IMIPENEM - CILASTATIN LABATEC 500mg

Overview

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This medicine contains an important and useful components, as it consists of
Cilastatin (as sodium), Imipenem (as monohydrate)is available in the market in concentration

Name

Imipenem + Cilastatin

Precaution

Caution when used in patients with known hypersensitivity to other beta-lactams due to possibility of cross-sensitivity. CNS disorders such as epilepsy; renal, hepatic impairment; pregnancy, lactation. Lactation: Drug distributed in breast milk; use with caution

Indication

Cystic fibrosis, Bacterial septicemia, Endocarditis, Susceptible infections, Lower Respiratory Tract Infections, Gonorrhea, Skin and skin structure infections, Urinary tract infections, Bone and Joint Infections, Surgical Prophylaxis

Contra indication

Hypersensitivity.

Side Effect

1-10% Phlebitis (2-5%),Eosinophilia (4%),Miscellaneous dermatologic effects (<3%),Potentially false-positive Coombs test (2%),Miscellaneous hematologic effects (<2%),Transient increase in blood urea nitrogen (BUN) or serum creatinine (<2%),Seizures (1.5%),Nausea, diarrhea, vomiting (1-2%) <1% Abnormal urinalysis,Agitation,Anaphylaxis,Anemia,Confusion (acute),Dizziness,Dyskinesia,Emergence of resistant strains of Pseudomonas aeruginosa,Fever,Hypersensitivity,Hypotension,Elevated liver function test (LFT) results,Increased prothrombin time (PT),Neutropenia (including agranulocytosis),Palpitations,Pruritus,Pseudomembranous colitis Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis.

Pregnancy Category ID

3

Mode of Action

Imipenem is a potent inhibitor of bacterial cell wall synthesis and is bactericidal against a broad spectrum of pathogens. It is resistant to degradation by bacterial beta-lactamases. Cilastatin is an inhibitor of dehydropeptidase I, an enzyme found in the brush border of the renal tubules. It is given as the sodium salt with imipenem to prevent its renal metabolism and protect against nephrotoxic effects.

Interaction

Concurrent admin with probenecid may increase the half-life of cilastatin. Increased risk of generalised seizures when used concurrently with ganciclovir.