0.9% SODIUM CHLORIDE IRRIGATION USP [WELLPHARMA] Price in UAE

Overview

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This medicine contains an important and useful components, as it consists of
Sodium chlorideis available in the market in concentration

Name

Sodium chloride

Precaution

Before using Sodium Chloride in any formulation—oral, injectable, or irrigation—certain precautions must be observed: <ul> <li>Monitor electrolyte levels regularly during prolonged use to avoid hypernatremia or fluid overload.</li> <li>Use with caution in patients with conditions such as congestive heart failure, hypertension, renal impairment, or liver cirrhosis due to risk of fluid retention.</li> <li>Administer carefully in elderly patients or those with decreased cardiac reserve.</li> <li>Ensure sterility when using injectable or irrigation formulations to avoid introducing pathogens.</li> <li>In neonates and premature infants, strict control of fluid and electrolyte balance is required.</li> </ul>

Indication

Sodium Chloride is indicated for a wide variety of clinical uses, depending on its formulation: <ul> <li>Intravenous use: Treatment of fluid and electrolyte imbalances, hypovolemia, hyponatremia, and metabolic alkalosis.</li> <li>Oral use: As a sodium supplement in patients with sodium depletion.</li> <li>Irrigation: For cleansing of wounds, body cavities, catheters, and surgical areas.</li> <li>Inhalation: As a diluent for nebulization with bronchodilators or mucolytics.</li> <li>Dialysis: In peritoneal and hemodialysis solutions.</li> </ul>

Contra indication

Sodium Chloride is contraindicated in the following situations: <ul> <li>Hypernatremia (elevated serum sodium levels)</li> <li>Fluid retention states like pulmonary edema or severe heart failure</li> <li>Severe renal impairment with oliguria or anuria unless under strict medical supervision</li> <li>Uncontrolled hypertension (in sodium-restricted patients)</li> <li>Patients on low-sodium diets unless clinically necessary</li> </ul>

Side Effect

While generally well tolerated when used appropriately, Sodium Chloride may cause: <ul> <li>Common: Thirst, nausea, mild fluid retention</li> <li>Serious: Hypernatremia, pulmonary edema, hypertension, metabolic acidosis, venous thrombosis (with IV use)</li> <li>Local (IV use): Pain, swelling, or phlebitis at the injection site</li> <li>Inhaled form: Bronchospasm or cough in sensitive individuals</li> </ul>

Pregnancy Category ID

Information not available

Mode of Action

Sodium Chloride acts as an electrolyte replenisher, osmotic agent, and fluid balancer: <ul> <li>Maintains extracellular fluid volume and plasma osmolality</li> <li>Restores sodium ion levels, vital for neuromuscular function and acid-base equilibrium</li> <li>In irrigation: Provides mechanical cleansing without disrupting osmotic gradients</li> <li>Inhaled: Helps loosen and mobilize mucus in respiratory passages</li> </ul>

Interaction

Drug interactions with Sodium Chloride are relatively rare but may occur in certain clinical contexts: <ul> <li>Diuretics: May increase or decrease sodium loss depending on the type (loop vs. thiazide)</li> <li>Corticosteroids: May enhance sodium retention</li> <li>NSAIDs: May impair renal function, increasing risk of sodium and fluid retention</li> <li>Antihypertensives: High sodium intake can reduce their effectiveness</li> </ul>

Pregnancy Category Note

FDA Pregnancy Category: Not formally assigned (generally considered safe) <ul> <li>Sodium Chloride is naturally present in the human body and essential for fetal development.</li> <li>Safe for use during pregnancy when administered in appropriate doses.</li> <li>Excessive sodium intake should be avoided in preeclampsia or edema-prone pregnancies.</li> </ul>

Adult Dose

Dosing varies by formulation and indication: <ul> <li>IV Infusion (0.9% NaCl): 500ml to 1000ml over 4–8 hours for volume resuscitation; adjust based on clinical status.</li> <li>Oral supplementation: 1–3g/day for sodium depletion, divided doses.</li> <li>Irrigation: As needed; volume based on wound or cavity size.</li> </ul>

Child Dose

Doses in pediatric patients must be individualized: <ul> <li>IV Infusion: 20–40 ml/kg/day (maintenance) or higher in resuscitation; monitor electrolytes closely.</li> <li>Oral: 1–2 mEq/kg/day divided in multiple doses.</li> <li>Irrigation: Use cautiously; ensure sterility and volume control in neonates and infants.</li> </ul>

Renal Dose

In patients with renal impairment, Sodium Chloride should be used cautiously: <ul> <li>Monitor serum sodium, fluid status, and renal function frequently.</li> <li>Adjust infusion rates to avoid volume overload, especially in oliguria or anuria.</li> <li>Avoid routine sodium loading unless replacing documented losses.</li> </ul>

Administration

Sodium Chloride can be administered via different routes depending on the indication: <ul> <li>IV (Intravenous): Infused slowly; use central or peripheral line based on volume and duration.</li> <li>Oral: Dissolved in water and consumed; may be given with food to reduce GI discomfort.</li> <li>Irrigation: Applied directly using sterile technique.</li> <li>Inhalation: Nebulized with respiratory medications for airway clearance.</li> </ul> Always adhere to aseptic techniques and clinical guidelines when administering Sodium Chloride in any form.