Active Substance: Amantadine HCl.
Overview
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This medicine contains an important and useful components, as it consists of
Amantadine HClis available in the market in concentration
Amantadine Hydrochloride
Patients with CV or liver disease, impaired renal function, recurrent eczema. Elderly. Withdrawal of the drug should be gradual. Lactation: Drug enters breast milk; not recommended
Parkinson's disease, Influenza, herpes zoster, drug-induced extrapyramidal reactions
Hypersensitivity. Pregnancy and lactation. Epilepsy or other seizure disorders, severe renal impairment and gastric ulceration.
1-10% Agitation,Anorexia,Anxiety,Ataxia,Confusion,Constipation,Depression,Diarrhea,Dizziness,Dream abnormality,Dry nose,Fatigue,Hallucinations,Headache,Insomnia,Irritability,Livedo reticularis,Nausea,Nervousness,Orthostatic hypotension,Peripheral edema,Somnolence,Xerostomia <1% Amnesia,CHF,Decreased libido,Dyspnea,Eczematoid dermatitis,Euphoria,Hyperkinesis,Hypertension,Instances of convulsions,Leukopenia,Neutropenia,Oculogyric episodes,Psychosis,Rash,Slurred speech,Urinary retention,Visual disturbances,Vomiting,Weakness Potentially Fatal: Congestive heart failure, convulsions.
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Amantadine is a weak dopamine agonist possessing antimuscarinic properties. It alters dopamine release and re-uptake. It also noncompetitively antagonises N-methyl-D-aspartate. As an antiviral drug, it inhibits replication of influenza type A virus.
Enhances the adverse effects of antimuscarinics and levodopa. CNS stimulants, drugs that raise urinary pH. The concurrent use of Amantadine hydrochloride with live attenuated influenza vaccine (LAIV) intranasal has not been evaluated.
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