What is ALDACTONE 25
ALDACTONE 25 is an oral medication containing 25 mg of spironolactone, a potassium-sparing diuretic and aldosterone antagonist. It is used to treat various medical conditions related to fluid retention, high blood pressure, and hormonal imbalances.
- Drug Classification: Potassium-sparing diuretic; aldosterone receptor antagonist.
- Mechanism: Blocks aldosterone receptors in the kidneys, promoting sodium and water excretion while conserving potassium.
- Indications:
- Edema associated with heart failure, liver cirrhosis, or nephrotic syndrome
- Essential hypertension
- Primary hyperaldosteronism (diagnosis and treatment)
- Heart failure with reduced ejection fraction (HFrEF)
- Polycystic ovary syndrome (PCOS) and hirsutism (off-label)
- Tablet Strength and Packaging: Each tablet contains 25 mg spironolactone; the 100-count pack is suitable for long-term management of chronic conditions.
- Benefits: Helps manage fluid overload and reduce blood pressure while preserving potassium levels—an advantage over loop or thiazide diuretics.
- Special Considerations: Often used in combination with other antihypertensives or diuretics in resistant cases.
How to use ALDACTONE 25
Proper administration of ALDACTONE 25 is essential to ensure safety and therapeutic success. The dosage depends on the medical indication, patient response, and coexisting health conditions.
- Route of Administration: Oral (by mouth)
- Timing: Can be taken with or without food. Taking it with food may reduce gastrointestinal discomfort.
- Dosage Frequency: Usually once or twice daily depending on the dose.
- Missed Dose: If you miss a dose, take it as soon as you remember. If it's near the next dose, skip the missed one. Never double up doses.
- Monitoring Requirements:
- Serum potassium and sodium
- Renal function tests (e.g., serum creatinine, eGFR)
- Blood pressure
- Long-Term Use Tips:
- Ensure regular follow-up with your healthcare provider.
- Stay hydrated and avoid potassium-rich foods or supplements unless advised.
- Precautions:
- Use caution in the elderly or patients with kidney impairment.
- Do not abruptly discontinue without consulting a physician.
Mode of Action ALDACTONE 25
Spironolactone, the active ingredient in ALDACTONE 25, exerts its pharmacologic effects by antagonizing aldosterone—a hormone that promotes sodium retention and potassium excretion.
- Renal Effects:
- Inhibits aldosterone at the distal renal tubules.
- Promotes excretion of sodium and water.
- Reduces potassium and hydrogen ion excretion—preventing hypokalemia.
- Cardiovascular Benefits:
- Reduces preload and afterload via diuresis.
- Lowers blood pressure in hypertensive patients.
- Prevents cardiac remodeling in heart failure by blocking aldosterone-mediated fibrosis.
- Endocrine Effects:
- Anti-androgenic activity by blocking androgen receptors and inhibiting testosterone synthesis.
- Useful in conditions like PCOS, acne, and hirsutism in women.
- Onset of Action: Diuretic effect begins within a few days; full antihypertensive effect may take 2–4 weeks.
- Half-life: Spironolactone has an approximate half-life of 1.5 hours, but its active metabolites (e.g., canrenone) prolong its effect.
ALDACTONE 25 Interactions ALDACTONE 25
Spironolactone may interact with a wide range of medications and supplements, requiring close monitoring and dose adjustments.
- Drugs Increasing Potassium:
- ACE inhibitors (e.g., enalapril, lisinopril)
- ARBs (e.g., losartan)
- Potassium supplements
- NSAIDs
- Trimethoprim-sulfamethoxazole (may lead to severe hyperkalemia)
- Diuretics:
- Loop and thiazide diuretics may enhance diuretic efficacy but increase risk of electrolyte imbalance.
- Lithium: Risk of lithium toxicity increases due to reduced clearance.
- Digoxin: Levels may increase; monitor for digoxin toxicity symptoms.
- Anticoagulants: Spironolactone may interfere with warfarin metabolism, requiring INR monitoring.
- Alcohol: Enhances the blood pressure-lowering effect and dizziness—limit alcohol intake.
Dosage of ALDACTONE 25
ALDACTONE 25 is used in individualized doses depending on the specific condition. Below is a dosing guide based on standard practices:
- Hypertension: 25–100 mg daily, usually started at 25 mg once daily.
- Edema (CHF, liver cirrhosis, nephrotic syndrome): 25–200 mg/day in divided doses depending on severity.
- Heart Failure (HFrEF): 25 mg daily; may be increased to 50 mg if tolerated.
- Primary Hyperaldosteronism: Diagnostic: 100–400 mg/day; Maintenance: lowest effective dose, typically 50–100 mg.
- Hirsutism/PCOS (off-label): 50–100 mg twice daily.
- Geriatric Dosing: Start low (12.5–25 mg) and adjust based on renal function and potassium levels.
- Renal Impairment: Avoid use in severe renal dysfunction; monitor potassium and creatinine closely.
Possible side effects of ALDACTONE 25
While generally well tolerated at 25 mg, spironolactone may cause side effects that range from mild to serious. Monitoring is important during long-term use.
- Common Side Effects:
- Nausea, vomiting
- Dizziness, headache
- Muscle cramps
- Menstrual irregularities
- Endocrine-Related Effects:
- Gynecomastia in males (dose-dependent, reversible on discontinuation)
- Breast tenderness
- Impotence or libido changes
- Electrolyte Imbalance:
- Hyperkalemia (potentially life-threatening)
- Hyponatremia
- Rare But Serious Reactions:
- Agranulocytosis
- Hepatotoxicity
- Stevens-Johnson syndrome
ALDACTONE 25 Contraindications ALDACTONE 25
ALDACTONE 25 should not be used in specific medical conditions where its pharmacological effects can worsen the patient’s state or pose serious risks.
- Absolute Contraindications:
- Hyperkalemia (serum K+ >5.5 mEq/L)
- Anuria
- Acute renal insufficiency
- Known hypersensitivity to spironolactone
- Relative Contraindications (Use with Caution):
- Chronic kidney disease (especially eGFR <30 mL/min)
- Liver dysfunction
- Pregnancy—risk of feminization of male fetus
- Lactation—excreted in breast milk
- Drug Interactions Worsening Risk: Concurrent use with potassium supplements or ACE inhibitors increases hyperkalemia risk.
Storage of ALDACTONE 25
Proper storage ensures the stability, safety, and effectiveness of the medication throughout its shelf life.
- Temperature: Store at 20°C to 25°C (68°F to 77°F). Brief excursions permitted between 15°C and 30°C.
- Humidity: Store in a dry place away from moisture and humidity. Do not store in bathrooms.
- Light Protection: Keep in original packaging to protect from light exposure.
- Child Safety: Store out of the reach of children and pets. Use child-resistant packaging.
- Disposal: Do not flush down the toilet. Dispose of unused tablets via pharmacy take-back programs or as directed by local regulations.
ALDACTONE 25 features an exceptional active ingredient renowned for its potent effects, comprising Spironolactone. This powerful formulation provides a superior solution for addressing diverse health concerns. With 25mg/Tablet concentration and an easily manageable Tablets, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ALDACTONE 25 .
Welcome to Dwaey, specifically on ALDACTONE 25 page.
This medicine contains an important and useful components, as it consists of Spironolactone.
ALDACTONE 25 is available in the market in concentration 25mg/Tablet and in the form of Tablets.
SEARLE PHARMACEUTICALS is the producer of ALDACTONE 25 and it is imported from UK,
The most popular alternatives of ALDACTONE 25 are listed downward .
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Frequently Asked Questions
ALDACTONE 25 should be stored according to the instructions provided by SEARLE PHARMACEUTICALS.
In general, it is recommended to store ALDACTONE 25 in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ALDACTONE 25 may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ALDACTONE 25 for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ALDACTONE 25. Some medications, including
ALDACTONE 25, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ALDACTONE 25, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ALDACTONE 25 without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ALDACTONE 25 if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ALDACTONE 25 during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 25mg/Tablet,
and the specific recommendations of SEARLE PHARMACEUTICALS.
The effects of ALDACTONE 25 on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 25mg/Tablet, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ALDACTONE 25 with or without food may vary depending on the medication
and the recommendations of SEARLE PHARMACEUTICALS. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ALDACTONE 25 in children or elderly individuals may depend on various factors, including
the specific medication, type Tablets, and the recommendations of SEARLE PHARMACEUTICALS. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ALDACTONE 25 in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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