Active Substance: Propantheline bromide.
Overview
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This medicine contains an important and useful components, as it consists of
Propantheline bromideis available in the market in concentration
Propantheline Bromide
Hyperthyroidism, congestive heart failure, coronary heart disease, cardiac arrhythmias, acute MI, cardiac insufficiency, hypertension. Pregnancy and lactation; elderly. Patients with fever, diarrhoea, GI reflux disease or ulcerative colitis. Hepatic or renal impairment. Increased risk of fever or heat stroke in patients exposed to high environmental temperature. Caution when used in patients with Down's syndrome.
Hyperhidrosis, Peptic ulcer, Urinary incontinence, GI tract spasm, Adult enuresis
Glaucoma, obstructive diseases of GI or urinary tract, severe ulcerative colitis or toxic megacolon, intestinal atony, hiatus hernia associated with reflux oesophagitis, unstable cardiovascular adjustment in acute bleeding, prostatic enlargement, myasthenia gravis, paralytic ileus, pyloric stenosis, angle-closure glaucoma.
>10% Constipation,Dry mouth,Dry skin,Decreased sweating Frequency Not Defined Blurred vision,Sedation,Tachycardia,Dysphagia,Urinary retention Potentially Fatal: Toxic megacolon due to preexisting ulcerative colitis.
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Propantheline bromide is a quarternary ammonium antimuscarinic with antisecretory and antispasmodic effects.
Additive anticholinergic effect with MAOIs, TCAs, phenothiazines, antihistamines and disopyramide. Delayed gastric emptying causes delayed absorption of other drugs. May antagonise the GI effects of domperidone, cisapride and metoclopramide. May reduce absorption of ketoconazole and levodopa. May increase absorption of nitrofurantoin. May increase serum levels of digoxin. May reduce effects of haloperidol and sublingual tablets of nitrates. May antagonise effects of parasympathomimetics.
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