ALDACTONE 25 Tablets

What is ALDACTONE 25

ALDACTONE 25 is an oral medication containing 25 mg of spironolactone, a potassium-sparing diuretic and aldosterone receptor antagonist. Distributed in a bulk pack of 500 tablets, it’s designed for chronic conditions requiring sustained therapy.

• Drug class: Potassium-sparing diuretic; mineralocorticoid receptor antagonist :contentReference[oaicite:1]{index=1}.
• Primary uses: Management of edema (due to heart failure, cirrhosis, nephrotic syndrome), essential hypertension, primary hyperaldosteronism, and heart failure with reduced ejection fraction :contentReference[oaicite:2]{index=2}.
• Off-label applications: Treatment of acne, hirsutism, PCOS, and female-pattern hair loss due to androgen-blocking effects :contentReference[oaicite:3]{index=3}.
• Advantages of low-dose (25 mg): Allows fine-tuning of dosage, minimizes side effects like gynecomastia and electrolyte disturbances.
• Chronic treatment: Suitable for long-term administration in conditions like resistant hypertension or congestive heart failure.

How to use ALDACTONE 25

Use ALDACTONE 25 exactly as prescribed. Oral administration timing and monitoring are essential for safety and efficacy.

• Administration: Swallow whole with water, with or without food; consistent timing daily—often in the morning. Avoid late-day dosing to prevent nocturia :contentReference[oaicite:4]{index=4}.
• Dosing schedule: Usually once daily; high doses may be split, with the second dose taken before 4 pm :contentReference[oaicite:5]{index=5}.
• Missed dose: Take as soon as possible unless next dose is near—never double doses :contentReference[oaicite:6]{index=6}.
• Monitoring: Regular blood tests for potassium, sodium, creatinine; blood pressure checks; assess for dizziness or dehydration :contentReference[oaicite:7]{index=7}.
• Hydration status: Maintain adequate fluid intake; avoid abrupt discontinuation—taper only under medical supervision.
• Long-term adherence: Often lifelong treatment in chronic conditions; regular reviews ensure safe ongoing use.

Mode of Action ALDACTONE 25

ALDACTONE 25 works through multiple mechanisms:

• Aldosterone antagonism: Binds to mineralocorticoid receptors in the kidney, reducing sodium and water reabsorption while conserving potassium and hydrogen ion excretion :contentReference[oaicite:8]{index=8}.
• Diuretic effect: Weak natriuretic action primarily in the collecting ducts; often used with loop or thiazide diuretics to enhance fluid removal :contentReference[oaicite:9]{index=9}.
• Cardioprotective actions: Prevents cardiac fibrosis and remodeling, thereby reducing hospitalizations and improving mortality in HFrEF :contentReference[oaicite:10]{index=10}.
• Anti-androgenic properties: Blocks androgen receptors and inhibits testosterone conversion—beneficial for conditions like acne and hirsutism—but can lead to endocrine side effects :contentReference[oaicite:11]{index=11}.

ALDACTONE 25 Interactions ALDACTONE 25

Spironolactone interacts with multiple medications and supplements:

• Drugs increasing potassium: ACE inhibitors, ARBs, potassium supplements, NSAIDs, eplerenone—all increase risk of hyperkalemia :contentReference[oaicite:12]{index=12}.
• Lithium: Levels may rise due to reduced renal clearance—monitor for toxicity :contentReference[oaicite:13]{index=13}.
• Digoxin: Serum levels may increase, risking toxicity; monitor cardiac status :contentReference[oaicite:14]{index=14}.
• Diuretics: Loop/thiazide combos may enhance diuresis but elevate risk of electrolyte imbalance.
• Cholestyramine: May increase spironolactone-induced hyperkalemia risk :contentReference[oaicite:15]{index=15}.
• Herbal/food interactions: Potassium-rich foods (e.g., salt substitutes, bananas) and licorice can exacerbate or reduce drug efficacy :contentReference[oaicite:16]{index=16}.

Dosage of ALDACTONE 25

The dosage is individualized based on indication and patient factors:

• Hypertension: 25–100 mg daily—start at 25 mg and titrate in 25 mg increments every 2 weeks; doses >100 mg/day offer limited additional benefit :contentReference[oaicite:17]{index=17}.
• Edema: 25–200 mg/day in divided doses depending on clinical response :contentReference[oaicite:18]{index=18}.
• Heart failure: 25 mg daily; increase to 50 mg if tolerated; maintenance usually ≤100 mg :contentReference[oaicite:19]{index=19}.
• Primary hyperaldosteronism: 100–400 mg daily—typically starts at 100 mg and titrates upward :contentReference[oaicite:20]{index=20}.
• Hypokalemia: 25–100 mg daily :contentReference[oaicite:21]{index=21}.
• Acne/hirsutism: Off-label dosing usually 50–150 mg daily in females :contentReference[oaicite:22]{index=22}.
• Special populations: Elderly and renal impairment may require lower dosing (12.5–25 mg); frequent monitoring advised.

Possible side effects of ALDACTONE 25

While generally well tolerated, common and serious effects may occur:

• Common: Dizziness, headache, gastrointestinal discomfort, muscle cramps, lethargy, orthostatic hypotension :contentReference[oaicite:23]{index=23}.
• Endocrine: Gynecomastia/tenderness in males; menstrual irregularities, breast tenderness in females :contentReference[oaicite:24]{index=24}.
• Electrolyte imbalance: Hyperkalemia (arrhythmia risk), hyponatremia :contentReference[oaicite:25]{index=25}.
• Renal dysfunction: Worsened in dehydration or renal impairment :contentReference[oaicite:26]{index=26}.
• Rare severe reactions: Rash, pruritus, agranulocytosis, liver dysfunction, Stevens-Johnson syndrome :contentReference[oaicite:27]{index=27}.

ALDACTONE 25 Contraindications ALDACTONE 25

Contraindications include:

• Absolute: Hyperkalemia (serum K+ >5 mmol/L), anuria, acute renal insufficiency, Addison’s disease, known spironolactone allergy, concurrent eplerenone usage :contentReference[oaicite:28]{index=28}.
• Relative/Caution: Chronic kidney/liver disease, diabetes, elderly, dehydration, pregnancy (feminizing potential), lactation (excreted in milk) :contentReference[oaicite:29]{index=29}.

Storage of ALDACTONE 25

Proper storage preserves drug efficacy and safety:

• Temperature: Store at 20–25 °C (68–77 °F); avoid extremes :contentReference[oaicite:30]{index=30}.
• Packaging: Keep in original bottle to protect from light and moisture.
• Expiry: Do not use beyond printed date.
• Child safety: Keep locked or stored out of children’s reach.
• Disposal: Return unused tablets to collection programs—do not flush or discard with household waste.