AERINAZE 2.5mg/120mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Desloratadine, Pseudoephedrine (as sulfate)is available in the market in concentration

Name

Desloratadine + Pseudoephedrine Sulphate

Precaution

Severe renal or hepatic failure; children <6 mth, elderly, epilepsy, pregnancy and lactation. Lactation: both drugs pass into breast milk, pseudoephedrine is concentrated in breast milk; use caution

Indication

Allergic rhinitis, Itching, Sneezing, Watery eyes, Runny nose, Hives, Skin rash, Common cold, Nasal congestion

Contra indication

Hypersensitivity.

Side Effect

>10% Desloratadine Fever (12%),Irritability (12%),Headache (12%),Diarrhea (15-21%),Cough (11%),Upper respiratory tract infection (11-21%) 1-10% Desloratadine Pharyngitis (4.1%),Dry mouth (3%),Myalgia (2.1%),Emotional lability (3%),Erythema (3%),Macopapular rash (3%),Dizziness (4%),Fatigue (2.1%),Somnolence (2.1%)Urinary tract infection (4%),Dyspepsia (3%),Insomnia (5%),Dysmenorrhea (2.1%) Frequency Not Defined Pseudoephedrine CNS (tremor, restlessness, etc),Insomnia,Arrhythmia,Hypotension,Tachycardia,Fatigue,Rash,Urticaria,Anorexia,Xerostomia,Dysuria,Polyuria,Nausea,Vomiting,Ischemic colitis

Pregnancy Category ID

3

Mode of Action

Desloratadine is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils. Pseudoephedrine is both an ?-and ?-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of ?-adrenergic receptors of the respiratory mucosa. It also directly stimulates ?-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.

Interaction

Potential increase in plasma concentrations w/ drugs affecting hepatic microsomal enzymes (e.g. azithromycin, cimetidine, erythromycin, fluoxetine, ketoconazole). Increased risk of hypertension and arrhythmias if given with cardiac glycosides, quinidine or TCAs. Increased risk of vasoconstrictor effects if given with ergot alkaloids or oxytocin. Co-admin with MAOIs may cause hypertensive crisis. Anaesthetics e.g. cyclopropane, halothane and other halogenated anaesthestics; antihypertensive agents.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration