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ARTHROTEC Price

Active Substance: Diclofenac sodium, Misoprostol.

36
UAD , based on 7541 reviews.
View Drug details

Overview

Welcome to Dwaey, specifically on ARTHROTEC Tablets page.
This medicine contains an important and useful components, as it consists of Diclofenac sodium, Misoprostol.
ARTHROTEC is available in the market in concentration 50mg, 200mg/Tablet and in the form of Tablets.

SEARLE PHARMACEUTICALS is the producer of ARTHROTEC and it is imported from UK, The most popular alternatives of ARTHROTEC are listed downward .

Mode Of Action

Diclofenac: Inhibits cyclooxygenase-1 (COX-1) & -2 (COX-2), thereby inhibiting prostaglandin synthesis; has anti-inflammatory, antipyresis, and analgesic properties. Misoprostol: Replaces protective prostaglandins consumed by prostaglandin-inhibiting therapies (NSAID-induced ulcers).

Indication

  • Rheumatoid arthritis
  • Osteoarthritis
  • Joint and muscular pains

Precaution

Patients with an underlying condition such as inflammatory bowel disease or those in whom dehydration should be monitored carefully if Diclofenac Sodium 50 mg plus Misoprostol 200 mcg is prescribed. The pharmacological activity in reducing fever and inflammation may diminish the utility of these diagnostic signs in detecting complications of presumed noninfectious, painful conditions. Lactation: Enters breast milk; use with caution

Side Effects

  • >10% Rash including erythematous
  • rash macular and maculo-papular (18%)
  • Pyrexia (15%)
  • Urticaria (13%)
  • Flushing (13%) 1-10% Hypertension (10%)
  • Hyperhydrosis (8%)
  • Decreased oxygen saturation (8%)
  • Cough (8%)
  • Tachypnea (8%)
  • Tachycardia (8%)
  • Urticaria (8%)
  • Anaphylaxis (7%)
  • Chest discomfort (7%)
  • Muscle twitching (7%)
  • Erythema (5%)
  • Vomiting (5%)
  • Rigors (5%)
  • Pallor (5%)
  • Cyanosis (5%)
  • Agitation (5%)
  • Tremor (5%)
  • Myalgia (5%)
  • Flushing (5%)
  • Peripheral edema (3%)
  • Pruritus (3%)
  • Rash
  • papular (3%)
  • Throat tightness (3%) <1% Fatigue
  • Malaise
  • Chills
  • Edema
  • Atrial fibrillation
  • Congestive heart failure
  • Myocardial infarction
  • Phlebitis
  • Vasculitis
  • Syncope
  • Dysphagia
  • Enteritis
  • Peptic ulcer
  • Vaginitis
  • Breast pain
  • Dysmenorrhea
  • Uterine cramping
  • Ulcerative stomatitis
  • Impotence
  • Perineal pain
  • Glycosuria
  • Alopecia

Contra indication

Diclofenac Sodium and Misoprostol combination is contraindicated in women who are pregnant because of the abortive property of the Misoprostol component.

Pregnancy and lactation

Pregnancy category: X

Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Interaction

May increase serum levels of methotrexate. Concomitant use w/ other NSAIDs or anticoagulants (e.g. warfarin) is associated w/ higher risk of GI bleeding. Increased risk of nephrotoxicity w/ ciclosporin or triamterene. May increase the risk of developing corneal complications in patients w/ significant pre-existing corneal inflammation when use concomitantly w/ ophth preparation containing corticosteroids. Colestyramine and colestipol reduce the bioavailability of diclofenac. Decreased plasma concentration when administered after sucralfate. Ophth application of diclofenac may reduce the efficacy of ophth acetylcholine and carbachol. May increase serum levels of lithium and digoxin. May increase effects of oxytocin. Increased risk of misoprostol-induced diarrhoea with magnesium-containing antacids.

Alternatives Price List

  • ARTHROTECUAD 36

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