NITROCINE 1mg/ml Price

Overview

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This medicine contains an important and useful components, as it consists of
Glyceryl trinitrateis available in the market in concentration

Name

Glyceryl Trinitrate (nitroglycerine)

Precaution

Severe hepatic or renal impairment, hypothyroidism, malnutrition, hypothermia. Cerebrovascular disease, lung disease or cor pulmonale. Pregnancy, lactation, glaucoma, mitral valve prolapse, cardiac tamponade, syncope. Gradual withdrawal in patients who have received prolonged high dose infusions. Avoid prolonged excessive hypotension. Nitrate-free interval is recommended in patients on continuous treatment with nitrates to reduce risk of tolerance. Lactation: not known whether the drug crosses into breast milk, use caution

Indication

Angina pectoris, Acute myocardial infarction, Severe hypertension, Pulmonary edema.

Contra indication

Hypersensitivity. Severe hypotension, heart failure, marked anaemia, hypertrophic obstructive cardiomyopathy, cerebral haemorrhage or head trauma, low cardiac output secondary to hypovolaemia, inferior MI with right ventricular involvement, raised intracranial pressure. Concomitant use with phosphodiesterase type-5 inhibitors.

Side Effect

Common Headache,Hypotension,Tachycardia,Dizziness,Lightheadedness,Blurred vision,Flushing,N/V,Nervousness,Xerostomia Serious Methemoglobinemia (rare),Syncope,Prolonged bleeding time,Exfoliative dermatitis,Unstable angina,Rebound hypertension,Thrombocytopenia Sublingual Tabs/Spray: Dry mouth, localised burning sensation. Buccal tablets: Delayed dissolution, may be swallowed by mistake. Potentially Fatal: Hypotension, paradoxical bradycardia, impaired respiration, syncope and collapse.

Pregnancy Category ID

3

Mode of Action

Glyceryl trinitrate acts on the enzyme nitric oxide stimulating guanylate cyclase in the vascular smooth muscle cells resulting in the relaxation of smooth muscles. It reduces venous return (preload) and facilitates subendocardial blood flow with redistribution into ischaemic areas. It relieves coronary vasospasm and dilates arterioles reducing afterload. It is useful for relief and prevention of anginal attacks.

Interaction

Enhances bioavailability of dihydroergotamine. Glyceryl trinitrate infusion may prolong pancuronium-induced neuromuscular blockade. May reduce the efficacy of heparin, alteplase and noradrenaline when used together. Efficacy of buccal and sublingual preparations may be reduced by drugs that can cause dry mouth due to decreased dissolution. Aspirin and other NSAIDs may reduce the therapeutic response to glyceryl trinitrate. Potentially Fatal: Orthostatic hypotension may be produced by combined use of calcium channel blockers, antihypertensives, phenothiazines and TCAs. Alcohol may cause severe hypotension and collapse.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration