DECUTAN 10mg Price

Overview

Welcome to Dwaey, specifically on DECUTAN 10mg page.
This medicine contains an important and useful components, as it consists of
Isotretinoinis available in the market in concentration

Name

Isotretinoin

Precaution

Before using **Isotretinoin**, it is crucial that patients consult their healthcare provider to ensure that the medication is appropriate for their condition. Key precautions include: - **Pregnancy and Teratogenicity**: **Isotretinoin** is known to cause **severe birth defects** and is strictly contraindicated during pregnancy. Women of childbearing age must undergo pregnancy testing before starting treatment, use two forms of contraception, and agree to regular pregnancy tests during treatment and for a month after discontinuation. - **Mental Health**: There have been reports of **depression**, **anxiety**, **mood swings**, and even **suicidal thoughts** associated with **Isotretinoin**. Patients should be closely monitored for any psychological symptoms, and treatment should be discontinued if significant mood disturbances occur. - **Liver Function**: **Isotretinoin** can impact **liver enzymes**, and liver function tests should be conducted before starting treatment and periodically throughout. The medication should be used with caution in patients with existing liver disease. - **Lipids and Cholesterol**: It can raise levels of **triglycerides** and **cholesterol**. Regular monitoring of blood lipids is recommended, and patients with elevated triglycerides should discontinue use due to the risk of **pancreatitis**. - **Sun Exposure and Skin Sensitivity**: Isotretinoin can make the skin more sensitive to the sun, increasing the risk of **sunburn**. Patients are advised to wear sunscreen and protective clothing when outdoors. - **Bone and Joint Health**: Long-term use of **Isotretinoin** has been associated with potential issues in **bone density** and **joint pain**, so caution is advised in patients with pre-existing musculoskeletal conditions.

Indication

**Isotretinoin** is primarily used to treat **severe acne** (also known as **nodulocystic acne**) that has not responded to other treatments such as oral antibiotics or topical medications. Its primary indications include: - **Severe Acne**: This includes **cystic acne**, which is characterized by large, inflamed pimples and cysts, often causing scarring. - **Acne Vulgaris**: **Isotretinoin** is often prescribed when acne has been persistent and resistant to other forms of treatment like **topical treatments** and **oral antibiotics**. - **Scarring Acne**: It is used to reduce the potential for **scarring** from severe forms of acne. - **Off-label Uses**: Occasionally, **Isotretinoin** is also used in the treatment of conditions like **rosacea** and **hidradenitis suppurativa**, although these uses are not FDA-approved.

Contra indication

**Isotretinoin** should not be used in the following cases: - **Pregnancy**: **Isotretinoin** is **teratogenic** and is contraindicated in **pregnant women** and women who are planning to become pregnant. It is highly effective at causing birth defects, including malformations of the **brain**, **heart**, **eyes**, and **face**. - **Hypersensitivity**: Patients with a history of **allergic reactions** to **Isotretinoin** or any of its ingredients should not use the medication. - **Liver Disorders**: **Isotretinoin** is metabolized by the liver, so it is contraindicated in patients with **severe liver disease** or elevated liver enzymes that are not correctable. - **Hyperlipidemia**: Due to the risk of **severe increases in triglyceride levels**, **Isotretinoin** should be avoided in patients with **severe hypertriglyceridemia** or a history of pancreatitis. - **Breastfeeding**: **Isotretinoin** should not be used by breastfeeding mothers, as the drug can be excreted in breast milk and may pose a risk to the infant.

Side Effect

Common side effects of **Isotretinoin** include: - **Dry Skin and Mucous Membranes**: The most frequent side effect is **dryness of the skin**, **lips**, **eyes**, and **mucous membranes**. This can cause **cracking lips**, **nosebleeds**, and **dry eyes**. - **Increased Sensitivity to Sun**: **Isotretinoin** can cause **photosensitivity**, leading to **severe sunburns** even with minimal sun exposure. - **Musculoskeletal Pain**: **Joint pain**, **muscle aches**, and **back pain** are common, particularly in high doses or long-term use. - **Mental Health Issues**: Some users report **depression**, **mood swings**, and **suicidal thoughts**. Patients should be monitored for any signs of mental health deterioration during treatment. - **Elevated Blood Lipids**: **Isotretinoin** may cause elevated levels of **cholesterol** and **triglycerides**, which can increase the risk of **pancreatitis**. - **Liver Enzyme Elevations**: Changes in **liver function tests** may occur, and the drug should be discontinued if liver enzymes become elevated. - **Hair Thinning**: Some patients may experience **temporary hair thinning**, although this is generally reversible after discontinuing the medication. - **Bleeding or Bruising**: Unexplained **bleeding** or **easy bruising** can occur due to the drug’s effects on the liver and blood vessels. Severe side effects, including **anaphylaxis**, **pancreatitis**, or **severe liver damage**, should prompt immediate cessation of the medication and emergency medical attention.

Pregnancy Category ID

5

Mode of Action

**Isotretinoin** works by targeting several key factors involved in the development of **acne**: - **Reduces Sebum Production**: **Isotretinoin** decreases the size and activity of **sebaceous glands**, reducing the production of **sebum** (skin oil), which is a major contributor to acne development. - **Prevents Pore Blockage**: It normalizes the **shedding of skin cells** in the hair follicles, preventing the formation of **comedones** (blackheads and whiteheads). - **Anti-Inflammatory Effects**: **Isotretinoin** has powerful **anti-inflammatory properties**, which help reduce the redness and swelling of acne lesions. - **Bacterial Action**: While not a primary mechanism, **Isotretinoin** also has mild **antibacterial** effects that help reduce the growth of **Propionibacterium acnes**, the bacteria associated with acne. The overall effect of **Isotretinoin** is the reduction of acne formation, improved skin texture, and reduced risk of scarring, making it one of the most effective treatments for severe acne.

Interaction

**Isotretinoin** may interact with several medications and substances, which could affect its efficacy or lead to adverse effects. Notable interactions include: - **Vitamin A**: Since **Isotretinoin** is a derivative of **vitamin A**, taking other vitamin A supplements or **retinoid medications** can increase the risk of **hypervitaminosis A** and associated toxicity, leading to symptoms like nausea, dizziness, and bone pain. - **Tetracyclines (e.g., Doxycycline, Minocycline)**: The combination of **Isotretinoin** and **tetracyclines** may increase the risk of **intracranial hypertension**, a condition characterized by high pressure within the skull, potentially leading to **headaches**, **blurred vision**, and even **permanent vision loss**. - **Steroids**: **Steroids** can increase the risk of developing **osteoporosis** when taken concurrently with **Isotretinoin**, especially when used for long durations. - **Alcohol**: **Isotretinoin** can strain liver function, and drinking **alcohol** may increase the risk of **liver damage** and exacerbate side effects related to the liver and lipid metabolism. - **Oral Contraceptives**: Although not typically a direct interaction, **Isotretinoin** may reduce the effectiveness of **oral contraceptives**, and backup contraception is advised while on treatment.

Pregnancy Category Note

Information not available

Adult Dose

The typical adult dose of **Isotretinoin** is based on body weight and the severity of acne: - **Initial Dose**: The usual starting dose is **0.5 mg/kg/day**, administered in **1 or 2 doses per day** with food. The dose may be increased based on response and tolerability. - **Typical Total Dose**: The cumulative dose is usually between **120 mg/kg and 150 mg/kg** over the course of the treatment. Most patients require about **16 to 24 weeks** of treatment. - **Maintenance**: After the initial treatment cycle, some patients may require **maintenance** therapy to prevent relapse, although many have long-term remission after a single course.

Child Dose

**Isotretinoin** is not typically prescribed for children under the age of 12 unless they have severe, treatment-resistant acne. For pediatric patients over 12: - **Dose**: The dosing is similar to that of adults, typically starting at **0.5 mg/kg/day**, with possible adjustments based on patient response and side effects. - **Monitoring**: Close monitoring of **side effects** and **blood tests** is required to ensure that the treatment does not lead to significant adverse effects, particularly on **lipid levels**, **liver function**, and **mental health**. As with adult patients, pediatric users must be informed of the **teratogenic risks** and the necessity for strict pregnancy prevention.

Renal Dose

**Isotretinoin** is primarily metabolized by the **liver** and is not significantly excreted by the kidneys. **Dose adjustments** for patients with **renal impairment** are not typically required. However, due to the potential for liver enzyme elevations, **monitoring of liver function** is crucial in all patients, especially those with pre-existing renal or liver issues.

Administration

Information not available