ZELDOX 20mg/ml Price

Overview

Welcome to Dwaey, specifically on ZELDOX 20mg/ml page.
This medicine contains an important and useful components, as it consists of
Ziprasidone (as mesilatel)is available in the market in concentration

Name

Ziprasidone

Precaution

Patient w/ history of seizures or conditions that lower the seizure threshold, CV or cerebrovascular disease, conditions which predispose to hypotension. Renal impairment. Elderly w/ dementia-related psychosis. Pregnancy and lactation. Patient Counselling This drug may cause somnolence, impairment of judgment, thinking or motor skills, if affected, do not drive, operate machinery or perform hazardous tasks. Avoid alcohol. Monitoring Parameters Monitor serum electrolytes if on concurrent diuretic therapy. Monitor ECG in patients who show symptoms of torsades de pointes (e.g. syncope, dizziness, palpitations); wt gain. Closely monitor worsening of glucose control in patients w/ pre-existing DM. Frequently monitor CBC during 1st few mth of therapy in patients w/ pre-existing low leucocyte count or history of drug-induced leucopenia or neutropenia. Lactation: Unknown if excreted in breast milk; not recommended

Indication

Schizophrenia, Bipolar Disorder, Mania

Contra indication

Concomitant use of oral and IM ziprasidone. Recent acute MI, decompensated heart failure, cardiac arrhythmias, conditions that may increase QT interval eg, QT-interval prolongation or history of QT prolongation; prolactin dependent tumours. Lactation. Not for treatment of behavioural disorders in elderly with dementia.

Side Effect

>10% Somnolence (11-15%),Headache (11%),Nausea (4-12%),Extrapyramidal symptoms (2-31%),Dizziness (3-16%) 1-10% Respiratory disorders (1-8%),Constipation (2-9%),Dyspepsia (1-8%),Rash (4-5%),Tachycardia (2%),Hypoesthesia (2%),Priapism (1%),Orthostatic hypotension (5%),Xerostomia (1-5%),Anorexia (2%),Myalgia (2%),Rhinitis (1-4%),Cough (3%) <1% Syncope,Seizures Frequency Not Defined Prolongation of QT interval,Neuroleptic malignant syndrome (NMS),Hyperprolactinemia,Drug reaction with eosinophilia and systemic syntoms Potentially Fatal: Blood dyscrasias, neuroleptic malignant syndrome.

Pregnancy Category ID

3

Mode of Action

Ziprasidone, an atypical antipsychotic, produces antischizophrenic effect through a combination of dopamine D2 and serotonin 5H2 receptor antagonism.

Interaction

Antagonistic effect with levodopa and dopamine antagonists. Additive hypotensive effect with antihypertensives. Additive sedative effects with other CNS agents, alcohol. Potentially Fatal: Increased risk of torsades de pointes with drugs that prolong QT interval e.g. dofetilide, quinidine, sotalol, and other Class Ia and III antiarrhythmics, moxifloxacin, pimozide, sparfloxacin, thioridazine.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration