What is ALDACTONE 100
ALDACTONE 100 is a high-dose formulation of spironolactone, a potassium-sparing diuretic and aldosterone antagonist. It’s available as 100 mg scored tablets, typically in packs of 10.
- Pharmaceutical class: Mineralocorticoid receptor blocker; potassium-sparing diuretic.
- Main indications:
- Hypertension—especially resistant cases
- Heart failure with reduced ejection fraction (NYHA II–IV)
- Edema due to liver cirrhosis, nephrotic syndrome, or renal impairment
- Primary hyperaldosteronism (both pre-surgery and maintenance) :contentReference[oaicite:1]{index=1}
- Additional off-label uses: Acne, hirsutism, polycystic ovary syndrome (PCOS), and female-pattern hair loss—due to spironolactone's anti-androgen effects :contentReference[oaicite:2]{index=2}.
- Mechanism summary: Blocks aldosterone, promoting sodium and water excretion while retaining potassium.
How to use ALDACTONE 100
Only take ALDACTONE 100 under medical supervision. Use exactly as prescribed.
- Administration: Oral, with or without food. Aim for consistent dosing timing daily. :contentReference[oaicite:3]{index=3}
- Initial dosing:
- Hypertension/heart failure: 25–100 mg once daily (can split dosing). :contentReference[oaicite:4]{index=4}
- Edema: Start at 100 mg daily, titrate slowly. :contentReference[oaicite:5]{index=5}
- Primary hyperaldosteronism: 100–400 mg daily, individually adjusted. :contentReference[oaicite:6]{index=6}
- Titration: Adjust based on response, serum potassium, and kidney function.
- Monitoring: Regularly assess electrolytes (especially potassium), blood pressure, renal function, and signs of dehydration. :contentReference[oaicite:7]{index=7}
- Missed dose: Skip if close to next dose; do not double up.
- Duration: Often long-term in chronic conditions; may be short-term in acute scenarios.
Mode of Action ALDACTONE 100
Spironolactone works through dual pharmacological mechanisms:
- Aldosterone antagonism: Blocks mineralocorticoid receptors in distal renal tubules → increased sodium/water excretion and reduced potassium loss. This helps lower blood pressure and reduce edema. :contentReference[oaicite:8]{index=8}
- Weak anti-androgen effects: Competitively inhibits androgen receptors and testosterone synthesis—useful for acne and hirsutism. Often reserved for females due to risks in males. :contentReference[oaicite:9]{index=9}
- Cardiovascular impact: Improves heart failure outcomes by reducing fibrosis and remodeling; diuretic action decreases preload/afterload. :contentReference[oaicite:10]{index=10}
ALDACTONE 100 Interactions ALDACTONE 100
Spironolactone interacts with several medications and dietary elements:
- Potassium-impacting agents: ACE inhibitors, ARBs, potassium supplements—risk of hyperkalemia. Monitor K+ closely. :contentReference[oaicite:11]{index=11}
- Eplerenone: Contraindicated concurrently. :contentReference[oaicite:12]{index=12}
- NSAIDs: Reduce diuretic efficacy; small increase in hyperkalemia risk. :contentReference[oaicite:13]{index=13}
- Lithium: Increased lithium levels—monitor due to increased neurotoxicity risk. :contentReference[oaicite:14]{index=14}
- Digoxin: May interfere with monitoring assays—use caution. :contentReference[oaicite:15]{index=15}
- Cholestyramine: May increase hyperkalemic metabolic acidosis risk. :contentReference[oaicite:16]{index=16}
- Licorice: Can counteract spironolactone’s effects. :contentReference[oaicite:17]{index=17}
Dosage of ALDACTONE 100
Specific dosing is condition-dependent:
- Heart failure (NYHA II–IV): Begin at 25 mg daily, up to 50 mg for maintenance. Maximum 100 mg, as tolerated. :contentReference[oaicite:18]{index=18}
- Hypertension: 25–100 mg daily in one or two doses. :contentReference[oaicite:19]{index=19}
- Edema: Start at 100 mg/day; may need titration. :contentReference[oaicite:20]{index=20}
- Primary hyperaldosteronism: 100–400 mg founded pre-operatively or for long-term control. :contentReference[oaicite:21]{index=21}
- Off-label acne/hirsutism: Often 50–100 mg daily; tailored by dermatologist. :contentReference[oaicite:22]{index=22}
- Monitoring: Start low in elderly or renal impairment; adjust based on electrolytes and kidney function.
