TOPAMAX 50mg price in UAE

Overview

Welcome to Dwaey, specifically on TOPAMAX 50mg Tablets/film-coated page.
This medicine contains an important and useful components, as it consists of Topiramate.
TOPAMAX 50mg is available in the market in concentration 50mg/Tablet and in the form of Tablets/film-coated.

JANSSEN-CILAG AG is the producer of TOPAMAX 50mg and it is imported from SWITZERLAND, The most popular alternatives of TOPAMAX 50mg are listed downward .

Mode Of Action

Topiramate is a sulfamate-substituted monosaccharide with precise mechanism of action unknown. It may be due to various mechanisms e.g. blocking of voltage-dependent sodium channels; augmenting the activity of ?-aminobutyric acid (GABA) at GABA-A receptor; antagonising AMPA/kainate glutamate receptors; inhibiting carbonic anhydrase.

Indication

Epilepsy
Migraine prophylaxis
Seizures associated w/ Lennox-gastaut syndrome

Precaution

Renal or hepatic impairment, pregnancy, lactation. May impair ability to drive or operate machinery. Maintain adequate hydration to reduce the risk of renal calculi especially in predisposed patients. Measure serum bicarbonate at baseline and periodically during treatment. Avoid abrupt withdrawal; decrease dose by 100 mg daily at wkly intervals. Seek immediate medical attention if blurred vision or eye pain. Monitor closely for decreased sweating and increased body temperature, especially in hot weather. Ensure proper hydration before and during activities or exposure to warm temperatures. Lactation: Excreted in milk; use caution

Side Effects

>10% Decrease in serum bicarbonate (7-67%)
Dizziness (4-29%)
Fatigue (9-16%)
Ataxia (6-16%)
Nervousness (9-18%)
Paresthesia (1-11%)
Psychomotor slowing (3-13%)
Abnormal vision (2-13%)
Anorexia (4-24%)
Confusion (4-11%)
Decreased memory (2-12%)
Nausea (6-10%)
Speech disorder (2-13%)
Injury (14%) 1-10% Abdominal pain (6-10%)
Weight loss (4-9%)
Diplopia (1-10%)
Mood problems (<6%)
Pharyngitis (6%)
Tremor (3-9%)
Abnormal gait (3-8%)
Apathy (1%)
Asthenia (1-5%)
Dry mouth (2%)
Menorrhagia (1-2%)
Skin disorder (2-3%)
Taste change (2%)
Edema (2%)
Hypertension (1-2%)
Syncope (1%)
Bradycardia (1%)
Pallor (1%) <1% Angina
Erythema
Hepatic failure
Hyperthermia
Hypokalemia
Neuropathy
Toxic epidermal necrolysis

Contra indication

Contraindicated in persons showing hypersensitivity to any component of this preparation.

Pregnancy and lactation

Pregnancy category: D

There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Interaction

Coadmin with antiepileptic drugs e.g. phenytoin, carbamazepine, phenobarbital decreases plasma concentration of topiramate. Possible increase in phenytoin levels. Increased risk of renal stone formation with carbonic anhydrase inhibitors e.g. acetazolamide. Increased risk of CNS depression with CNS depressants and alcohol. Increased risk of hyperammonaemia and encephalopathy with valproic acid. Increased risk of contraceptive failure in women taking combined oral contraceptives.