OXACIN 0.3% Price

Overview

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This medicine contains an important and useful components, as it consists of
Ofloxacinis available in the market in concentration

Name

Ofloxacin

Precaution

Epilepsy or other predisposition to seizures; known or suspected CNS disorders; renal, hepatic impairment; myasthaenia gravis; superinfection; children <18 yr; exposure to strong sunlight and UV light; ensure adequate hydration; elderly. Lactation: excreted in breast milk, discontinue drug or do not nurse

Indication

Leprosy,chronic bronchitis; Community-acquired pneumonia; Uncomplicated skin infections,anthrax,Legionnaire's disease,Nongonococcal cervicitis; Urethritis, Uncomplicated cystitis, Complicated UTI, Traveller's diarrhea, bacterial prostatis, Typhoid fever, Skin and soft tissue infections, Uncomplicated gonorrhea, Pelvic inflammatory disease, Lower respiratory tract infections, Septicaemia

Contra indication

Hypersensitivity to quinolones; pregnancy and lactation; prolongation of the QT interval; uncorrected hypokalaemia.

Side Effect

1-10% Nausea (3-10%),Headache (1-9%),Insomnia (3-7%),Dizziness (1-5%),Vaginitis (1-5%),Diarrhea (1-4%),Vomiting (1-4%),Appetite decreased (1-3%),Abdominal cramps (1-3%),Abnormal taste (1-3%),Chest pain (1-3%),External genital pruritis in women (1-3%),Fatigue (1-3%),Flatulence (1-3%),GI distress (1-3%),Nervousness (1-3%),Pharyngitis (1-3%),Pyrexia (1-3%),Rash/pruritis (1-3%),Sleep disorders (1-3%),Visual disturbances (1-3%),Xerostomia (1-3%) <1% Prolonged QT interval,Torsades de pointes,Syncope,Vasculitis,Edema,HTN,Palpitations,Vasodilation,Stevens-Johnson syndrome,Toxic epidermal necrolysis,Agranulocytosis,Aplastic anemia,Pancytopenia,Thrombocytopenia,Thrombocytopenic purpura,Acute hepatitis,Hepatic failure,Hepatic necrosiImmune hypersensitivity reaction,Rupture of tendon, Tendinitis,Peripheral neuropathy,Seizure,Acute renal failure,Interstitial nephritis,Renal impairment,Tourette's syndrome,Decrease hearing acuity,Tinnitus Potentially Fatal: Anaphylaxis; rarely seizures.

Pregnancy Category ID

3

Mode of Action

Ofloxacin is a fluoroquinolone which inhibits bacterial topoisomerase IV and DNA gyrase enzymes required for DNA replication, transcription, repair and recombination. It has activity against a wide range of gram-negative and gram-positive microorganisms.

Interaction

Concomitant use of class IA (e.g. quinidine, procainamide) or class III (e.g. amiodarone, sotalol) antiarrhythmic agents may increase risk of QT interval prolongation. Decreased serum and urine concentrations w/ antacids containing Mg, Al or Ca. Additive antibacterial activity w/ aminoglycosides (e.g. amikacin, tobramycin). Corticosteroids may increase risk of severe tendon disorders. Increased risk of CNS stimulation (e.g. seizures) w/ NSAIDs. Higher and prolonged serum theophylline concentrations and increased risk of theophylline-related adverse effects.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration