DECOZAL 0.05% Price

Overview

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This medicine contains an important and useful components, as it consists of
Xylometazoline HClis available in the market in concentration

Name

Xylometazoline Hydrochloride 0.05% Nasal prep

Precaution

Before using **Xylometazoline Hydrochloride 0.05% Nasal Prep**, it is essential to consult a healthcare provider to ensure that the medication is appropriate for the individual. The following precautions should be considered: - **Prolonged Use**: Xylometazoline should not be used for more than **3 consecutive days**. Prolonged use can lead to **rebound congestion**, where nasal congestion worsens once the medication is stopped. This is also known as **rhinitis medicamentosa**. - **Pre-existing Conditions**: Patients with **high blood pressure**, **heart disease**, **glaucoma**, or **thyroid problems** should use xylometazoline with caution, as the medication can lead to systemic absorption and exacerbate these conditions. - **Pregnancy**: Although xylometazoline is generally considered safe during pregnancy when used in recommended doses, it should still be used under a healthcare provider's supervision. It is classified as a **Category C** medication, which means its safety during pregnancy has not been fully established. - **Lactation**: Xylometazoline should be used cautiously during breastfeeding. It is not known if it passes into breast milk, so a healthcare provider should be consulted before using it while nursing. - **Children**: Xylometazoline nasal preparations are not recommended for **infants** or **young children** without a doctor's advice. It may cause unwanted side effects such as **central nervous system stimulation**.

Indication

Xylometazoline Hydrochloride 0.05% nasal spray is commonly used to provide **temporary relief** from nasal congestion. Its main indications include: - **Nasal Congestion**: Xylometazoline is primarily used to relieve nasal congestion caused by conditions such as the **common cold**, **allergic rhinitis**, **sinusitis**, and **hay fever**. It works by constricting the blood vessels in the nasal passages, reducing swelling and allowing easier breathing. - **Sinusitis**: It is used as a decongestant for **sinusitis**, helping to reduce sinus pressure and improve airflow. - **Pre-Surgical Use**: In some cases, xylometazoline may be used before **nasal surgery** or **diagnostic procedures** to reduce nasal congestion and ease access to the nasal passages.

Contra indication

Xylometazoline Hydrochloride 0.05% nasal spray should not be used in the following cases: - **Hypersensitivity to Xylometazoline**: If a patient has a known **allergy** or **hypersensitivity** to xylometazoline or any of the components of the nasal preparation, it should not be used. - **Narrow-Angle Glaucoma**: Patients with **narrow-angle glaucoma** should avoid using xylometazoline, as it may increase intraocular pressure. - **Severe Cardiovascular Disease**: Xylometazoline may cause an increase in **blood pressure** and **heart rate**, making it contraindicated in patients with **severe hypertension**, **tachycardia**, or other significant heart conditions. - **Rhinitis Medicamentosa**: If a patient has developed **rebound congestion** (rhinitis medicamentosa) due to prolonged use of decongestants, xylometazoline should be avoided. - **Children under 2 years**: The use of this nasal spray is not recommended in children under the age of 2 without proper medical advice due to the risk of adverse effects.

Side Effect

Common side effects associated with **Xylometazoline Hydrochloride 0.05% Nasal Prep** are usually mild and transient. However, some adverse effects to watch for include: - **Common Side Effects**: - **Nasal Irritation**: The most common side effect is **irritation** in the nose, including **burning**, **stinging**, or **dryness**. - **Sneezing**: Some individuals may experience **sneezing** after using the nasal spray. - **Rebound Congestion**: Prolonged use of the spray (more than 3 consecutive days) may lead to **rebound congestion** (rhinitis medicamentosa), worsening nasal congestion once the medication is stopped. - **Severe Side Effects**: - **Elevated Blood Pressure**: Xylometazoline can increase blood pressure, leading to **hypertension**. This is more likely in individuals with pre-existing heart conditions or those who misuse the product. - **Tachycardia**: **Increased heart rate** (tachycardia) may occur, especially in patients with cardiovascular issues. - **Central Nervous System Effects**: Some individuals may experience **restlessness**, **nervousness**, or **insomnia**, particularly with overuse or misuse. - **Severe Allergic Reactions**: Though rare, allergic reactions like **rash**, **swelling**, **dizziness**, or **difficulty breathing** may occur, requiring immediate medical attention.

