Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate (Rectal prep)

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Generic Name of Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate (Rectal prep) - Learn More

Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate (Rectal prep)

Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate (Rectal prep) Precaution - What You Need to Know

Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate is a topical combination therapy often used in rectal preparations. It is important to exercise caution in certain populations, such as pregnant and breastfeeding women. This combination is classified under category C for pregnancy, indicating that there are no well-controlled studies in pregnant women, but the potential benefits may warrant its use despite possible risks. During breastfeeding, it is unknown if the components of this preparation are excreted in breast milk, and therefore, it should be used cautiously. Patients with a history of hypersensitivity to any component of the drug, especially neomycin or corticosteroids, should avoid its use. Caution is also advised in individuals with conditions like diabetes, as corticosteroids can increase blood glucose levels. Additionally, due to the hydrocortisone component, prolonged use or application over large areas can increase the risk of systemic absorption and may lead to adrenal suppression. Monitoring for local irritation, skin thinning, or infection is essential during prolonged treatment. Misuse or excessive application, especially in large areas or broken skin, can lead to systemic side effects, particularly related to the corticosteroid component.

Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate (Rectal prep) Indication - Uses and Benefits

This combination product is indicated for the treatment of hemorrhoidal symptoms such as pain, itching, and inflammation. The active ingredients—Cinchocaine Hydrochloride, a local anesthetic, Esculin, a vascular protectant, Hydrocortisone, an anti-inflammatory, and Neomycin Sulphate, an antibiotic—work together to provide symptomatic relief. The anesthetic action of Cinchocaine helps numb the affected area, while Hydrocortisone reduces inflammation and swelling, and Esculin aids in the protection of blood vessels. Neomycin Sulphate is included to help prevent or treat secondary bacterial infections in the area, which can complicate hemorrhoidal conditions. This product may also be used off-label to manage pruritis ani or other rectal conditions involving inflammation or irritation. However, it is typically considered for short-term use due to potential adverse effects with prolonged application, especially the steroid component, which can lead to skin thinning or other systemic effects with long-term use.

Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate (Rectal prep) Contraindications - Important Warnings

The combination preparation should be avoided in patients with a known hypersensitivity to any of its components, including Cinchocaine, Esculin, Hydrocortisone, or Neomycin. Contraindications include active infections of the skin or rectal area, especially fungal, viral, or tuberculosis-related infections, as the hydrocortisone component may exacerbate such conditions. This product should not be used for long periods in patients with a history of skin conditions like dermatitis or those with an impaired immune response, as corticosteroids can impair wound healing and increase susceptibility to infections. Additionally, caution is advised in patients with a history of kidney or liver disease, as Neomycin can be nephrotoxic, and prolonged use may lead to systemic absorption and toxicity. The product is contraindicated in patients with perforation or a history of gastrointestinal ulcers or other related complications, as the corticosteroid may aggravate these conditions.

Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate (Rectal prep) Side Effects - What to Expect

The side effects of Cinchocaine Hydrochloride + Esculin + Hydrocortisone + Neomycin Sulphate are generally localized to the area of application and include skin irritation, redness, or burning. This is typically mild and resolves with discontinuation or reduction in frequency of application. Prolonged use of hydrocortisone can lead to skin thinning, delayed wound healing, and increased susceptibility to secondary infections. Neomycin, being an antibiotic, can occasionally cause allergic reactions, including rash, itching, or more severe reactions such as anaphylaxis, though these are rare. Additionally, prolonged use of the product can lead to the development of contact dermatitis or perianal fungal infections due to the steroid content. Rare but serious side effects include systemic absorption of corticosteroids, leading to adrenal suppression, hyperglycemia, or fluid retention. Patients should immediately report symptoms such as increased swelling, unusual fatigue, or weight gain, as these may indicate systemic steroid effects. If a bacterial or fungal infection develops in the treated area, it may require discontinuation of the preparation and a change in therapy.

Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate (Rectal prep) Mode of Action - How It Works

Cinchocaine Hydrochloride acts as a local anesthetic, blocking nerve signals in the affected area by inhibiting the conduction of sodium ions through nerve membranes, which prevents pain transmission. This provides immediate relief from the discomfort associated with hemorrhoids or other anal irritation. Esculin is a saponin glycoside that possesses anti-inflammatory and vasoprotective properties. It helps reduce capillary permeability and protects the blood vessels in the rectal region from damage, reducing swelling and irritation. Hydrocortisone, a corticosteroid, exerts its anti-inflammatory effects by inhibiting the release of pro-inflammatory mediators, reducing local inflammation and edema. It also works to modulate immune responses in the affected area, providing relief from the itching and swelling that often accompany hemorrhoidal conditions. Neomycin Sulphate is an antibiotic that targets a broad spectrum of bacteria, preventing or treating secondary bacterial infections in the rectal area. Its antimicrobial properties help protect the affected region from potential infections that may occur due to the presence of hemorrhoids or irritation.

Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate (Rectal prep) Drug Interactions - What to Avoid

This topical combination does not have many significant systemic drug-drug interactions due to its localized application. However, systemic absorption of Hydrocortisone and Neomycin can lead to potential interactions with oral corticosteroids or other nephrotoxic medications, especially in individuals who are using multiple medications or have kidney issues. Caution should be exercised when using this preparation in conjunction with other products containing corticosteroids, as excessive steroid exposure can lead to adrenal suppression, especially with prolonged use. Neomycin Sulphate can also interact with other antibiotics, particularly those that have nephrotoxic effects like aminoglycosides, which may increase the risk of renal damage. Patients should avoid using this product concurrently with other topical antibiotics to prevent redundancy and reduce the risk of developing resistant bacterial strains. For those using multiple topical products, it is advised to wait for a period of time between applications to prevent possible interactions and reduce irritation.

Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate (Rectal prep) Adult Dose - Recommended Dosage

For adults, Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate is typically applied to the affected area 2-3 times a day, or as directed by a healthcare provider. The preparation should be applied sparingly to the rectal area after bowel movements or as needed for symptom relief. It is important to use the preparation as directed to avoid excessive use of corticosteroids, which can lead to skin thinning or other adverse effects. Application should be done after cleansing the affected area to ensure the medication is not diluted or removed prematurely. It is advised to use this preparation for a limited period, generally no more than one to two weeks, to avoid complications associated with prolonged corticosteroid use.

Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate (Rectal prep) Child Dose - Dosage for Children

This combination preparation is typically not recommended for pediatric use unless specifically directed by a healthcare provider. Children may be more susceptible to the systemic effects of corticosteroids, and prolonged use of hydrocortisone can result in significant side effects such as growth suppression, delayed wound healing, and adrenal suppression. Additionally, the Neomycin component may increase the risk of developing a hypersensitivity reaction or systemic infection in children. If prescribed for pediatric patients, careful monitoring of the rectal area is necessary to prevent potential complications such as skin thinning or local infections. The dose for children would need to be adjusted based on the severity of the condition and the child's response to treatment, but long-term use should be avoided. Always consult a pediatric healthcare provider before using this product in children.

Cinchocaine Hydrochloride 0.5% + Esculin 1% + Hydrocortisone + Neomycin Sulphate (Rectal prep) Renal Dose - Dosage for Kidney Conditions

Although the rectal preparation is intended for local use, Neomycin Sulphate, one of its active components, can be systemically absorbed, especially in patients with impaired renal function. In patients with renal impairment, Neomycin may accumulate, potentially leading to nephrotoxicity. Therefore, patients with renal disease should use this product with caution, and renal function should be monitored regularly. For individuals with severe renal impairment, it may be advisable to limit the use of products containing Neomycin due to the risk of systemic absorption. Adjustments to dosage frequency may be required, and it may be necessary to avoid prolonged use of this medication.