PANGESIC 250mg Capsules (Hard Gelatin)

What is PANGESIC 250mg

PANGESIC 250mg is a prescription nonsteroidal anti-inflammatory drug (NSAID) that contains the active ingredient mefenamic acid. It is formulated as hard gelatin capsules and each capsule contains 250mg of mefenamic acid. PANGESIC is primarily used for the relief of mild to moderate pain, including menstrual pain (dysmenorrhea), musculoskeletal pain, dental pain, and headaches.

• Generic Name: Mefenamic acid
• Form: Hard gelatin capsules
• Strength: 250mg
• Pack Size: 100s (10s Blister x 10)
• Therapeutic Class: NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)

Mefenamic acid works by reducing hormones that cause inflammation and pain in the body. It is often prescribed when other milder painkillers are not effective enough.

How to use PANGESIC 250mg

PANGESIC 250mg should be used exactly as directed by your healthcare provider. It is important to take this medicine with food or milk to reduce the risk of gastrointestinal upset. Do not increase the dose or frequency without medical advice.

• Route: Oral
• Administration: Swallow the capsule whole with a full glass of water.
• Timing: Take at the onset of pain and continue as needed, usually every 6 hours.
• With Food: Recommended to be taken with meals to minimize gastrointestinal discomfort.
• Missed Dose: Take the missed dose as soon as you remember unless it is nearly time for the next one.

Do not use PANGESIC for more than 7 days continuously without consulting your doctor. Long-term use can increase the risk of serious gastrointestinal or cardiovascular effects.

Mode of Action PANGESIC 250mg

Mefenamic acid, the active compound in PANGESIC 250mg, is a NSAID that acts by inhibiting the enzyme cyclooxygenase (COX). This enzyme is responsible for the synthesis of prostaglandins, which mediate inflammation, pain, and fever.

• COX Inhibition: It blocks both COX-1 and COX-2 enzymes, leading to decreased production of prostaglandins.
• Analgesic Effect: Reduces sensitivity of pain receptors, providing pain relief.
• Anti-inflammatory Effect: Decreases swelling, redness, and inflammation at the site of pain or injury.
• Antipyretic Effect: Helps reduce fever by acting on the hypothalamus to lower body temperature.

This triple action makes PANGESIC effective in managing various types of pain, particularly those associated with inflammation.

PANGESIC 250mg Interactions PANGESIC 250mg

PANGESIC may interact with other medications, potentially altering their effects or increasing the risk of adverse reactions. Always inform your doctor or pharmacist of all medications you are taking, including prescription, over-the-counter, and herbal supplements.

• Anticoagulants (e.g., warfarin): Increased risk of bleeding.
• Antihypertensives (e.g., ACE inhibitors, beta-blockers): May reduce effectiveness of blood pressure control.
• Diuretics: May decrease diuretic response and increase nephrotoxicity risk.
• Other NSAIDs or Aspirin: Increased risk of gastrointestinal side effects and kidney damage.
• SSRIs (e.g., fluoxetine): Enhanced risk of bleeding due to platelet inhibition.
• Cyclosporine: Increased risk of nephrotoxicity.
• Lithium: NSAIDs may increase lithium levels and toxicity risk.

Monitoring is advised when PANGESIC is used concurrently with any of the above agents. Do not start or stop medications without consulting your healthcare provider.

Dosage of PANGESIC 250mg

The dosage of PANGESIC 250mg depends on the patient’s age, weight, medical condition, and response to treatment. It should be used at the lowest effective dose for the shortest duration necessary.

• Adults and Adolescents over 14 years: 500mg initially, followed by 250mg every 6 hours as needed. Maximum duration should not exceed 7 days.
• Dysmenorrhea: 500mg as an initial dose, then 250mg every 6 hours during the period of pain.
• Maximum Daily Dose: Should not exceed 1500mg per day.
• Children: Not recommended for children under 14 years of age.

Prolonged use should be avoided due to increased risks of gastrointestinal, renal, and cardiovascular adverse effects. Always consult a healthcare professional before modifying the dosage.

Possible side effects of PANGESIC 250mg

Like all medications, PANGESIC 250mg may cause side effects. Most are mild and temporary, but serious reactions can occur. If any of the following occur, medical attention should be sought immediately.

• Common Side Effects:
  • Abdominal pain
  • Diarrhea or constipation
  • Heartburn or indigestion
  • Dizziness or drowsiness
  • Headache
• Serious Side Effects:
  • Gastrointestinal bleeding or ulcers
  • Severe allergic reactions (rash, itching, swelling)
  • Kidney or liver dysfunction
  • Hypertension
  • Shortness of breath or chest pain

Stop using the medication and contact your doctor if you experience black or bloody stools, persistent stomach pain, yellowing of the skin or eyes, or difficulty breathing.

PANGESIC 250mg Contraindications PANGESIC 250mg

PANGESIC 250mg should not be used in certain individuals due to potential risks. Inform your doctor if any of the following apply to you:

• Hypersensitivity: Allergy to mefenamic acid, aspirin, or other NSAIDs.
• Peptic Ulcer Disease: Active or history of gastrointestinal ulcers or bleeding.
• Kidney or Liver Impairment: Severe renal or hepatic dysfunction increases the risk of toxicity.
• Heart Failure or Hypertension: May worsen fluid retention and blood pressure control.
• Asthma: NSAIDs may trigger bronchospasm in sensitive individuals.
• Pregnancy (especially third trimester): Avoid due to risk of fetal complications.
• Breastfeeding: Caution is advised as small amounts may be excreted in breast milk.

Always consult a healthcare provider before starting this medication, especially if you have chronic conditions or are on long-term treatments.

Storage of PANGESIC 250mg

Proper storage of PANGESIC 250mg ensures the medication retains its effectiveness and safety until the expiry date.

• Temperature: Store below 25°C (77°F). Do not freeze.
• Humidity: Keep in a dry place, away from moisture.
• Light: Protect from direct sunlight and excessive heat.
• Container: Store in the original blister pack until ready to use.
• Keep out of reach: Ensure children do not have access to the medicine.
• Disposal: Do not flush unused medication down the toilet. Dispose of through proper pharmaceutical waste channels.

Check the expiry date regularly and do not use PANGESIC after it has expired. Consult your pharmacist on how to safely discard expired or unused medications.