INDOGESIC 25mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Indomethacinis available in the market in concentration

Name

Indomethacin

Precaution

Patient w/ known CV disease or risk factors for CV disease, fluid retention, history of GI disease (e.g. bleeding or ulcers), history of mental depression or other psychiatric disorder, epilepsy, or parkinsonian syndrome; existing infection that is adequately controlled. May mask signs and symptoms of infection. Hepatic and renal impairment. Elderly, childn. Pregnancy and lactation. Lactation: Drug enters breast milk; use not recommended (American Academy of Pediatrics committee states that drug is compatible with nursing)

Indication

Rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis (degenerative joint disease), gout, acute non-articular rheumatism (bursitis, synovitis, tendinitis).

Contra indication

Indomethacin is contraindicated in patients with ulcer, gastritis, active ulcerative colitis, and should be used with caution in patients with a history of these disorders. It is also contraindicated in previously hypersensitive patient.

Side Effect

>10% Transient renal insufficiency (40%),Jaundice (<15%),Elevated liver function test values (?15%),Headache (12%) 1-10% Dizziness (3-9%),Dyspepsia (3-9%),Epigastric pain (3-9%),Indigestion (3-9%),Nausea (3-9%) Symptomatic upper GI ulcers, gross bleeding/perforation (4% of patients treated for 1 year; 1% of patients treated for 3-6 months). Abnormal pain/cramps/distress (<3%),Constipation (1-3%),Depression (1-3%),Diarrhea (1-3%),Fatigue (1-3%),Somnolence (1-3%),Tinnitus (1-3%),Vertigo (1-3%) <1% Acute interstitial nephritis with hematuria/proteinuria,Acute respiratory distress,Agranulocytosis,Angioedema,Aplastic anemia,Asthma,Bone marrow depression,Congestive heart failure (CHF),Hemolytic anemia,Leukopenia,Macular and morbilliform eruptions,Pulmonary edema,Thrombocytopenia,Thrombocytopenic purpura,Ulcerative stomatitis,Urticaria

Pregnancy Category ID

3

Mode of Action

Indometacin, an indole acetic acid derivative has anti-inflammatory, analgesic and antipyretic actions. It reversibly inhibits cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors.

Interaction

May increase plasma levels of methotrexate. Increased risk of GI bleeding w/ warfarin. May reduce hypotensive effects of hydralazine, furosemide, ?-blockers (e.g. atenolol, propranolol, oxprenolol), or thiazide diuretics. Increased risk of hyperkalaemia w/ K-sparing diuretics, ACE inhibitors, K supplements. May increase nephrotoxic effects of ciclosporin or triamterene. Increase plasma concentration w/ probenecid. May increase plasma levels of aminoglycoside (e.g. amikacin, gentamicin) in premature neonates. May enhance antipsychotic effect (e.g. severe drowsiness and confusion) of haloperidol. Al- or Mg-containing antacids may reduce GI disorders of indometacin. Potentially Fatal: Diflunisal decreases renal clearance and increases plasma concentrations of indometacin which leads to fatal GI haemorrhage.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration