What is ALDACTONE 25
ALDACTONE 25 is a low‑dose oral formulation of spironolactone, available in 25 mg scored tablets, typically supplied in packs of 20. Spironolactone is a potassium‑sparing diuretic and aldosterone receptor antagonist used in diverse clinical scenarios.
- Drug class: Mineralocorticoid receptor antagonist; potassium‑sparing diuretic :contentReference[oaicite:1]{index=1}.
- Primary indications: Hypertension (especially resistant), congestive heart failure, fluid retention due to liver or kidney disease, primary hyperaldosteronism :contentReference[oaicite:2]{index=2}.
- Off-label uses: Acne, hirsutism, and PCOS—thanks to its anti-androgen effects :contentReference[oaicite:3]{index=3}.
- Advantages of 25 mg dose: Allows precise titration and minimizes endocrine side effects, such as gynecomastia.
- On WHO list: Recognized as one of the world’s essential medicines for its efficacy and safety :contentReference[oaicite:4]{index=4}.
How to use ALDACTONE 25
ALDACTONE 25 should be used under direct medical guidance. It is taken orally, and dosing should be individualized based on the prescribed indication.
- Administration: Swallow tablets with water; it can be taken with or without food at the same time daily :contentReference[oaicite:5]{index=5}.
- Typical dosing:
- Hypertension: 25–100 mg daily, in one or two doses :contentReference[oaicite:6]{index=6}.
- Heart failure: Start 25 mg once daily—may increase to 50 mg based on response :contentReference[oaicite:7]{index=7}.
- Edema: 25 mg daily, titrating up to 100 mg depending on fluid retention :contentReference[oaicite:8]{index=8}.
- Primary hyperaldosteronism: Typically starts at 50 mg, titrated up to 400 mg :contentReference[oaicite:9]{index=9}.
- Acne/hirsutism (off-label): 50–150 mg daily :contentReference[oaicite:10]{index=10}.
- Missed dose: Take as soon as possible unless close to the next dose; do not double dose.
- Monitoring: Regularly evaluate blood pressure, potassium levels, renal function, and signs of dehydration or hypotension :contentReference[oaicite:11]{index=11}.
- Long-term use: Often required for chronic conditions; discontinue gradually under medical supervision.
Mode of Action ALDACTONE 25
Spironolactone works by antagonizing aldosterone effects at the mineralocorticoid receptor and has anti-androgen effects.
- Aldosterone blockade: Inhibits aldosterone on distal renal tubules, increasing sodium and water excretion while conserving potassium :contentReference[oaicite:12]{index=12}.
- Diuretic effect: Promotes moderate diuresis through reduced sodium retention, without causing potassium loss—useful in edema and heart failure.
- Endocrine impact: Exhibits anti‑androgen and pro‑gestational activity, blocking androgen receptors and lowering testosterone—helpful in acne and hirsutism :contentReference[oaicite:13]{index=13}.
- Cardiovascular benefits: Reduces cardiac remodeling and fibrosis, improving outcomes in heart failure :contentReference[oaicite:14]{index=14}.
ALDACTONE 25 Interactions ALDACTONE 25
Spironolactone can interact with several medications and supplements, potentially influencing potassium levels, blood pressure, or drug effects.
- Potassium‑raising drugs: ACE inhibitors, ARBs, eplerenone, potassium supplements, and NSAIDs increase risk of hyperkalemia :contentReference[oaicite:15]{index=15}.
- Lithium: Spironolactone can increase serum lithium—monitor closely for neuro and renal toxicity :contentReference[oaicite:16]{index=16}.
- Digoxin: May elevate digoxin levels—caution required :contentReference[oaicite:17]{index=17}.
- Diuretics: Co-admin with loop/thiazide diuretics may enhance effect, magnifying electrolyte disturbances.
- Cholestyramine: May increase hyperkalemic, acid–base imbalance risk :contentReference[oaicite:18]{index=18}.
- Licorice: Opposes spironolactone’s effects via mineralocorticoid-like activity :contentReference[oaicite:19]{index=19}.
Dosage of ALDACTONE 25
The 25 mg dose is typically the starting point or maintenance level. Adjustments are based on clinical indication:
- Hypertension: 25–100 mg daily; consider titrating in split doses.
