RYTMONORM 300mg Price

Overview

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This medicine contains an important and useful components, as it consists of Propafenone HCl.
RYTMONORM 300mg is available in the market in concentration 300mg/Tablet and in the form of Tablets.

ABBOTT GmbH & CO. KG is the producer of RYTMONORM 300mg and it is imported from GERMANY, The most popular alternatives of RYTMONORM 300mg are listed downward .

Mode Of Action

Propafenone is a class 1C antiarrhythmic drug with local anaesthetic effects, and a direct stabilising action on myocardial membranes. The electrophysiological effect manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity.

Indication

• Supraventricular and ventricular arrhythmias
• Atrial Fibrillation/Flutter

Precaution

Severe pulmonary obstructive diseases, CHF, cardiac pacemaker, impaired renal/hepatic function, pregnancy, lactation, elderly. Correct electrolyte disturbances before starting treatment. May worsen heart failure in patients with preexisting organic heart disease. May worsen or cause new severe ventricular arrhythmias e.g. ventricular tachycardia or fibrillation. May aggravate electrically induced ventricular tachycardia in some patients. Lactation: Crosses into breast milk; discontinue drug or do not nurse

Side Effects

• >10% Unusual taste (7-23%)
• Dizziness/lightheadedness (7-15%)
• N/V (3-11%) 1-10% Constipation (4-8%)
• Headache (2-6%)
• Intraventricular conduction delay (4%)
• Fatigue (6%)
• Blurred vision (3%)
• Weakness (3%)
• Dyspnea (2%)
• Wild complex tachycardia (2%)
• Bradycardia (2%)
• Palpitations (2%)
• Tremor (2%)
• Anorexia (2%)
• Diarrhea (2%)
• Ataxia (2%)
• 1°AV block (2-5%)
• Angina (5%)
• Palpitations (3%)
• CHF (2-3% )
• Chest pain (2%)
• Bradyarrhythmia (2%)
• AF (1%)
• Bundle branch block (1%)
• 2nd degree AV block (1%)
• Hypotension (1%)
• Sinus arrest (1%) Frequency Not Defined Lethargy
• Rash
• Dyspepsia
• Dry mouth
• Agranulocytosis
• Hepatotoxicity (rare)
• Systemic lupus erythematosus (rare)
• Bronchospasm (rare) Potentially Fatal: SA/AV or intraventricular blocks. Severe hypotension
• especially in elderly.

Contra indication

Uncontrolled heart failure, marked hypotension, severe bradycardia and heart block, conduction abnormalities, cardiogenic shock, myasthenia gravis.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks