PANGESIC 250mg Price

Overview

Welcome to Dwaey, specifically on PANGESIC 250mg Capsules (Hard Gelatin) page.
This medicine contains an important and useful components, as it consists of Mefenamic acid.
PANGESIC 250mg is available in the market in concentration 250mg/Capsule and in the form of Capsules (Hard Gelatin).

RAM PHARMACEUTICAL INDUSTRIES CO. LTD. is the producer of PANGESIC 250mg and it is imported from JORDAN, The most popular alternatives of PANGESIC 250mg are listed downward .

Mode Of Action

Mefenamic acid, an anthranilic acid derivative, is a prototypical NSAID. It reversibly inhibits the cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors. It has analgesic and antipyretic properties w/ minor anti-inflammatory activity.

Indication

• Rheumatoid arthritis
• Osteoarthritis
• Dysmenorrhoea
• Menorrhagia
• Dental pain
• Pain and inflammation
• Mild to moderate pain
• Postoperative pain

Precaution

Patient w/ known CV disease or risk factors for CV disease, history of GI bleeding or peptic ulceration, fluid retention or heart failure. Renal and hepatic impairment. Anemia, bronchospasm, HTN, SLE, fluid retention, bleeding diathesis. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor CBC, chemistry profile, hepatic and renal function during long-term therapy. BP should be monitored closely during initiation and throughout therapy. Lactation: contraindicated; excreted in breast milk

Side Effects

• >10% Borderline elevations of one or more LFTs (<15%) 1-10% Abdominal pain
• Anorexia
• Diarrhea
• Nausea
• Pyrosis
• Gastritis
• Flatulence
• Constipation
• Steatorrhea
• Upper GI ulcers
• gross bleeding/perforation (1% of patients treated for 3-6 mth and 2-4% of those treated for 1 yo) <1% Leukopenia
• Eosinophilia
• Thrombocytopenic purpura
• Agranulocytosis
• Pancytopenia
• Bone marrow hypoplasia
• Renal failure (including papillary necrosis & acute interstitial nephritis)
• Acute interstitial nephritis has been associated with hematuria
• proteinuria
• & nephrotic syndrome Potentially Fatal: Autoimmune haemolytic anaemia; convulsions (overdosage).

Contra indication

Hypersensitivity to mefenamic acid, aspirin or other NSAIDs. Patient w/ inflammatory bowel disease, active ulceration or chronic inflammation of the upper or lower GI tract, renal failure. History of asthma, urticaria, allergic-type reactions. Treatment of perioperative pain in the setting of CABG surgery, pregnancy (3rd trimester), lactation. Coronary artery bypass graft surgery, severe renal impairment, severe heart failure.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Pregnancy Category: C; D in 3rd trimester or near delivery.