ALDACTONE 100 Tablets

What is ALDACTONE 100

ALDACTONE 100 is a high-dose formulation of spironolactone, a potassium-sparing diuretic and aldosterone antagonist. It’s available as 100 mg scored tablets, typically in packs of 10.

• Pharmaceutical class: Mineralocorticoid receptor blocker; potassium-sparing diuretic.
• Main indications:
  • Hypertension—especially resistant cases
  • Heart failure with reduced ejection fraction (NYHA II–IV)
  • Edema due to liver cirrhosis, nephrotic syndrome, or renal impairment
  • Primary hyperaldosteronism (both pre-surgery and maintenance) :contentReference[oaicite:1]{index=1}
• Additional off-label uses: Acne, hirsutism, polycystic ovary syndrome (PCOS), and female-pattern hair loss—due to spironolactone's anti-androgen effects :contentReference[oaicite:2]{index=2}.
• Mechanism summary: Blocks aldosterone, promoting sodium and water excretion while retaining potassium.

How to use ALDACTONE 100

Only take ALDACTONE 100 under medical supervision. Use exactly as prescribed.

• Administration: Oral, with or without food. Aim for consistent dosing timing daily. :contentReference[oaicite:3]{index=3}
• Initial dosing:
  • Hypertension/heart failure: 25–100 mg once daily (can split dosing). :contentReference[oaicite:4]{index=4}
  • Edema: Start at 100 mg daily, titrate slowly. :contentReference[oaicite:5]{index=5}
  • Primary hyperaldosteronism: 100–400 mg daily, individually adjusted. :contentReference[oaicite:6]{index=6}
• Titration: Adjust based on response, serum potassium, and kidney function.
• Monitoring: Regularly assess electrolytes (especially potassium), blood pressure, renal function, and signs of dehydration. :contentReference[oaicite:7]{index=7}
• Missed dose: Skip if close to next dose; do not double up.
• Duration: Often long-term in chronic conditions; may be short-term in acute scenarios.

Mode of Action ALDACTONE 100

Spironolactone works through dual pharmacological mechanisms:

• Aldosterone antagonism: Blocks mineralocorticoid receptors in distal renal tubules → increased sodium/water excretion and reduced potassium loss. This helps lower blood pressure and reduce edema. :contentReference[oaicite:8]{index=8}
• Weak anti-androgen effects: Competitively inhibits androgen receptors and testosterone synthesis—useful for acne and hirsutism. Often reserved for females due to risks in males. :contentReference[oaicite:9]{index=9}
• Cardiovascular impact: Improves heart failure outcomes by reducing fibrosis and remodeling; diuretic action decreases preload/afterload. :contentReference[oaicite:10]{index=10}

ALDACTONE 100 Interactions ALDACTONE 100

Spironolactone interacts with several medications and dietary elements:

• Potassium-impacting agents: ACE inhibitors, ARBs, potassium supplements—risk of hyperkalemia. Monitor K+ closely. :contentReference[oaicite:11]{index=11}
• Eplerenone: Contraindicated concurrently. :contentReference[oaicite:12]{index=12}
• NSAIDs: Reduce diuretic efficacy; small increase in hyperkalemia risk. :contentReference[oaicite:13]{index=13}
• Lithium: Increased lithium levels—monitor due to increased neurotoxicity risk. :contentReference[oaicite:14]{index=14}
• Digoxin: May interfere with monitoring assays—use caution. :contentReference[oaicite:15]{index=15}
• Cholestyramine: May increase hyperkalemic metabolic acidosis risk. :contentReference[oaicite:16]{index=16}
• Licorice: Can counteract spironolactone’s effects. :contentReference[oaicite:17]{index=17}

Dosage of ALDACTONE 100

Specific dosing is condition-dependent:

• Heart failure (NYHA II–IV): Begin at 25 mg daily, up to 50 mg for maintenance. Maximum 100 mg, as tolerated. :contentReference[oaicite:18]{index=18}
• Hypertension: 25–100 mg daily in one or two doses. :contentReference[oaicite:19]{index=19}
• Edema: Start at 100 mg/day; may need titration. :contentReference[oaicite:20]{index=20}
• Primary hyperaldosteronism: 100–400 mg founded pre-operatively or for long-term control. :contentReference[oaicite:21]{index=21}
• Off-label acne/hirsutism: Often 50–100 mg daily; tailored by dermatologist. :contentReference[oaicite:22]{index=22}
• Monitoring: Start low in elderly or renal impairment; adjust based on electrolytes and kidney function.

Possible side effects of ALDACTONE 100

Common and serious reactions include:

• Common: Dizziness, headache, gastrointestinal upset, lethargy, orthostatic hypotension. :contentReference[oaicite:23]{index=23}
• Endocrine: Gynecomastia, decreased libido (males); menstrual irregularities, breast pain (females). Often dose-related and reversible. :contentReference[oaicite:24]{index=24}
• Electrolyte imbalances: Hyperkalemia—can cause arrhythmias; hyponatremia. :contentReference[oaicite:25]{index=25}
• Renal impairment: Increased BUN/creatinine from volume depletion—monitor kidney function. :contentReference[oaicite:26]{index=26}
• Dermatologic: Rash, pruritus, Stevens-Johnson syndrome or TEN (rare). :contentReference[oaicite:27]{index=27}
• Hematologic: Rare leukopenia, thrombocytopenia. :contentReference[oaicite:28]{index=28}
• Hepatic: Rare cholestatic hepatitis. :contentReference[oaicite:29]{index=29}
• Other: Muscle cramps, confusion, lethargy, hyponatremia. :contentReference[oaicite:30]{index=30}

Regular monitoring and dose adjustments can minimize risks; discontinue if life-threatening side effects appear.

ALDACTONE 100 Contraindications ALDACTONE 100

• Absolute: Hyperkalemia (>5.0 mmol/L), Addison’s disease, anuria, acute renal insufficiency, concomitant eplerenone use. :contentReference[oaicite:31]{index=31}
• Relative/Caution:
  • Chronic renal or hepatic impairment
  • Volume depletion or salt-depletion
  • Elderly (increased risk of hypotension/hyperkalemia)
  • Pregnancy: Animal data suggests fetal effects—avoid unless necessary :contentReference[oaicite:32]{index=32}
  • Breastfeeding: Minimal transfer; caution advised. :contentReference[oaicite:33]{index=33}

Storage of ALDACTONE 100

• Temperature: Store at room temperature, below 25 °C (77 °F), away from extreme heat or cold. :contentReference[oaicite:34]{index=34}
• Light & moisture: Keep in original bottle/blister to protect from humidity and light.
• Expiry: Do not use after printed date.
• Child safety: Keep out of reach of children; secure storage essential.
• Disposal: Return unused tablets to pharmacy—avoid household waste.