- Heart failure: 25 mg once daily—may increase to 50 mg; max often 100 mg unless specified :contentReference[oaicite:20]{index=20}.
- Edema: Start 25 mg daily, titrate up to 100 mg based on fluid status.
- Primary hyperaldosteronism: Often 50–200 mg daily; low doses can be effective.
- Acne/hirsutism (off-label): 50–150 mg daily; 25 mg can be used in mild cases :contentReference[oaicite:21]{index=21}.
- Renal impairment (CrCl <50 mL/min): Reduce to 12.5–25 mg, monitor renal function and potassium closely :contentReference[oaicite:22]{index=22}.
- Elderly: Start with 25 mg daily; cautious titration advised.
Possible side effects of ALDACTONE 25
Spironolactone is generally tolerated at lower doses, though side effects may occur:
- Common: Dizziness, headache, gastrointestinal upset (nausea, cramps, diarrhea), drowsiness, leg cramps :contentReference[oaicite:23]{index=23}.
- Endocrine: Gynecomastia and breast tenderness in men; menstrual irregularities and breast pain in women :contentReference[oaicite:24]{index=24}.
- Electrolyte imbalance: Hyperkalemia (can cause arrhythmia), hyponatremia :contentReference[oaicite:25]{index=25}.
- Renal implications: Risk of worsening kidney function, especially with low blood pressure or other meds :contentReference[oaicite:26]{index=26}.
- Dermatologic: Rash, pruritus, and rare Stevens-Johnson syndrome :contentReference[oaicite:27]{index=27}.
- Hematologic/hepatic: Rare leukopenia, thrombocytopenia, or liver enzyme elevations :contentReference[oaicite:28]{index=28}.
ALDACTONE 25 Contraindications ALDACTONE 25
- Absolute contraindications: Hyperkalemia, anuria, acute renal failure, Addison’s disease, use with eplerenone :contentReference[oaicite:29]{index=29}.
- Relative (caution): Chronic kidney or liver disease, diabetes, dehydration, elderly, pregnancy (possible fetal hormonal effects), breastfeeding (excreted in milk) :contentReference[oaicite:30]{index=30}.
- Drug hypersensitivity: Allergy to spironolactone or tablet excipients.
Storage of ALDACTONE 25
- Temperature: Store at 20–25 °C (68–77 °F); avoid extremes of heat or cold.
- Protection: Keep in original container to prevent moisture degradation.
- Expiry: Do not use expired tablets.
- Safety: Store out of children’s reach; secure lid recommended.
- Disposal: Return unused tablets to a pharmacy take-back program; avoid household trash disposal.
ALDACTONE 25 features an exceptional active ingredient renowned for its potent effects, comprising Spironolactone. This powerful formulation provides a superior solution for addressing diverse health concerns. With 25mg/Tablet concentration and an easily manageable Tablets, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ALDACTONE 25 .
Welcome to Dwaey, specifically on ALDACTONE 25 page.
This medicine contains an important and useful components, as it consists of Spironolactone.
ALDACTONE 25 is available in the market in concentration 25mg/Tablet and in the form of Tablets.
SEARLE PHARMACEUTICALS is the producer of ALDACTONE 25 and it is imported from UK,
The most popular alternatives of ALDACTONE 25 are listed downward .
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Frequently Asked Questions
ALDACTONE 25 should be stored according to the instructions provided by SEARLE PHARMACEUTICALS.
In general, it is recommended to store ALDACTONE 25 in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ALDACTONE 25 may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ALDACTONE 25 for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ALDACTONE 25. Some medications, including
ALDACTONE 25, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ALDACTONE 25, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ALDACTONE 25 without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ALDACTONE 25 if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ALDACTONE 25 during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 25mg/Tablet,
and the specific recommendations of SEARLE PHARMACEUTICALS.
The effects of ALDACTONE 25 on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 25mg/Tablet, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ALDACTONE 25 with or without food may vary depending on the medication
and the recommendations of SEARLE PHARMACEUTICALS. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ALDACTONE 25 in children or elderly individuals may depend on various factors, including
the specific medication, type Tablets, and the recommendations of SEARLE PHARMACEUTICALS. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ALDACTONE 25 in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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