COLIRCUSI DE ICOL Price in UAE

Overview

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This medicine contains an important and useful components, as it consists of
Chloramphenicol (sodium succinate), Dexamethasone Sodium phosphateis available in the market in concentration

Name

Chloramphenicol 0.5% + Dexamethasone 0.1% Eye&Ear drop

Precaution

Avoid prolonged use. Discontinue immediately if local hypersensitivity reactions occur.

Indication

Allergic conjunctivitis, Acute purulent conjunctivitis, Corneal ulceration, Keratitis disciformis, Post-herpetic keratitis, Allergic blepharitis, Acute and chronic iritis, Iridocyclitis, Otitis externa, infective and inflammatory ear infections.

Contra indication

History of hypersensitivity or toxic reaction to the drug; Perforated ear drum. Herpes simplex and other virul conditions of the eye or ear, mycosis.

Side Effect

Ophthalmic application: Hypersensitivity reactions including rashes, fever and angioedema. Ear drops: Ototoxicity.

Pregnancy Category ID

Mode of Action

Dexamethasone is a synthetic glucocorticoid which decreases inflammation by inhibiting the migration of leukocytes and reversal of increased capillary permeability. It suppresses normal immune response. Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.

Interaction

Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives. Potentially Fatal: Increases the effect of oral anticoagulants, oral hypoglycaemic agents, phenytoin. Avoid concomitant administration with drugs that depress bone marrow function.