SEPTILIN Price

Overview

Welcome to Dwaey, specifically on SEPTILIN page.
This medicine contains an important and useful components, as it consists of
Balsamodendron mukul (Indian Bdellium tree powder, purified), Conch shell calx (Shankh bhasma powder), Emblica officinalis (Indian Gooseberry ext.), Glycyrrhiza glabra (Licorice ext.), Moharasnadi quath, Moringa pterygosperma (Horse raddish tree ext.), Ruis available in the market in concentration

Name

Misoprostol

Precaution

Before starting **Misoprostol**, it is essential to consult with a healthcare provider. Key precautions include: - **Pregnancy**: **Misoprostol** is contraindicated during pregnancy for **gastric ulcer treatment** but may be prescribed for **medical abortion** under medical supervision. The drug can cause **uterine contractions**, leading to miscarriage or premature labor if used incorrectly during pregnancy. Women must confirm they are not pregnant before using **Misoprostol** for any non-abortion indications. - **Cardiovascular Disease**: **Misoprostol** may cause **cardiovascular side effects**, such as increased heart rate or blood pressure changes. It should be used cautiously in individuals with **heart disease** or **hypertension**. - **Renal Impairment**: Patients with impaired kidney function should use **Misoprostol** cautiously, as the drug is excreted through the kidneys. Dosage adjustments may be required in individuals with **renal dysfunction**. - **Gastrointestinal Disorders**: **Misoprostol** can cause **diarrhea** and may exacerbate underlying gastrointestinal issues. Patients with a history of chronic **inflammatory bowel disease (IBD)** or **irritable bowel syndrome (IBS)** should use the drug with caution. - **Lactation**: **Misoprostol** is excreted in breast milk in small amounts. While it is generally considered safe for breastfeeding mothers, it is advisable to consult a healthcare provider before use to evaluate risks.

Indication

**Misoprostol** has several indications, primarily in the **gastrointestinal** and **gynecological** fields: - **Prevention of Gastric Ulcers**: **Misoprostol** is used to prevent **NSAID-induced gastric ulcers** in patients who require chronic **NSAID** therapy. It works by reducing stomach acid secretion and increasing the production of protective mucus in the stomach lining. - **Medical Abortion**: When used in combination with **mifepristone**, **Misoprostol** is prescribed for the medical abortion of early pregnancies (up to 10 weeks of gestation). It causes **uterine contractions**, expelling the fetus. - **Induction of Labor**: In some cases, **Misoprostol** is used off-label to induce labor in pregnant women who are at or near term. - **Postpartum Hemorrhage**: **Misoprostol** is used to prevent or treat **postpartum hemorrhage** (excessive bleeding after childbirth) by promoting **uterine contractions** to reduce blood loss. - **Cervical Ripening**: **Misoprostol** may be used off-label for **cervical ripening** before labor induction.

Contra indication

**Misoprostol** should not be used in the following situations: - **Pregnancy (for ulcer prevention)**: **Misoprostol** should not be used during pregnancy unless it is being used for **abortion** or **induction of labor**, as it can cause **uterine contractions**, leading to miscarriage, preterm labor, or birth defects. - **Hypersensitivity**: **Misoprostol** is contraindicated in individuals with known hypersensitivity or allergic reactions to **Misoprostol** or any of its components. Symptoms may include rash, swelling, or difficulty breathing. - **Breastfeeding (for abortion)**: Due to its potential for causing contractions and **uterine bleeding**, **Misoprostol** should not be used during breastfeeding unless absolutely necessary, and only under strict medical supervision. - **Active Gastrointestinal Disease**: Individuals with active **inflammatory bowel disease**, such as **Crohn's disease** or **ulcerative colitis**, should avoid using **Misoprostol**, as it can cause significant gastrointestinal distress, including diarrhea.

Side Effect

Common and severe side effects of **Misoprostol** should be monitored: - **Common Side Effects**: - **Diarrhea** is a frequent side effect of **Misoprostol**, particularly when used for ulcer prevention or induction of labor. It can be severe in some cases. - **Abdominal Pain** or **cramping** may occur due to the contraction of the uterus or gastrointestinal effects. - **Nausea** or **vomiting** can occur, especially when used for abortion or labor induction. - **Fever** may occur as part of the uterine contractions and the overall process of pregnancy termination or labor induction. - **Headache** or **dizziness** may be reported by some users. - **Severe Side Effects**: - **Uterine Rupture**: When used for labor induction, there is a risk of **uterine rupture**, particularly if used in conjunction with other **oxytocic agents**. - **Excessive Bleeding**: **Misoprostol** may cause **heavy bleeding**, particularly when used for medical abortion or postpartum hemorrhage. Excessive bleeding can lead to **hypovolemic shock** and require medical intervention. - **Severe Allergic Reactions**: **Anaphylaxis**, although rare, can occur, and symptoms may include swelling of the face or throat, difficulty breathing, or a rash. Immediate medical attention is needed. - **Hyperstimulation of the Uterus**: This can lead to **fetal distress**, **uterine rupture**, or **preterm labor**. It is critical to monitor the patient closely during labor induction.

Pregnancy Category ID

5

Mode of Action

**Misoprostol** acts through its effects on the **prostaglandin receptors**: - **Inhibition of Gastric Acid Secretion**: In the gastrointestinal tract, **Misoprostol** is a synthetic prostaglandin E1 analog that inhibits the production of stomach acid by blocking the action of **prostaglandin receptors**. This promotes the secretion of **bicarbonate** and **mucus**, which protect the stomach lining and prevent ulcers. - **Uterine Contraction**: In obstetrics, **Misoprostol** stimulates **uterine contractions** by activating **prostaglandin receptors** on the uterine smooth muscle. This action is utilized for inducing labor, medical abortion, and controlling postpartum bleeding.

Interaction

Several drug interactions may affect the efficacy or safety of **Misoprostol**: - **Nonsteroidal Anti-inflammatory Drugs (NSAIDs)**: **Misoprostol** is often used in conjunction with **NSAIDs** to prevent gastric ulcers. When used together, it reduces the risk of **NSAID-induced ulcers**. - **Antacids and Proton Pump Inhibitors (PPIs)**: The effectiveness of **Misoprostol** can be decreased when combined with **antacids** or **proton pump inhibitors**, which reduce stomach acid and interfere with the drug's mechanism of action. - **Oxytocics**: **Misoprostol** used for **inducing labor** should not be combined with other **oxytocic agents**, as it may cause excessive uterine contractions and lead to **uterine rupture** or fetal distress. - **Anticoagulants**: **Misoprostol** may increase the risk of **bleeding** if combined with **anticoagulant medications** (e.g., **warfarin**, **heparin**). Caution is required, particularly when using the drug for **postpartum hemorrhage**.

Pregnancy Category Note

Information not available

Adult Dose

The typical **adult dose** of **Misoprostol** varies based on the indication: - **Prevention of Gastric Ulcers**: The usual dose for ulcer prevention is **200 mcg** taken four times a day with food. The maximum dose is **800 mcg/day**. - **Medical Abortion**: For early medical abortion, **Misoprostol** is usually taken as **800 mcg** (administered buccally or sublingually) 24 to 48 hours after **Mifepristone**. - **Induction of Labor**: The recommended dose for labor induction is typically **25 mcg** administered every 4-6 hours until adequate contractions begin or labor progresses. The maximum dose is individualized based on the specific clinical scenario. - **Postpartum Hemorrhage**: For controlling postpartum bleeding, **Misoprostol** is usually given in **800 mcg** as an oral or rectal dose.

Child Dose

**Misoprostol** is not generally recommended for use in pediatric patients unless under strict medical supervision. It is used in certain pediatric cases for **induction of labor** in **stillbirth** or **neonatal death**, but these applications are highly specific and should only be determined by a pediatrician or obstetrician with expertise in the use of **Misoprostol** in this population. As always, patients should consult their healthcare provider before starting **Misoprostol**, as its use can have significant effects depending on the medical condition being treated. Proper supervision and monitoring are essential to ensure safety and effectiveness.

Renal Dose

In patients with **renal impairment**, **Misoprostol** should be used with caution, as the drug is excreted through the kidneys. Dose adjustments may be required based on the degree of renal dysfunction, particularly for **chronic kidney disease**. Close monitoring of renal function is advised when using **Misoprostol** in such patients.

Administration

Information not available