(BAXTER) GLUCOSE 10% w/v Solution for Infusion

What is (BAXTER) GLUCOSE 10% w/v

BAXTER GLUCOSE 10% w/v is a sterile, non-pyrogenic solution of glucose (dextrose) in water for intravenous infusion. It is primarily used for:

• Providing a source of carbohydrates (calories) when oral intake is not possible or inadequate
• Rehydration in cases of fluid loss or dehydration
• Vehicle for dilution or delivery of other intravenous medications

This formulation is packaged in 250 ml Viaflo plastic bags, available in cartons of 30, and intended exclusively for hospital or clinical use under sterile conditions. Each 100 ml contains 10 grams of glucose anhydrous, offering 400 kcal per liter.

The solution is isotonic to mildly hypertonic and is free from electrolytes, making it suitable for specific clinical situations where electrolyte-free fluid replacement is needed or when combined with electrolyte solutions. BAXTER GLUCOSE 10% w/v is used across various therapeutic areas including surgery, critical care, and internal medicine.

How to use (BAXTER) GLUCOSE 10% w/v

BAXTER GLUCOSE 10% w/v should only be administered under medical supervision in a hospital or clinical setting. The solution is administered intravenously (IV) using aseptic technique through a dedicated IV line.

• Route of administration: Intravenous infusion only
• Preparation: Inspect the solution for clarity and absence of particulate matter before use. Do not use if the solution is discolored or if the container is damaged
• Administration method: Use a sterile infusion set. Connect the bag to an IV line and adjust the flow rate according to the patient's clinical status and fluid needs
• Infusion rate: Must be tailored based on:
  • Patient’s age and weight
  • Fluid and electrolyte balance
  • Glucose metabolism
  • Underlying disease conditions (e.g., diabetes, renal failure)

Infusion must be monitored closely to avoid fluid overload, hyperglycemia, or electrolyte disturbances. This solution should not be administered simultaneously with blood products in the same IV line.

Mode of Action (BAXTER) GLUCOSE 10% w/v

Glucose (dextrose) is a simple monosaccharide that serves as a vital energy source in cellular metabolism. When administered intravenously, BAXTER GLUCOSE 10% w/v functions by:

• Providing metabolic fuel: It serves as an immediate energy substrate for tissues and organs, particularly the brain, red blood cells, and muscles
• Rehydration support: Helps in restoring fluid volume without introducing additional electrolytes, ideal in specific clinical conditions like hypernatremia or hyperosmolar states
• Glycogen replenishment: Supports hepatic glycogen stores, particularly important in patients who are fasting or under metabolic stress
• Protein sparing: Prevents protein breakdown by supplying calories, reducing catabolism in critically ill patients

Once in circulation, glucose is taken up by cells via insulin-mediated transport and metabolized through glycolysis, Krebs cycle, and oxidative phosphorylation to produce ATP. Any excess glucose is stored as glycogen or converted into fat.

(BAXTER) GLUCOSE 10% w/v Interactions (BAXTER) GLUCOSE 10% w/v

While BAXTER GLUCOSE 10% w/v is primarily a supportive fluid, it can interact with medications or medical conditions that influence glucose metabolism or fluid balance. Clinicians must be vigilant when administering it with certain drugs:

• Insulin: Enhances cellular uptake of glucose; may require dose adjustment to prevent hypoglycemia
• Corticosteroids and thiazide diuretics: May increase blood glucose levels by reducing insulin sensitivity
• Diuretics (loop/thiazide): Can influence hydration status; co-administration requires electrolyte monitoring
• Other IV solutions: Compatibility should be verified before co-infusion. Incompatible solutions can cause precipitation or reduce efficacy

Monitor serum glucose and electrolytes during administration, especially in patients on antidiabetic agents or with renal impairment. This solution should not be mixed with blood products due to the risk of hemolysis or clotting.

Dosage of (BAXTER) GLUCOSE 10% w/v

Dosage should be individualized based on the patient's age, weight, clinical condition, fluid, and caloric needs. The standard dosage guidelines include:

• Adults: 500–3000 ml per 24 hours, depending on hydration and caloric requirements
• Children and infants: 10–20 ml/kg/hr or as prescribed based on age and weight
• Maximum rate: Should not exceed the patient’s glucose oxidation capacity (generally 4–5 mg/kg/min in adults)
• Monitoring: Regular checks of blood glucose levels, serum electrolytes, and fluid balance are necessary

In diabetic or critically ill patients, a more cautious approach is necessary to avoid hyperglycemia or glucose-induced osmotic diuresis. A slow infusion rate with frequent monitoring is advisable.

Possible side effects of (BAXTER) GLUCOSE 10% w/v

p>Although generally well-tolerated when administered appropriately, BAXTER GLUCOSE 10% w/v can cause side effects, particularly in high doses or prolonged infusions:

• Common Side Effects:
  • Local irritation or pain at infusion site
  • Mild hyperglycemia
• Metabolic Effects:
  • Hyperglycemia, especially in diabetic patients
  • Electrolyte imbalance (e.g., hyponatremia, hypokalemia)
  • Fluid overload or edema, especially in renal or cardiac-compromised patients
• Rare but Serious Side Effects:
  • Lactic acidosis in cases of severe hepatic impairment
  • Thrombophlebitis at the infusion site

Monitoring during infusion is crucial. Adverse reactions should prompt adjustment or discontinuation of the infusion.

(BAXTER) GLUCOSE 10% w/v Contraindications (BAXTER) GLUCOSE 10% w/v

BAXTER GLUCOSE 10% w/v is contraindicated in several medical situations, particularly where glucose administration may worsen underlying conditions:

• Uncontrolled diabetes mellitus – Risk of significant hyperglycemia
• Hyperosmolar states – Can exacerbate dehydration and electrolyte shifts
• Severe hypokalemia – Risk of cardiac arrhythmias without concurrent potassium supplementation
• Intracranial or intraspinal hemorrhage – Increased risk of cerebral edema with hypotonic solutions
• Known allergy to corn or corn products – As dextrose is typically derived from corn

Administration should always be guided by clinical parameters, lab investigations, and under medical supervision. Caution is required in neonates, the elderly, and patients with renal or hepatic insufficiency.

Storage of (BAXTER) GLUCOSE 10% w/v

Proper storage of BAXTER GLUCOSE 10% w/v is essential to maintain sterility and efficacy. The following storage guidelines should be strictly followed:

• Temperature: Store at 15°C to 25°C (59°F to 77°F). Avoid freezing
• Light protection: Keep away from direct sunlight or fluorescent lighting
• Do not use if:
  • The solution is discolored or contains visible particles
  • The container is leaking or compromised
• After opening: Use immediately. Discard any unused portion to prevent contamination
• Shelf life: Refer to packaging label for expiration date

Store in a controlled environment, away from chemicals or incompatible products. Follow local guidelines for disposal of unused or expired solutions.