated; potentially unsafe

Side Effects

• 1-10% CPK elevation (>3x ULN) (5%)
• Constipation (2%)
• Upper respiratory infection (9%)
• Flatulence (1-2%)
• Transaminases increased (>3x ULN) (1%)
• Headache (3-7%)
• Myalgia (5%)
• Eczema (5%)
• Vertigo (5%)
• Abdominal pain (7%) <1% Myalgia
• Myopathy
• Arthralgia
• Arthritis
• Eosinophilia
• Chills
• Angioedema
• Rhabdomyolysis
• Abdominal pain Potentially Fatal: Severe rhabdomyolysis with acute renal failure.

Contra indication

Acute liver disease or unexplained persistent elevations of serum transaminases. Patients of Chinese descent should not take simvastatin 80 mg/day w/ lipid-modifying dose of niacin-containing products (?1 g). Simvastatin 80 mg should not be started in new patients and to those taking lower doses. Concurrent use w/ potent CYP3A4 inhibitors e.g. itraconazole, ketoconazole, posaconazole, clarithromycin, erythromycin, telithromycin, nefazodone, HIV protease inhibitors (e.g. nelfinavir), boceprivir, telaprevir., gemfibrozil, ciclosporin, danazol, grapefruit juice. Pregnancy and lactation.

Pregnancy and lactation

Pregnancy category: X

Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.