Ivermectin

Welcome to Dwaey, specifically on Ivermectin page.
This medicine contains important and useful components, as it consists of
Ivermectin is available in the market in concentration.

Generic Name of Ivermectin - Learn More

Ivermectin

Ivermectin Precaution - What You Need to Know

Before initiating ivermectin therapy, it is crucial to consult with your healthcare provider, especially if you have a history of liver disease, neurological disorders, or are pregnant or breastfeeding. Ivermectin is contraindicated in individuals with known hypersensitivity to the drug. Regular monitoring of liver function and neurological status is recommended during treatment. Additionally, ivermectin may interact with certain medications, including warfarin and other anticoagulants, potentially increasing the risk of bleeding. It is essential to inform your doctor about all medications you are currently taking to avoid adverse interactions. Patients should also be aware of potential side effects, such as dizziness, drowsiness, or skin reactions. Always follow your doctor's guidance regarding the use of ivermectin.

Ivermectin Indication - Uses and Benefits

Ivermectin is primarily prescribed for the treatment of parasitic infections, including:
- Onchocerciasis (River Blindness): Caused by the parasitic worm *Onchocerca volvulus*, leading to severe itching, skin changes, and potential blindness.
- Strongyloidiasis: An intestinal infection caused by the threadworm *Strongyloides stercoralis*, leading to gastrointestinal symptoms and potential systemic complications.
- Ascariasis: An intestinal infection caused by the roundworm *Ascaris lumbricoides*, leading to abdominal discomfort and potential malnutrition.
- Scabies: A skin infestation caused by the mite *Sarcoptes scabiei*, leading to intense itching and a rash.
- Head Lice: Infestation of the scalp by *Pediculus humanus capitis*, causing itching and discomfort.
- Rosacea: A chronic skin condition causing redness and visible blood vessels on the face.
Off-label uses of ivermectin include the treatment of other parasitic infections and certain skin conditions. Clinical guidelines recommend ivermectin as an effective treatment for these conditions, often as a first-line therapy.

Ivermectin Contraindications - Important Warnings

Ivermectin is contraindicated in:
- Individuals with Hypersensitivity: Known hypersensitivity to ivermectin or any of its components.
- Pregnant and Breastfeeding Women: Due to potential risks to the developing fetus or infant.
- Patients with Meningitis: Particularly in areas where onchocerciasis is endemic, as ivermectin can cross the blood-brain barrier and may exacerbate neurological conditions.
- Children Under 5 kg: Safety and efficacy have not been established in this population.
The rationale behind these contraindications is to prevent potential adverse effects that could arise from ivermectin's pharmacological properties, such as neurotoxicity or teratogenicity.

Ivermectin Side Effects - What to Expect

Common side effects of ivermectin include:
- Dizziness and Drowsiness: May impair the ability to perform tasks requiring alertness.
- Skin Reactions: Rashes or itching may occur, especially in the early stages of treatment.
- Gastrointestinal Symptoms: Nausea, vomiting, or diarrhea can occur.
- Neurological Effects: Headache, confusion, or seizures are rare but serious side effects.
If you experience severe or persistent side effects, seek medical attention promptly. To mitigate side effects, ivermectin should be taken with food.

Ivermectin Pregnancy Category ID - Safety Information

3

Ivermectin Mode of Action - How It Works

Ivermectin exerts its therapeutic effects by:
- Binding to Glutamate-Gated Chloride Channels: This binding enhances inhibitory neurotransmission in invertebrates, leading to paralysis and death of the parasite.
- Selective Action: Ivermectin has a high affinity for invertebrate-specific channels, minimizing effects on human cells.
This mechanism is distinctive because it targets the nervous and muscular systems of parasites without significantly affecting human cells, leading to its effectiveness and safety profile.

Ivermectin Drug Interactions - What to Avoid

Ivermectin has significant interactions with various substances:
- Drug-Drug Interactions: Concomitant use with drugs like warfarin may increase the risk of bleeding. Caution is advised when used with other medications metabolized by the liver.
- Food Interactions: Taking ivermectin with food can enhance its absorption, potentially increasing its effectiveness.
- Alcohol: Alcohol consumption should be limited during treatment, as it may increase the risk of liver toxicity.
To manage these interactions, it is essential to inform your healthcare provider about all medications and supplements you are taking before starting ivermectin therapy.

Ivermectin Adult Dose - Recommended Dosage

For adults, the dosing regimen varies based on the condition being treated:
- Onchocerciasis: A single dose of 150 micrograms per kilogram of body weight, repeated every 6 to 12 months.
- Strongyloidiasis: A single dose of 200 micrograms per kilogram of body weight.
- Scabies: A single dose of 200 micrograms per kilogram of body weight, repeated after 2 weeks if necessary.
- Head Lice: A single dose of 200 micrograms per kilogram of body weight, repeated after 2 weeks if necessary.
Dosage adjustments may be necessary for individuals with liver or kidney impairment.

Ivermectin Child Dose - Dosage for Children

For pediatric patients, dosing varies depending on the condition being treated and the child's weight.
- For Strongyloidiasis or Scabies: Doses of 200 micrograms per kilogram of body weight for a single dose.
- For Onchocerciasis: Dosing also follows the adult regimen, adjusted by weight and clinical response.
Due to the potential for serious side effects, especially in children under 5 kg, close monitoring is necessary. Always consult a pediatric specialist before initiating treatment.

Ivermectin Renal Dose - Dosage for Kidney Conditions

In patients with renal impairment:
- Mild to Moderate Impairment: No dosage adjustment is necessary.
- Severe Impairment: Use with caution; consider dose reduction and increased monitoring.
Regular monitoring of renal function during therapy is essential.