Possible side effects of ALDACTONE 100
Common and serious reactions include:
- Common: Dizziness, headache, gastrointestinal upset, lethargy, orthostatic hypotension. :contentReference[oaicite:23]{index=23}
- Endocrine: Gynecomastia, decreased libido (males); menstrual irregularities, breast pain (females). Often dose-related and reversible. :contentReference[oaicite:24]{index=24}
- Electrolyte imbalances: Hyperkalemia—can cause arrhythmias; hyponatremia. :contentReference[oaicite:25]{index=25}
- Renal impairment: Increased BUN/creatinine from volume depletion—monitor kidney function. :contentReference[oaicite:26]{index=26}
- Dermatologic: Rash, pruritus, Stevens-Johnson syndrome or TEN (rare). :contentReference[oaicite:27]{index=27}
- Hematologic: Rare leukopenia, thrombocytopenia. :contentReference[oaicite:28]{index=28}
- Hepatic: Rare cholestatic hepatitis. :contentReference[oaicite:29]{index=29}
- Other: Muscle cramps, confusion, lethargy, hyponatremia. :contentReference[oaicite:30]{index=30}
Regular monitoring and dose adjustments can minimize risks; discontinue if life-threatening side effects appear.
ALDACTONE 100 Contraindications ALDACTONE 100
- Absolute: Hyperkalemia (>5.0 mmol/L), Addison’s disease, anuria, acute renal insufficiency, concomitant eplerenone use. :contentReference[oaicite:31]{index=31}
- Relative/Caution:
- Chronic renal or hepatic impairment
- Volume depletion or salt-depletion
- Elderly (increased risk of hypotension/hyperkalemia)
- Pregnancy: Animal data suggests fetal effects—avoid unless necessary :contentReference[oaicite:32]{index=32}
- Breastfeeding: Minimal transfer; caution advised. :contentReference[oaicite:33]{index=33}
Storage of ALDACTONE 100
- Temperature: Store at room temperature, below 25 °C (77 °F), away from extreme heat or cold. :contentReference[oaicite:34]{index=34}
- Light & moisture: Keep in original bottle/blister to protect from humidity and light.
- Expiry: Do not use after printed date.
- Child safety: Keep out of reach of children; secure storage essential.
- Disposal: Return unused tablets to pharmacy—avoid household waste.
ALDACTONE 100 features an exceptional active ingredient renowned for its potent effects, comprising Spironolactone. This powerful formulation provides a superior solution for addressing diverse health concerns. With 100mg/Tablet concentration and an easily manageable Tablets, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ALDACTONE 100 .
Welcome to Dwaey, specifically on ALDACTONE 100 page.
This medicine contains an important and useful components, as it consists of Spironolactone.
ALDACTONE 100 is available in the market in concentration 100mg/Tablet and in the form of Tablets.
SEARLE PHARMACEUTICALS is the producer of ALDACTONE 100 and it is imported from UK,
The most popular alternatives of ALDACTONE 100 are listed downward .
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Frequently Asked Questions
ALDACTONE 100 should be stored according to the instructions provided by SEARLE PHARMACEUTICALS.
In general, it is recommended to store ALDACTONE 100 in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ALDACTONE 100 may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ALDACTONE 100 for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ALDACTONE 100. Some medications, including
ALDACTONE 100, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ALDACTONE 100, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ALDACTONE 100 without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ALDACTONE 100 if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ALDACTONE 100 during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 100mg/Tablet,
and the specific recommendations of SEARLE PHARMACEUTICALS.
The effects of ALDACTONE 100 on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 100mg/Tablet, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ALDACTONE 100 with or without food may vary depending on the medication
and the recommendations of SEARLE PHARMACEUTICALS. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ALDACTONE 100 in children or elderly individuals may depend on various factors, including
the specific medication, type Tablets, and the recommendations of SEARLE PHARMACEUTICALS. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ALDACTONE 100 in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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