Active Substance: Pramoxine HCl, Hydrocortisone acetate.
Overview
Welcome to Dwaey, specifically on PROCTOFOAM HC page.
This medicine contains an important and useful components, as it consists of
Pramoxine HCl, Hydrocortisone acetateis available in the market in concentration
Hydrocortisone Acetate 2.5% + Pramoxine 1% Topical
Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary- adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients. Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings. Therefore, patients receiving a large dose of a potent topical steroid applied to a large surface area and under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent steroid. Recovery of HPA axis function is generally prompt and complete upon discontinuation of the drug. Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids. Children may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity. If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted. Lactation: excretion in milk unknown; use with caution In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.
Hemorrhoids, Insect bites, Skin irritations, Corticosteroid-responsive dermatoses, Anal itching
Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.
Burning,Itching,Irritation,Dryness,Folliculitis,Hypertrichosis,Acneiform eruptions,Hypopigmentation,Perioral dermatitis,Allergic contact dermatitis,Maceration of the skin,Secondary infection,Skin atrophy,Striae,Miliaria
3
Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It may also be used as replacement therapy in adrenocortical insufficiency. Local anesthetic; stabilizes neuronal membranes and prevent generation/conduction of nerve impulses by reducing sodium permeability and increasing action potential threshold.
Information not available
Information not available