Active Substance: Mebendazole.
Overview
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This medicine contains an important and useful components, as it consists of
Mebendazoleis available in the market in concentration
Mebendazole
Hepatic impairment. Childn. Pregnancy and lactation. Monitoring Parameters Periodic assessment of haematologic, hepatic, and renal function; check for helminth ova in faeces w/in 3-4 wk following the initial therapy. Lactation: Excretion in breast milk unknown; use caution
Enterobiasis, Hookworm infections, Filariasis, Toxocariasis, Ascarisis, Trichuriasis, Trichostrongyliasis, Trichinellosis, Dracunculiasis
Hypersensitivity. Infants and children <2 yr.
Transient diarrhoea, abdominal pain, nausea, vomiting, headache, tinnitus, numbness, fever, alopecia, rash, pruritus, urticaria, angioedema, flushing, hiccups, cough, weakness, drowsiness, chills, hypotension, seizures, transient abnormalities in LFT (e.g. increased serum concentrations of aminotransferases, glutamyltransferase alkaline phosphatase, and/or bilirubin), hepatitis, increased BUN, decreased Hb concentration and/or hematocrit, leucopenia, eosinophilia, haematuria, cylindruria, migration of roundworms through the mouth and nose. Potentially Fatal: Myelosuppression, manifested as neutropenia (including agranulocytosis) and/or thrombocytopenia.
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Mebendazole inhibits formation of helminth microtubules. It selectively and irreversibly blocks the uptake of glucose and other nutrients in susceptible helminths, resulting in endogenous depletion of glycogen stores in the helminth.
Decreased plasma concentrations w/ carbamazepine and phenytoin. Increased plasma concentrations w/ cimetidine.
Information not available