RUXIENCE 500 mg Price

Overview

Welcome to Dwaey, specifically on RUXIENCE 500 mg Concentrate for solution for infusion page.
This medicine contains an important and useful components, as it consists of Rituximab.
RUXIENCE 500 mg is available in the market in concentration 500 mg/50 ml and in the form of Concentrate for solution for infusion.

PFIZER EUROPE MA EEIG is the producer of RUXIENCE 500 mg and it is imported from BELGIUM, The most popular alternatives of RUXIENCE 500 mg are listed downward .

Mode Of Action

Rituximab is a chimeric monoclonal antibody to CD20 antigen which regulates cell cycle initiation. It binds to the antigen on the cell surface, activating complement-dependent B-cell cytotoxicity; and to human Fc receptors, mediating cell killing through an antibody-dependent cellular toxicity.

Indication

• Non-Hodgkin's lymphoma; follicular lymphoma

Precaution

Extensive tumor burden, pulmonary tumor infiltration or pulmonary insufficiency; history of cardiac disease; effective contraception during and up to 12 mth after treatment; pregnancy. Monitor CBC and platelet counts regularly. Premedication with analgesics, antihistamines and corticosteroids may be recommended. Monitor for signs of active infection or hepatitis in hepatitis B carriers. Discontinue treatment if viral hepatitis develops. Lactation: not known if excreted in breast milk, do not nurse

Side Effects

• >10% NHL Angioedema (11%)
• hypotension (10%)
• Asthenia (26%)
• chills (33%)
• dizziness (10%)
• fever (53%)
• headache (19%) Pruritus (14%)
• rash (15%)
• Abdominal pain (14%)
• diarrhea (10%)
• nausea (23%)
• vomiting (10%) Leukopenia (14%)
• lymphopenia (48%)
• neutropenia (14%)
• thrombocytopenia (12%)
• Back pain (10%)
• myalgia (10%) Cough (13%)
• rhinitis (12%)
• Infection (31%)
• night sweats (15%) 1-10% NHL Edema
• Flushing
• Hypertension
• Anxiety
• Anemia
• Elevated LDH
• Hyperglycemia
• Bronchospasm
• dyspnea
• sinusitis
• throat irritation
• urticaria
• RA (Rituximab+Methotrexate vs Methotrexate Alone) Hypertension
• Anxiety
• asthenia
• chills
• migraine
• paresthesia
• pyrexia
• Pruritus
• urticaria
• Dyspepsia
• nausea
• upper abd pain
• Hypercholesterolemia
• Arthralgia
• Rhinitis
• throat irritation
• URI Frequency Not Defined Tumor lysis syndrome
• Lymphoid malignancies
• Hypogammaglobulinemia Potentially Fatal: Pulmonary or cardiac toxicity during infusion; severe mucocutaneous reactions; severe cytokine release syndrome associated with tumor lysis syndrome. Toxic epidermal necrolysis.

Contra indication

Lactation. Type I hypersensitivity or anaphylactic reactions to murine proteins or component of the formulation.

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks