DALACIN-C 150mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Clindamycin (as HCl)is available in the market in concentration

Name

Alfuzosin

Precaution

- Alfuzosin should be used cautiously in patients with a history of hypotension (low blood pressure) or those who are at risk of developing hypotension. - It is recommended to monitor patients for signs of orthostatic hypotension, as the drug can cause dizziness or fainting, especially when standing up quickly. - Patients with a history of prostate cancer should be evaluated for potential malignancy before starting alfuzosin therapy, as it may interfere with the detection of prostate cancer. - Alfuzosin should be used with caution in patients with severe hepatic impairment. Dosage adjustments may be necessary in this population. - Those with a history of arrhythmias or other cardiovascular issues should be monitored closely during treatment, as alfuzosin can impact heart rhythm. - It should be used with caution in elderly individuals, as they may be more susceptible to its blood pressure-lowering effects and other side effects. - Since alfuzosin can cause dizziness, patients should be advised not to engage in tasks requiring mental alertness, such as driving or operating heavy machinery, especially when initiating therapy or after a dose increase. - Alfuzosin is not recommended in combination with other alpha-blockers due to an increased risk of hypotension.

Indication

- Alfuzosin is primarily indicated for the treatment of benign prostatic hyperplasia (BPH) in men. It helps relieve symptoms such as difficulty urinating, weak stream, and frequent urination. - It can also be used as an adjunct therapy in the management of lower urinary tract symptoms (LUTS) associated with BPH. - Alfuzosin may be prescribed off-label in certain cases for managing hypertension (high blood pressure), although this is not its primary approved indication. - In some cases, it may be used to facilitate urinary flow during the management of kidney stones or bladder outlet obstruction. - Alfuzosin can also be used in conjunction with other treatments for BPH to reduce the need for surgical intervention.

Contra indication

- Alfuzosin is contraindicated in patients with a known hypersensitivity or allergy to the drug or any of its components. - It should not be used in individuals with a history of orthostatic hypotension or those who are prone to experiencing significant drops in blood pressure. - Alfuzosin is contraindicated in patients with severe hepatic impairment (Child-Pugh class C) due to potential severe adverse reactions. - Patients with a history of prostate cancer or those who are at high risk for developing prostate cancer should avoid the use of alfuzosin unless a thorough evaluation indicates otherwise. - The drug is contraindicated in patients taking potent cytochrome P450 3A4 inhibitors, as this can increase alfuzosin blood concentrations, leading to dangerous side effects such as severe hypotension. - It is not recommended for use in combination with other alpha-adrenergic blockers or medications that may further lower blood pressure, such as nitrates or antihypertensive agents. - Alfuzosin should not be used in individuals with severe renal impairment, as the drug’s metabolism and clearance may be significantly impacted.

Side Effect

- The most common side effects associated with alfuzosin include dizziness, headache, and fatigue. These symptoms often resolve with continued use or dosage adjustment. - Other common side effects include orthostatic hypotension (a drop in blood pressure upon standing), which may cause dizziness, lightheadedness, or fainting. - Some individuals may experience nausea, dry mouth, or abdominal discomfort. - Rare but serious side effects include priapism (painful, prolonged erection), severe allergic reactions, and arrhythmias (irregular heartbeats). - In some cases, individuals may experience swelling in the feet, ankles, or legs (edema), which should be reported to a healthcare provider if persistent. - Allergic reactions, though rare, may present as rash, itching, or difficulty breathing, and in such cases, the patient should seek immediate medical attention. - There is a potential for blurred vision or other visual disturbances, especially in older adults. - Less common side effects include weight gain, chest pain, and shortness of breath, which may indicate more serious cardiovascular concerns. - Long-term use may increase the risk of cardiovascular events, so patients should be monitored for any new or unusual symptoms, especially if they have existing cardiovascular conditions.

Pregnancy Category ID

2

Mode of Action

- Alfuzosin is a selective alpha-1 adrenergic receptor blocker. It works by inhibiting the alpha-1 receptors in the smooth muscle of the prostate, bladder neck, and urethra. - By blocking these receptors, alfuzosin helps to relax the smooth muscles, thereby improving urine flow and alleviating symptoms of benign prostatic hyperplasia (BPH) such as difficulty urinating or weak urinary stream. - In addition to its effects on the prostate, alfuzosin also relaxes the blood vessels, which can contribute to its ability to lower blood pressure, although this is not its primary indication. - Alfuzosin has a high degree of selectivity for the alpha-1A receptor subtype, which is predominantly located in the prostate and bladder, thereby reducing the risk of unwanted cardiovascular side effects compared to non-selective alpha-blockers. - The drug’s action also helps to reduce bladder outlet obstruction, providing symptomatic relief to individuals suffering from BPH-related urinary issues. - Alfuzosin has a mild effect on blood pressure, primarily by causing vasodilation, which can help reduce the symptoms of hypertension in some patients, though it is not commonly prescribed for this purpose. - The drug's effects are typically seen within a few days of initiating therapy, with peak effects occurring after a few weeks of consistent use.

Interaction

- Alfuzosin may interact with medications that affect the cytochrome P450 3A4 enzyme, such as ketoconazole, itraconazole, and clarithromycin, which can increase the concentration of alfuzosin in the bloodstream and elevate the risk of severe hypotension. - When alfuzosin is used concurrently with other antihypertensive medications, particularly those that cause vasodilation (e.g., nitrates, ACE inhibitors), there is an increased risk of hypotension. Close monitoring is recommended. - Combining alfuzosin with other alpha-adrenergic blockers (such as prazosin, terazosin) can cause a cumulative hypotensive effect and should generally be avoided. - Use with phosphodiesterase type 5 inhibitors (e.g., sildenafil, tadalafil) may increase the risk of significant hypotension, particularly if alfuzosin is taken together with these medications. - Drugs that lower blood pressure, such as diuretics, may increase the hypotensive effect when used in combination with alfuzosin. - Alfuzosin may interfere with the metabolism of certain drugs, potentially altering their efficacy. Therefore, dose adjustments of co-administered medications may be required.

Pregnancy Category Note

Information not available

Adult Dose

- The usual adult dose of alfuzosin for the treatment of benign prostatic hyperplasia (BPH) is 10 mg once daily, taken after the same meal each day. - The extended-release formulation is preferred to ensure a more consistent drug release and minimize side effects. - The dose may be adjusted based on patient response and tolerance, but the maximum recommended dose should not exceed 10 mg daily. - If the patient misses a dose, they should take it as soon as they remember, unless it is nearly time for the next dose. In that case, they should skip the missed dose and continue their regular dosing schedule. Doubling the dose to make up for a missed dose is not recommended.

Child Dose

- Alfuzosin is not approved for use in children and is contraindicated for pediatric patients. Its safety and effectiveness in individuals under the age of 18 have not been established. - Therefore, no pediatric dosage recommendations are available, and alfuzosin should not be used in this population.

Renal Dose

- Alfuzosin should be used with caution in patients with renal impairment. For mild to moderate renal impairment (e.g., creatinine clearance 30-60 mL/min), the usual dose of 10 mg once daily is typically considered safe, but close monitoring is recommended. - Alfuzosin is contraindicated in patients with severe renal impairment (creatinine clearance <30 mL/min), as the drug’s metabolism and elimination may be significantly impaired, increasing the risk of adverse effects. - For patients with mild to moderate renal dysfunction, it is advisable to initiate treatment with the lowest possible dose and monitor renal function regularly to avoid complications.

Administration

Information not available