ROZLYTREK 200 mg Price

Overview

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This medicine contains an important and useful components, as it consists of
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Name

Bisacodyl

Precaution

Before using bisacodyl, it is essential to consider the individual's medical history, especially for those with gastrointestinal (GI) disorders, including bowel obstructions, inflammatory bowel disease (IBD), or chronic constipation. Bisacodyl should not be used in patients with a history of appendicitis, abdominal pain of unknown cause, or rectal bleeding, as it can worsen these conditions. Special caution is necessary for pregnant and breastfeeding women, as bisacodyl should be used during pregnancy only if clearly needed, as its safety in pregnancy is not fully established. Bisacodyl may also cause electrolyte imbalances or dehydration if used excessively, so patients should be monitored for fluid balance and electrolyte levels, particularly in the elderly or those with underlying kidney or heart conditions. Additionally, misuse or prolonged use of bisacodyl can lead to dependency, where the bowel becomes reliant on the stimulant for regular movement, leading to chronic constipation and further digestive issues. Therefore, its use should be limited to short-term relief and not for extended periods unless under medical supervision.

Indication

Bisacodyl is primarily indicated for the relief of constipation. It is a stimulant laxative that works by stimulating bowel movements, primarily through its action on the colon, promoting peristalsis. Bisacodyl is commonly used to treat acute constipation, especially in individuals who have not responded to dietary changes, increased fiber, or stool softeners. It is also used as part of bowel preparation before surgical procedures or diagnostic tests like colonoscopies, to clear the bowel. In this context, bisacodyl is often used in combination with other agents for a more effective cleanse. Off-label, bisacodyl may be used in situations where a patient needs short-term bowel stimulation for reasons such as opioid-induced constipation or as an adjunct therapy in chronic constipation, but this should be closely monitored by healthcare professionals. The use of bisacodyl is typically short-term, and long-term use for chronic constipation is not recommended due to the risk of dependence and worsening symptoms.

Contra indication

There are several conditions in which bisacodyl should not be used due to potential risks. Contraindications include bowel obstruction, appendicitis, or acute abdominal conditions such as abdominal pain, nausea, or vomiting of unknown cause. In these cases, stimulant laxatives like bisacodyl could exacerbate the underlying condition. Patients with severe dehydration or electrolyte imbalances should also avoid bisacodyl, as its use may worsen dehydration or contribute to electrolyte disturbances, leading to more severe health issues like arrhythmias or kidney problems. Bisacodyl is not recommended for use in individuals with a history of rectal bleeding or undiagnosed blood in stools, as it may mask these serious symptoms. Children under 6 years old should not use bisacodyl unless directed by a healthcare provider, as younger children are more susceptible to electrolyte imbalances. Additionally, bisacodyl should be avoided during pregnancy unless absolutely necessary, as its safety during pregnancy is not well established.

Side Effect

Bisacodyl is generally well tolerated, but like all medications, it can cause side effects, especially if used improperly. The most common side effects include abdominal cramps, discomfort, and diarrhea. These effects are typically mild and transient but may be more pronounced with excessive use. Prolonged use can lead to electrolyte imbalances, dehydration, or dependence, where the bowel becomes reliant on the stimulant for regular function. Other potential side effects include rectal irritation or burning, especially if the medication is used in suppository form. More severe side effects, though rare, include blood in the stool, severe abdominal pain, or signs of dehydration such as dry mouth, dizziness, or fainting. If any of these more serious symptoms occur, medical attention should be sought immediately. To minimize side effects, bisacodyl should be used only for short periods and in accordance with the recommended dosage. In cases of chronic constipation, a healthcare provider may suggest alternative treatments that are safer for long-term use.

