Active Substance: Pentosan polysulphate.
Overview
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This medicine contains an important and useful components, as it consists of
Pentosan polysulphateis available in the market in concentration
Pentosan Polysulphate Sodium
Patients with spleen disorders, hepatic or renal impairment. Monitor platelet counts during treatment. To discontinue treatment if thrombocytopenia occurs. Caution when used in patients with haemorrhagic blood disorders, thrombocytopenia, peptic ulcer disease, cerebrovascular disorders, bacterial endocarditis, severe hypertension or oesophageal varices. Recent surgery at sites where haemorrhage would be an especial risk. Safety not established in children <16 yr. Patients should be monitored every 3 mth; risks and benefits after 6 mth of treatment not known. Pregnancy; lactation. Lactation: not known if excreted in breast milk, use caution
Interstitial cystitis, Nocturia, Painful bladder syndrome, Dyspareunia
Patients who are haemorrhaging. Serious renal or hepatic impairment. Not to be given via IM inj.
1-10% Alopecia (4%),Diarrhea (4%),Nausea (4%),Headache (3%),Abdominal pain (2%),Indigestion (2%)
2
Pentosan polysulfate sodium is a heparinoid with anticoagulant and fibrinolytic properties; it may also have hypolipidaemic and anti-inflammatory effects. It is used in thromboembolic disorders, although its anticoagulant effect is less than that of heparin. It is also used in the management of interstitial cystitis and has been tried in a number of other conditions, including variant Creutzfeldt-Jakob disease.
Increased risk of bleeding when used with oral anticoagulants or drugs that affect platelet function. Concurrent admin with glyceryl trinitrate via IV route may reduce the efficacy of pentosan.
Information not available