GENTACIN 0.3% Price

Overview

Welcome to Dwaey, specifically on GENTACIN 0.3% page.
This medicine contains an important and useful components, as it consists of
Gentamicin (as sulfate)is available in the market in concentration

Name

Gentamicin

Precaution

History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment, perforated ear drum. Lactation: Enters breast milk; use with caution (AAP Committee states "compatible with nursing")

Indication

Pneumonia, Cystic fibrosis, Meningitis, Peritonitis, Endocarditis, Susceptible infections, Septicaemia, Pelvic inflammatory disease, Endometritis, Biliary tract infections, Granuloma inguinale, Listeriosis, Gastroenteritis, Plague, Cat scratch disease, Brucellosis, Otitis externa, Surgical infections, Skin infections.

Contra indication

History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment, perforated ear drum.

Side Effect

>10% Neurotoxicity (vertigo, ataxia),Gait instability,Ototoxicity (auditory, vestibular),Nephrotoxicity (decreased CrCl),Nephrotoxicity if trough >2 mg/L 1-10% Edema,Rash,Reddening of skin,Itching <1% Drowsiness,Headache,Pseudomotor cerebri,Photosensitivity,Allergic reaction,Erythema,Anorexia,Nausea/vomiting,Weight loss,Increased salivation,Enterocolitis,Granulocytopenia,Agranulocytosis,Thrombocytopenia,Elevated LFT Burning,Stinging,Tremors,Muscle cramps,Weakness,Dyspnea Potentially Fatal: Nephrotoxicity, ototoxicity and neuromuscular blockade (may unmask or aggravate myasthaenia gravis).

Pregnancy Category ID

4

Mode of Action

Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.

Interaction

Synergistic with ampicillin, benzylpenicillin and other beta-lactam antibiotics. Increased risk of severe respiratory depression when used concurrently with anaesthetics or opioids. May reduce renal clearance of zalcitabine and induce hypocalcaemia when used with biphosphonates. Not to be used with agalsidase alfa or beta as it may inhibit alpha-galactosidase activity. Potentially Fatal: Increased incidence of ototoxicity when combined with ethacrynic acid and furosemide. Cephalosporins, ciclosporin, cisplatin, vancomycin, hydrocortisone and indometacin potentiate nephrotoxicity. Potentiates neuromuscular blocking agents.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration