METOPRESS XL 50mg Price

Overview

Welcome to Dwaey, specifically on METOPRESS XL 50mg page.
This medicine contains an important and useful components, as it consists of
Metoprololis available in the market in concentration

Name

Metoprolol Tartrate

Precaution

Patients w/ myasthenia gravis, well-compensated heart failure, bronchospastic disease, AV conduction disorders, substantial cardiomegaly. May mask signs and symptoms of hyperthyroidism and hypoglycaemia. Patients w/ history of cardiac failure or those w/ minimal cardiac reserve. Patients undergoing major surgery involving general anaesth. Avoid abrupt withdrawal as it may precipitate thyroid storm or MI, and may exacerbate angina and ventricular arrhythmias. Hepatic impairment. Pregnancy and lactation. Patient Counselling May affect ability to drive or operate machinery. Monitoring Parameters Monitor BP, ECG and heart rate. Lactation: Drug is concentrated in breast milk; use with caution (American Academy of Pediatrics states that drug is compatible with nursing)

Indication

Heart failure, Migraine, Acute MI, Diabetic nephropathy, Hypertension, Cardiac arrhythmias, Angina pectoris

Contra indication

2nd or 3rd degree AV block, sick sinus syndrome, hypotension, decompensated heart failure, sinus bradycardia, severe peripheral arterial circulatory disorders, cardiogenic shock, severe asthma and bronchospasm, untreated phaeochromocytoma, Prinzmetal's angina, metabolic acidosis.

Side Effect

1-10% Dizziness (10%),Headache (10%),Tiredness (10%),Depression (5%),Diarrhea (5%),.Pruritus (5%),Bradycardia (9%),Rash (5%),Dyspnea (1-3%),Cold extremities (1%),Constipation (1%),Dyspepsia (1%),Heart failure (1%),Hypotension (1%),Nausea (1%),Flatulence (1%),Heartburn (1%),Xerostomia (1%),Wheezing (1%),Bronchospasm (1%) Frequency Not Defined Decreased exercise tolerance,Raynaud phenomenon,Increased triglyceride levels and insulin resistance, decreased high-density lipoprotein (HDL) levels

Pregnancy Category ID

3

Mode of Action

Metoprolol selectively inhibits beta1-adrenergic receptors but has little or no effect on beta2-receptors except in high doses. It does not exhibit membrane stabilising or intrinsic sympathomimetic activity.

Interaction

Additive effect w/ catecholamine-depleting drugs (e.g. reserpine) and MAOIs. May antagonise ?1-adrenergic stimulating effects of sympathomimetics. Additive negative effects on SA or AV nodal conduction w/ cardiac glycosides, nondihydropyridine Ca channel blockers. Paradoxical response to epinephrine may occur. Increased plasma concentrations w/ CYP2D6 inhibitors (e.g. bupropion, cimetidine). Increased risk of hypotension and heart failure w/ myocardial depressant general anaesth (e.g. diethyl ether). Risk of pulmonary HTN w/ vasodilators (e.g. hydralazine) in uraemic patients. Reduced plasma levels w/ rifampicin. May increase negative inotropic and negative dromotropic effect of antiarrhythmic drugs (e.g. quinidine, amiodarone). May reduce antihypertensive efficacy w/ indometacin. May increase effects of hypoglycaemics.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration