SINEMET CR 100/25 price in UAE

Overview

Welcome to Dwaey, specifically on SINEMET CR 100/25 Tablets page.
This medicine contains an important and useful components, as it consists of Co-Careldopa (Levodopa, Carbidopa).
SINEMET CR 100/25 is available in the market in concentration 100mg, 25mg/Tablet and in the form of Tablets.

MERCK SHARP & DOHME B.V. is the producer of SINEMET CR 100/25 and it is imported from NETHERLANDS, The most popular alternatives of SINEMET CR 100/25 are listed downward .

Mode Of Action

Levodopa is the metabolic precurosor of dopamine, it crosses the blood-brain barrier and is converted to dopamine in the brain. Carbidopa increases the amount of levodopa that is transported into the CNS by inhibiting the decarboxylation of peripheral levodopa.

Indication

Parkinson's disease.

Precaution

Heart disease, liver disease, dementia, psychosis, pregnancy, elderly, heart disease. Regular monitoring of renal and hepatic function is reccomended. Lactation: Drug inhibits lactation; use with caution

Side Effects

Edema
Agitation
anxiety
ataxia
bruxism
confusion
daytime somnolence decreased attention span
dyskinesia
dystonia
euphoria
insomnia
fainting
fatigue
increased trembling of hands
insouciance
malaise
memory loss
nightmares
nervousness
restlessness
trismus
vivid dreams
Alopecia
hot flushes
increased &/or dark perspiration
skin eruptions
Abdominal pain & discomfort
burning feeling in tongue
constipation
diarrhea
dysgeusia
dry mouth
dysphagia
hiccups
meteorism
sialorrhea
nausea
weight loss
Muscular spasms
muscular cramp
Hematuria
dark urine
incontinence
priapism
urine retention
Blurred vision
diplopia
dilated pupil
oculogyric problems. Potentially Fatal: Severe postural hypotension in elderly.

Contra indication

Lactation, narrow angle glaucoma, melanoma, psychosis, severely decompensated endocrine.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Interaction

Pyridoxine reverses effects of levodopa. Type-B MAOIs have synergistic effect. Effect reduced by phenothiazines, haloperidol, reserpine, pyridoxine, diazepam, oxazepam, chlordiazepoxide, phenobarbitone. Effects of levodopa enhanced by carbidopa, amantadine, anticholinergics, amphetamine. Effects of sympathomimetic agents enhanced. Potentially Fatal: Enhances hypotensive effects of bethanidine, bretylium, guanethidine. Hypertensive crises with furazolidone or MAO inhibitors.