METHOTREXATE 500mg/20ml price in UAE

Overview

Welcome to Dwaey, specifically on METHOTREXATE 500mg/20ml Infusion page.
This medicine contains an important and useful components, as it consists of Methotrexate.
METHOTREXATE 500mg/20ml is available in the market in concentration 25mg/ml and in the form of Infusion.

LEDERLE PHARMACEUTICALS (CYANAMIDE GmbH) is the producer of METHOTREXATE 500mg/20ml and it is imported from GERMANY, The most popular alternatives of METHOTREXATE 500mg/20ml are listed downward .

Mode Of Action

Methotrexate is a folic acid antagonist that inhibits DNA synthesis. It irreversibly binds to dihydrofolate reductase, inhibiting the formation of reduced folates, and thymidylate synthetase, resulting in inhibition of purine and thymidylic acid synthesis.

Indication

Burkitt's lymphoma
Choriocarcinoma
Mycosis fungoides
Crohn's disease
Psoriasis
Osteosarcoma
Breast cancer
lymphosarcoma
Acute lymphoblastic leukaemia
Rheumatoid arthritis

Precaution

Hepatic or renal impairment, bone marrow depression, elderly, neonates. Ulcerative disorders of the GI tract. Monitor haematological, renal and hepatic function, and GI toxicity regularly. Lactation: Drug excreted in breast milk; do not nurse

Side Effects

>10% Arachnoiditis with intrathecal administration
Subacute toxicity with intrathecal administration (paralysis of extremities
cranial nerve palsy
seizure or coma)
Demyelinating encephalopathy with cranial irradiation or other systemic chemotherapy
Reddening of skin
Hyperuricemia
Ulcerative stomatitis
Glossitis
Gingivitis
Nausea and vomiting
Diarrhea
Anorexia
Intestinal perforation
Mucositis (dose-dependent)
Leukopenia
Thrombocytopenia
Renal failure
Azotemia
Nephropathy
Pharyngitis 1-10% Alopecia
Photosensitivity
Rash
Abdominal distress
Malaise
Fatigue
Chills
fever
Decreased resistance to infection
Gastrointestinal hemorrhage
Myelosuppression
Disorders of lung
interstitial pneumonia (acute
chronic)
Atrophy of liver
cirrhosis
hepatic fibrosis or necrosis
elevated liver function tests
hepatic failure Potentially Fatal: Pulmonary reactions (e.g. interstitial lung disease); neurotoxicity (e.g. leukoencephalopathy
paresis
demyelination) with intrathecal use; foetal deaths.

Contra indication

Severe renal or hepatic impairment, pre-existing profound bone marrow suppression in patients with psoriasis or rheumatoid arthritis, alcoholic liver disease, AIDS, pre-existing blood dyscrasias, pregnancy (in patients with psoriasis or rheumatoid arthritis), breast-feeding.

Pregnancy and lactation

Pregnancy category: X

Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Interaction

Decreased effectiveness with folic acid and its derivatives. Potentially Fatal: Increased toxicity with NSAIDs and salicylates; probenecid; some penicillins; aminoglycosides neomycin and paromomycin; sulfonamides such as sulfafurazole and sulfamethoxazole; co-trimoxazole or trimethoprim; nephrotoxic agents (e.g. cisplatin); ciclosporin; etretinate. Synergistic enhancement of effects with fluorouracil. Increased bioavailability of mercaptopurine. Reduces serum-valproate concentrations. Reduced serum concentrations with colestyramine. Increased serum concentrations with omeprazole.