Active Substance: Cyproheptadine HCl.
Overview
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This medicine contains an important and useful components, as it consists of
Cyproheptadine HClis available in the market in concentration
Cyproheptadine HCI
Elderly; epilepsy; tasks requiring mental alertness; symptomatic prostate hypertrophy; epilepsy; alcoholism; pregnancy. Lactation: Excretion in milk unknown; contraindicated
Rash and pruritus in a variety of condition; appetite stimulation , anorexia nervosa ; cushing's and Nelson's syndrome, acromegaly and hyperprolactinemia ; migraine; antidepressant-induced inorgasmia .
Narrow-angle glaucoma; acute asthmatic attack; bladder neck obstruction; stenosing peptic ulcer; GIT obstruction; MAOIs therapy; hypersensitivity; neonates, lactation.
Psychiatric/neurologic: CNS depression, drowsiness, sedation ranging from mild drowsiness to deep sleep (most frequent), dizziness, lassitude, disturbed coordination; less commonly, restlessness, insomnia, tremors, euphoria, nervousness, irritability, delirium, seizures, toxic psychosis, paresthesia Muscular: Weakness Cardiovascular: Palpitation, tachycardia, palpitation, ECG changes (eg, widened QRS), arrhythmias (eg, extrasystole, heart block), hypotension, hypertension, dizziness, sedation, hypotension GI: Epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation Hepatic: Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice (rare) Skin: Eczema, pruritus, inflammation, papular rash, erythema on exposed skin Sensory: Visual disturbances, blurred vision, diplopia, tinnitus, acute labyrinthitis Renal: Dysuria, urinary retention Respiratory: Thickening of bronchial secretions, wheezing, nasal stuffiness Other: Vertigo, sweating, chills, early menses, headache, impotence, dryness of mouth, nose, and throat, facial dyskinesia, tightness of chest, faintness
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Cyproheptadine is a sedating antihistamine w/ antimuscarinic, serotonin antagonist and Ca channel blocking properties. It competes w/ histamine for H1-receptor sites on effector cells in the GI tract, blood vessels and resp tract.
May have additive effects w/ CNS depressants e.g. hypnotics, sedatives, tranquilizers, antianxiety agents. Potentially Fatal: MAOIs prolong and intensify the anticholinergic effects of antihistamines.
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