RENALKA Price

Overview

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This medicine contains an important and useful components, as it consists of
Citric acid anhydrous, Sodium bicarbonate anhydrous, Sodium citrate, Tartaric acidis available in the market in concentration

Name

Calcifedio

Precaution

Before starting **Calcifediol** (Calcifedio), it is essential to consult with a healthcare provider, particularly if you have any of the following conditions: - **Hypercalcemia**: **Calcifediol** can increase calcium levels in the blood. Patients with **hypercalcemia** (elevated blood calcium levels) should not use **Calcifediol** unless under strict medical supervision. - **Renal Impairment**: Those with impaired kidney function, particularly **chronic kidney disease**, may require close monitoring. **Calcifediol** is metabolized in the liver and activated to its active form in the kidneys, so kidney function affects its efficacy and safety. - **Vitamin D Toxicity**: Since **Calcifediol** is a precursor of **active vitamin D**, overuse or excessive dosing could lead to **vitamin D toxicity**, with symptoms such as **nausea**, **vomiting**, **weakness**, and **confusion**. - **Calcium Supplementation**: If you're taking calcium supplements, your healthcare provider may need to adjust your **Calcifediol** dosage, as excessive calcium intake can cause hypercalcemia. - **Pregnancy and Breastfeeding**: **Calcifediol** should be used cautiously in pregnant or breastfeeding women. Always discuss the risks and benefits with a healthcare provider before use. - **Heart Disease**: People with heart disease, especially those at risk for **kidney stones**, should be closely monitored during treatment.

Indication

**Calcifediol** is primarily used in the treatment of **vitamin D deficiency** and related conditions. Some key indications include: - **Vitamin D Deficiency**: It is prescribed to treat or prevent **vitamin D deficiency** in individuals with conditions such as **osteomalacia**, **rickets**, and **osteoporosis**. - **Chronic Kidney Disease**: In patients with **chronic kidney disease (CKD)**, **Calcifediol** helps manage vitamin D deficiency, which is common in these individuals due to impaired kidney function. - **Bone Health**: **Calcifediol** is often used in the management of **bone diseases** like **osteopenia** and **osteoporosis**, as it plays a crucial role in calcium absorption and bone mineralization. - **Hypoparathyroidism**: It is sometimes prescribed to treat **hypoparathyroidism**, a condition where the body doesn’t produce enough parathyroid hormone, affecting calcium and phosphate regulation.

Contra indication

**Calcifediol** should not be used in certain situations or conditions, such as: - **Hypercalcemia**: Patients with high blood calcium levels should avoid **Calcifediol** as it may exacerbate the condition. - **Hypervitaminosis D**: Individuals with excessive levels of **vitamin D** or **vitamin D toxicity** should not take **Calcifediol**. - **Severe Renal Impairment**: **Calcifediol** may need to be avoided in cases of **severe renal dysfunction** where the kidneys are unable to activate vitamin D properly. - **Calcium-Phosphate Imbalance**: Those with conditions leading to **calcium-phosphate imbalances** or **kidney stones** should not use **Calcifediol** without close monitoring.

Side Effect

Although **Calcifediol** is generally well tolerated, some side effects may occur: - **Hypercalcemia**: The most significant side effect of **Calcifediol** is **high calcium levels** in the blood. Symptoms include **nausea**, **vomiting**, **weakness**, **bone pain**, **confusion**, and **kidney stones**. - **Headache**: Some patients may experience mild to moderate headaches as a side effect. - **Gastrointestinal Issues**: **Constipation**, **diarrhea**, and **stomach pain** may occur in some individuals. - **Fatigue**: Feeling tired or lethargic is another potential side effect. - **Skin Rash**: Rarely, skin reactions such as **rashes** or **itching** can occur. - **Hyperphosphatemia**: Excess phosphate levels can occur when combined with **Calcifediol** in patients with kidney problems. - **Kidney Stones**: High calcium levels from **Calcifediol** can lead to the formation of **kidney stones** in predisposed individuals. Patients should seek medical attention if they experience severe side effects like **chest pain**, **irregular heartbeat**, or **severe abdominal pain**.

Pregnancy Category ID

Information not available

Mode of Action

**Calcifediol** is a **prodrug** of **calcitriol** (the active form of **vitamin D**). Once administered, **Calcifediol** is metabolized in the liver to **calcitriol**, which then acts on the **intestines**, **kidneys**, and **bones** to regulate calcium and phosphate levels. The primary actions of **calcitriol** include: - **Increased Calcium Absorption**: It enhances the absorption of **calcium** from the intestines. - **Bone Health**: It regulates the mineralization of bones, helping to prevent conditions like **osteomalacia** or **rickets**. - **Kidney Function**: In the kidneys, it promotes calcium reabsorption and phosphate excretion. - **Parathyroid Hormone Regulation**: It also helps regulate the secretion of **parathyroid hormone (PTH)**, which is involved in calcium balance.

Interaction

Several drug interactions can affect **Calcifediol**'s efficacy or safety: - **Anticonvulsants**: Drugs like **phenytoin**, **carbamazepine**, and **phenobarbital** can increase the breakdown of **Calcifediol**, reducing its effectiveness. - **Glucocorticoids**: Corticosteroids, including **prednisone**, may interfere with calcium metabolism, affecting the absorption of **Calcifediol**. - **Calcium Supplements**: **Calcium-based** supplements and certain antacids can increase the risk of **hypercalcemia** when taken with **Calcifediol**. - **Thiazide Diuretics**: These medications can increase calcium levels in the blood, and when combined with **Calcifediol**, they may raise the risk of **hypercalcemia**. - **Magnesium and Aluminum Antacids**: **Antacids** containing **magnesium** or **aluminum** may interfere with **Calcifediol**'s absorption. - **Digoxin**: **Digoxin**, a medication used for heart conditions, may increase the risk of **arrhythmias** when combined with **Calcifediol** due to elevated calcium levels.

Pregnancy Category Note

Information not available

Adult Dose

The typical adult dose of **Calcifediol** for **vitamin D deficiency** or related conditions is: - **1-2 mcg** daily, depending on the severity of the deficiency or the specific condition being treated. - The dose can be adjusted based on laboratory findings of **serum calcium** and **phosphate** levels. - **For osteoporosis** or **chronic kidney disease**, higher doses may be required, with a typical dose range of **1-2 mcg** daily or as directed by a healthcare provider. Always consult with a healthcare provider for the appropriate dose and treatment plan based on individual needs and medical history.

Child Dose

The use of **Calcifediol** in children is typically reserved for specific conditions, such as **vitamin D deficiency** or **hypoparathyroidism**. Pediatric dosing should be determined by a healthcare provider based on the child’s weight, age, and medical condition. **Calcifediol** is not commonly used in children unless prescribed for specific disorders related to **vitamin D metabolism** or **bone health**. As always, it is crucial to consult a healthcare provider for precise dosing information, as overuse or misuse can lead to complications like **hypercalcemia**.

Renal Dose

In patients with **renal impairment**, **Calcifediol** should be used with caution. The dose may need to be adjusted based on kidney function. For individuals with **moderate renal dysfunction**, it is important to monitor **serum calcium** and **phosphate** levels regularly to avoid complications. - **Severe renal impairment**: In cases of significant kidney dysfunction, **Calcifediol** should be avoided, or its use should be closely monitored under the guidance of a healthcare provider. - **Dialysis patients**: Patients undergoing dialysis may need specific dose adjustments, and frequent monitoring of calcium and phosphate levels is essential.

Administration

Information not available