Pregnancy Category ID

3

Mode of Action

Xylometazoline is a **sympathomimetic** drug that works by **stimulating alpha-adrenergic receptors** in the smooth muscle of the blood vessels in the nasal mucosa. By activating these receptors, xylometazoline causes **vasoconstriction**, or the narrowing of blood vessels, which leads to a reduction in **swelling and congestion** of the nasal passages. This results in improved airflow and relief from the feeling of a blocked nose. - **Vasoconstriction**: The primary mechanism of xylometazoline’s effect is through vasoconstriction, which reduces the blood flow to the nasal mucosa, alleviating swelling and congestion. - **Decreased Mucosal Edema**: This mechanism helps in reducing the thickness of the mucus lining the nasal passages, thereby providing relief from nasal obstruction due to conditions like **sinusitis**, **allergic rhinitis**, and the **common cold**.

Interaction

Xylometazoline Hydrochloride can interact with certain medications and substances, leading to potential adverse effects or reduced efficacy: - **Other Vasoconstrictors**: When used with other **sympathomimetic drugs** (e.g., **ephedrine**, **phenylephrine**, or certain **decongestant oral medications**), xylometazoline may increase the risk of **hypertension** and other cardiovascular problems due to the cumulative vasoconstrictor effect. - **Monoamine Oxidase Inhibitors (MAOIs)**: Using xylometazoline in combination with **MAO inhibitors** (such as **phenelzine** or **tranylcypromine**) can increase the risk of **hypertensive crisis**. These medications should be avoided concurrently. - **Antidepressants**: Concurrent use with **tricyclic antidepressants** (e.g., **amitriptyline**) or **selective serotonin-norepinephrine reuptake inhibitors** (SNRIs) may increase the risk of cardiovascular side effects such as **elevated heart rate** or **high blood pressure**. - **Other Antihypertensive Medications**: Xylometazoline may interfere with the action of **antihypertensive** drugs like **beta-blockers**, making it less effective in controlling blood pressure.

Pregnancy Category Note

Information not available

Adult Dose

The typical dosage for **Xylometazoline Hydrochloride 0.05% Nasal Prep** in adults is: - **1-2 sprays in each nostril** as needed, usually every **8 to 10 hours**. - The maximum recommended use is **3 days** to prevent rebound congestion or **rhinitis medicamentosa**. - It is important not to exceed the recommended dosage to avoid serious side effects like **elevated blood pressure** or **heart rate**.

Child Dose

For children, **Xylometazoline Hydrochloride 0.05% Nasal Prep** should be used with caution and typically only under the guidance of a healthcare provider: - **Children (2-12 years)**: The usual dose is **1 spray in each nostril** up to **2 times daily** (morning and evening). It is generally recommended to avoid prolonged use in children due to the risk of **rebound congestion**. - **Children under 2 years**: This medication is **not recommended** for children under 2 years of age without a doctor’s approval, as it may lead to severe side effects. --- As with any medication, **consult a healthcare provider** before initiating treatment with **Xylometazoline Hydrochloride 0.05% Nasal Prep**, especially if you have pre-existing conditions or are taking other medications. This ensures the medication is appropriate for your health needs and helps mitigate potential risks.

Renal Dose

There are no specific renal dose adjustments for **Xylometazoline Hydrochloride 0.05% Nasal Prep**. However, individuals with severe kidney impairment should use it with caution and under a healthcare provider’s supervision, as any systemic absorption can exacerbate existing health conditions.

Administration

Information not available