Pregnancy Category ID

3

Mode of Action

Bisacodyl is a stimulant laxative that works by directly stimulating the smooth muscle in the walls of the colon. It induces peristalsis, which is the wave-like contraction of the muscle that propels stool through the intestines. Bisacodyl also increases water secretion into the colon, which helps soften the stool and makes it easier to pass. The exact mechanism involves the activation of the enteric nervous system, which stimulates the release of prostaglandins, compounds that enhance bowel motility. Bisacodyl’s effect is localized to the colon, where it promotes bowel movements. The drug is usually taken orally, but it can also be administered as a suppository, where it acts more rapidly by directly stimulating the rectum and sigmoid colon. The effect of bisacodyl typically occurs within 6 to 12 hours when taken orally, or within 15 to 60 minutes when used as a suppository. This action helps relieve constipation by providing fast and effective relief.

Interaction

Bisacodyl can interact with other medications, potentially affecting its efficacy or leading to harmful side effects. For instance, antacids or milk can alter the absorption of bisacodyl if taken simultaneously. These substances may neutralize the laxative effect, or in some cases, lead to gastrointestinal irritation if bisacodyl is taken too soon after an antacid or milk. Additionally, bisacodyl may interact with diuretics, corticosteroids, and other medications that alter electrolyte balance, potentially increasing the risk of dehydration or electrolyte disturbances. Other medications that affect the gut, such as opioids (which cause constipation), may interact with bisacodyl by altering bowel function. Patients using bisacodyl should avoid taking other laxatives concurrently, as this can lead to an overuse of laxatives, resulting in dehydration, severe electrolyte imbalances, and dependency. Alcohol and high-fat meals can also delay the onset of bisacodyl’s action. It is important for patients to inform their healthcare provider about all other medications and supplements they are taking to minimize potential drug interactions.

Pregnancy Category Note

Information not available

Adult Dose

For adults, the standard oral dose of bisacodyl is typically 5 to 15 mg once daily, preferably taken at bedtime. The dosage can vary based on individual needs, but it is essential to follow the recommended dose to avoid overuse, which can lead to electrolyte imbalances or dependence. If bisacodyl is being used in suppository form, the usual dose is 10 mg, inserted into the rectum once a day. The effects of the suppository are usually faster, occurring within 15 to 60 minutes. In the case of bowel preparation before surgery or colonoscopy, the dose may be higher, often given in combination with other cleansing agents. If constipation persists after the recommended use, the patient should consult a healthcare provider rather than increasing the dose. Long-term use of bisacodyl for chronic constipation is generally not recommended, as it can cause the bowel to become dependent on the stimulant for function.

Child Dose

For children aged 6 to 12 years, the recommended oral dose of bisacodyl is typically 5 to 10 mg once daily. For children under 6 years, bisacodyl is generally not recommended unless directed by a physician. In the case of suppositories, the usual dose for children is 5 mg, though it is important that the healthcare provider specifies the appropriate dosage based on the child’s age and weight. Pediatric patients require careful monitoring to ensure that bisacodyl is not overused, as misuse can lead to dehydration or electrolyte disturbances. Additionally, prolonged use of bisacodyl in children can lead to dependency, making it important to follow a healthcare provider’s recommendations closely. Parents and caregivers should also be aware of the signs of overuse, such as persistent abdominal cramps, diarrhea, or excessive thirst, and should contact a healthcare provider if these occur.

Renal Dose

In patients with renal impairment, bisacodyl should be used with caution. Renal disease does not significantly affect the pharmacokinetics of bisacodyl, as it is primarily metabolized in the gastrointestinal tract. However, renal impairment may increase the risk of electrolyte disturbances, particularly if bisacodyl is used excessively. Patients with kidney problems may be more prone to dehydration or imbalances in electrolytes like potassium or sodium, which bisacodyl can exacerbate. It is recommended that renal function be closely monitored in these patients, especially if bisacodyl is used for extended periods or in high doses. Dosage adjustments are typically not required, but caution should be exercised, and the use of bisacodyl should be limited to short-term relief unless otherwise advised by a healthcare provider.

Administration

Information not available