AMPHOTERICIN B DUMEX 50mg Price

Overview

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This medicine contains an important and useful components, as it consists of
Amphotericin Bis available in the market in concentration

Name

Amphotericin B

Precaution

Renal and hepatic impairment; pregnancy; monitor renal and liver function changes. Lactation: Excretion in milk is unknown; due to the potential for serious adverse reactions in breast-fed infants, a decision should be made whether to discontinue nursing or whether to discontinue the drug, taking into account the importance of the drug to the mother

Indication

Endocarditis, Systemic fungal infections, Visceral leishmaniasis, Primary amoebic meningoencephalitis, Thrush, Cryptococcal meningitis, Candidiasis, Aspergillosis, Candidal cystitis

Contra indication

Hypersensitivity; lactation; do not give to patients receiving antineoplastics.

Side Effect

>10% Anorexia,Chills,Diarrhea,Fever,Headache,Hypokalemia,Hypomagnesemia,Hypotension,Malaise,Nausea,Pain (generalized),Pain at injection site,Renal function abnormalities,Tachypnea,Vomiting 1-10% Arachnoiditis,Delerium,Flushing,Hypertension,Leukocytosis,Lumbar nerve pain,Paresthesia,Urinary retention <1% Agranulocytosis,Anuria,Bone marrow suppression,Cardiac arrest,Coagulation defects,Convulsions,Dyspnea,Hearing loss,Leukopenia,Maculopapular rash,Renal failure,Thrombocytopenia,Vision changes Potentially Fatal: Anaphylactic reaction; leucoencephalopathy. Overdosage can result in cardio-respiratory arrest.

Pregnancy Category ID

2

Mode of Action

Amphotericin B is a polyene antifungal antibiotic which alters cell membrane permeability by binding to ergosterol, thus causing leakage of cell components and subsequent cell death. It is active against Absidia spp, Aspergillus spp, Basidiobolus spp, B. dermatitidis, Candida spp, C. immitis, Conidobolus spp, C. neoformans, H. capsulatum, Mucor spp, P. brasiliensis, Rhizopus spp, Rodotorula spp. and S. schenckii.

Interaction

Increased toxicity with flucytosine. Drug induced renal toxicity enhanced in presence of other nephrotoxic medications. Antagonises effects of azole antifungals. Potentially Fatal: Potentiates K loss by corticosteroids. Avoid diuretics. Enhances digitalis toxicity and neuromuscular blocker effects.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration