TRACHISAN SORE THROAT GARGLE Price

Overview

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This medicine contains an important and useful components, as it consists of
Chlorhexidine gluconate, Lidocaine HClis available in the market in concentration

Name

Chlorhexidine Gluconate 0.25% + Lidocaine Hydrochloride

Precaution

Avoid contact w/ sensitive tissues and eyes. Do not use in body cavities.Avoid eating, drinking, or brushing your teeth just after using this medication

Indication

Acute sore throats

Contra indication

Hypersensitivity to any of the ingredients.

Side Effect

Skin sensitivity; reversible brown staining of the teeth; tongue discoloration and burning sensation; transient taste disturbance; parotid gland swelling. Potentially Fatal: Anaphylaxis.

Pregnancy Category ID

2

Mode of Action

Chlorhexidine is a very potent cationic chemoprophylactic agent that has a broad-spectrum of activity against gm+ve and gm-ve bacteria. It is both bacteriostatic and bactericidal depending on its concentration. The bactericidal effect, which is achieved at high concentrations, is due to the binding of the cationic to negatively charged bacterial cell walls and extramicrobial complexes. Bacteriostatic effect is achieved at low concentrations which causes an alteration of bacterial cell osmotic equilibrium and leakage of potassium and phosphorus. Lidocaine is an amide type local anaesth. It stabilises the neuronal membrane and inhibits Na ion movements, which are necessary for conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced.

Interaction

May increase serum levels w/ cimetidine and propranolol. Increased risk of cardiac depression w/ ?-blockers and other antiarrhythmics. Additive cardiac effects w/ IV phenytoin. Hypokalaemia caused by acetazolamide, loop diuretics and thiazides may antagonise effect of lidocaine. Dose requirements may be increased w/ long-term use of phenytoin and other enzyme-inducers.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration