0.9% SODIUM CHLORIDE IRRIGATION USP [WELLPHARMA] Injection/Solution for

What is 0.9% SODIUM CHLORIDE IRRIGATION USP [WELLPHARMA]

0.9% Sodium Chloride Irrigation USP [WELLPHARMA] is a sterile, non-pyrogenic solution designed for irrigation during surgical, medical, or diagnostic procedures. It contains sodium chloride (NaCl) dissolved in water for injection, at a concentration isotonic with body fluids, typically used for washing, rinsing, or soaking tissues and body cavities. This preparation is free of antimicrobial agents and is not intended for intravenous administration.

• Composition: Each 100 ml contains 0.9 g of sodium chloride.
• Purpose: Used primarily to cleanse wounds, surgical sites, catheters, or body cavities during procedures.
• Packaging: Available in large-volume plastic irrigation bags (3000ml) for use in hospital or clinical settings.
• Non-toxic and non-irritating: The solution is formulated to be gentle on tissues, minimizing the risk of damage.

This solution plays a vital role in maintaining sterile environments during procedures and supports the removal of blood, debris, or foreign material from surgical or diagnostic fields.

How to use 0.9% SODIUM CHLORIDE IRRIGATION USP [WELLPHARMA]

0.9% Sodium Chloride Irrigation should only be used as directed by a healthcare professional in sterile environments. It is not intended for intravenous infusion or parenteral administration.

• External irrigation: Use to flush wounds, surgical incisions, or body cavities such as the bladder or peritoneal space under sterile conditions.
• Wound cleansing: Gently squeeze the solution to irrigate contaminated wounds to remove debris and bacteria.
• Device rinsing: Commonly used for rinsing catheters, endoscopes, or surgical instruments before or after procedures.
• Administration: Should be delivered directly from the bag using an appropriate irrigation set or bulb syringe, maintaining aseptic technique.

Do not use this solution if the container is damaged, leaking, or shows signs of particulate matter. Single-use only—discard any unused portion after the procedure.

Mode of Action 0.9% SODIUM CHLORIDE IRRIGATION USP [WELLPHARMA]

The therapeutic activity of 0.9% Sodium Chloride Irrigation is mechanical rather than pharmacological. Its isotonicity plays a critical role in gentle tissue irrigation without altering osmotic gradients or damaging cells.

• Isotonic nature: Matches the osmolarity of body fluids, ensuring it neither draws fluid from tissues nor causes cellular swelling.
• Mechanical cleansing: Physically flushes out blood, contaminants, or tissue debris from wounds or surgical sites.
• Tissue compatibility: Non-irritant and non-toxic to mucosal surfaces and exposed tissues.
• Maintains hydration: Helps to keep exposed tissue moist during prolonged surgical procedures.

Because of its neutrality and non-pharmacologic activity, sodium chloride in irrigation acts mainly as a supportive agent for cleansing and hydration rather than altering any physiological processes.

0.9% SODIUM CHLORIDE IRRIGATION USP [WELLPHARMA] Interactions 0.9% SODIUM CHLORIDE IRRIGATION USP [WELLPHARMA]

As a non-systemic, sterile irrigating solution, 0.9% Sodium Chloride Irrigation does not exhibit systemic absorption under normal usage, minimizing the potential for drug interactions. However, certain considerations should be kept in mind:

• Topical medication dilution: When used concurrently with topical antiseptics or anesthetics, sodium chloride may dilute their concentration and effectiveness.
• Chemical incompatibilities: Should not be mixed with other irrigation solutions or medications unless compatibility has been established (e.g., silver nitrate, potassium permanganate).
• Device interactions: When used to flush catheters or scopes, ensure that the solution does not interfere with coating materials or sterilants.
• Contamination risk: Using the same container across procedures may introduce infection or alter the efficacy of previously applied medications.

Always consult institutional protocols before combining irrigation with other pharmaceutical or chemical agents.

Dosage of 0.9% SODIUM CHLORIDE IRRIGATION USP [WELLPHARMA]

Dosage of 0.9% Sodium Chloride Irrigation is not fixed but rather guided by the nature of the procedure, the volume required for effective irrigation, and the clinical judgment of the healthcare provider.

• General usage: Administer sufficient volume to thoroughly cleanse the area or device.
• Wound irrigation: Typically ranges from 100 ml to several liters, depending on wound size and level of contamination.
• Intraoperative use: Surgeons may use 500 ml to 3000 ml or more during procedures to maintain visibility and cleanliness.
• Bladder irrigation: May require intermittent or continuous irrigation using 1000–3000 ml per day, under controlled conditions.

Since it is a non-systemic preparation, there is no risk of overdose in healthy tissues. However, excessive irrigation should be avoided in closed body spaces without proper drainage.

Possible side effects of 0.9% SODIUM CHLORIDE IRRIGATION USP [WELLPHARMA]

When used correctly, 0.9% Sodium Chloride Irrigation is generally well tolerated. However, inappropriate use or contamination may lead to localized or systemic reactions.

• Local irritation: Redness or mild discomfort may occur if used in sensitive tissue areas.
• Infection: Improper handling or reusing containers may introduce pathogens, leading to wound infection or abscess formation.
• Electrolyte imbalance (rare): Excessive absorption during prolonged irrigation in large volumes may affect sodium levels in susceptible patients (e.g., infants or those with renal impairment).
• Allergic reactions: Extremely rare, but hypersensitivity to additives or materials used in the bag may trigger reactions.

If unusual symptoms such as persistent burning, edema, or signs of systemic infection arise, discontinue use and consult a healthcare provider immediately.

0.9% SODIUM CHLORIDE IRRIGATION USP [WELLPHARMA] Contraindications 0.9% SODIUM CHLORIDE IRRIGATION USP [WELLPHARMA]

Though generally safe, certain clinical situations may warrant avoiding or modifying the use of this solution.

• Hypersensitivity: Patients with known allergies to sodium chloride or bag materials should avoid use.
• Uncontrolled hemorrhage: Irrigation might obscure visualization of bleeding points during surgery.
• Closed spaces without drainage: Avoid excessive use in confined body cavities without proper fluid egress (e.g., pleural space).
• Use as an infusion: Not intended for intravenous use—should never be administered parenterally.

Clinical judgment is essential when using irrigation solutions in patients with impaired fluid balance or compromised renal function, where sodium retention could be problematic.

Storage of 0.9% SODIUM CHLORIDE IRRIGATION USP [WELLPHARMA]

Proper storage of irrigation solutions is essential to maintain sterility and efficacy, especially in hospital and clinical environments.

• Temperature: Store at 15°C to 30°C (59°F to 86°F), protected from freezing.
• Avoid sunlight: Keep in original overwrap until time of use to prevent light-induced degradation or contamination.
• Handling: Do not use if the solution appears cloudy, discolored, or contains particulate matter.
• Expiry: Observe expiration date on label. Do not use outdated products.
• Single-use container: Discard any unused solution immediately after opening. Do not store for future use once the bag has been breached.

Ensure that sterile field protocols are followed during storage and handling to reduce risk of contamination and infection.