REMSIMA SC 120 mg/ ml Price

Overview

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Name

Strontium Renalate

Precaution

Before using **Strontium Renalate**, it is essential for patients to consult their healthcare provider, as this medication has specific precautions to be aware of: - **Kidney Disease**: Strontium Renalate is primarily used for its effects on bone metabolism. However, individuals with **renal impairment** should exercise caution. Renal function should be monitored closely, as strontium is eliminated through the kidneys, and impaired renal function could lead to a build-up of the drug in the body, increasing the risk of adverse effects. - **Pregnancy and Lactation**: Strontium Renalate is **contraindicated during pregnancy** because there is insufficient data regarding its safety in pregnant women. Strontium can potentially pass to the fetus and affect bone development. It is also not recommended during **lactation**, as it is unknown whether the drug passes into breast milk. Therefore, alternative treatments should be considered during these periods. - **Heart Disease**: Strontium Renalate should be used cautiously in individuals with **heart disease**, particularly those with a history of **cardiac arrhythmias**, since the drug has been linked to potential **cardiovascular events**. - **Calcium Disorders**: Strontium Renalate may interact with calcium metabolism, leading to **elevated calcium levels**. Patients with **hypercalcemia** or **hypocalcemia** should have their calcium levels monitored regularly while taking this medication. - **Concurrent Medications**: Strontium Renalate can interact with other medications, especially those affecting calcium metabolism or kidney function. Patients should disclose all medications, including over-the-counter drugs, supplements, and herbal remedies, to avoid potential harmful interactions.

Indication

Strontium Renalate is primarily prescribed for the management of **osteoporosis**, particularly in postmenopausal women and men with osteoporosis at high risk of fractures. Its indications include: - **Osteoporosis**: Strontium Renalate is approved to treat **osteoporosis** in patients at high risk of fractures, including those with low bone mineral density (BMD) and a history of fractures. The medication helps **increase bone mineral density** and reduce the **risk of fractures**, particularly in the spine and hip. - **Prevention of Fractures**: In individuals with osteoporosis, Strontium Renalate works by **enhancing bone strength** and helping to prevent fractures by improving the balance between **bone resorption** (breakdown) and **bone formation**. - **Postmenopausal Women**: It is especially beneficial for postmenopausal women who are at higher risk of developing osteoporosis due to **estrogen deficiency**. - **Men with Osteoporosis**: Strontium Renalate is also indicated for treating osteoporosis in men, particularly those with low BMD and a high risk of fractures.

Contra indication

Strontium Renalate should be avoided in the following conditions to ensure patient safety: - **Severe Renal Impairment**: Strontium Renalate is contraindicated in patients with **severe kidney disease** or **renal failure**, as the drug is primarily excreted through the kidneys, and impaired renal function may lead to toxic accumulation of the drug. - **Hypersensitivity**: If a patient has a known allergy or hypersensitivity to **strontium** or any other component in Strontium Renalate, it should not be used. - **Hypercalcemia or Hypocalcemia**: Strontium Renalate should not be used in patients with **abnormal calcium levels**, including **high calcium (hypercalcemia)** or **low calcium (hypocalcemia)**, unless closely monitored by a healthcare provider. - **Pregnancy and Lactation**: As previously mentioned, Strontium Renalate is contraindicated in **pregnancy** and **lactation** due to potential risks to the fetus and infant. - **Uncontrolled Heart Disease**: Patients with **uncontrolled heart disease** or **cardiovascular disease**, especially those with a history of **arrhythmias**, should avoid this medication due to its potential to affect heart function.

Side Effect

Strontium Renalate can cause side effects, some of which may require medical attention. Common and severe side effects include: - **Common Side Effects**: - **Gastrointestinal issues**: Nausea, vomiting, constipation, and diarrhea are possible. Taking the medication with food may help alleviate stomach upset. - **Headache**: A mild to moderate headache is reported in some patients. - **Fatigue**: Some individuals may feel unusually tired or experience fatigue while on this medication. - **Flu-like symptoms**: Some users may experience symptoms resembling the flu, such as **muscle pain**, **joint pain**, and **fever**. - **Serious Side Effects**: - **Cardiovascular Issues**: There have been concerns regarding an increased risk of **cardiovascular events**, including **heart attack** or **stroke**. Patients with a history of **heart disease** or **arrhythmias** should be monitored closely while on Strontium Renalate. - **Liver Dysfunction**: Strontium Renalate may cause **liver enzyme elevation**, indicating potential liver damage. Regular liver function tests should be conducted during treatment. - **Kidney Problems**: Although rare, **renal toxicity** can occur, particularly in patients with pre-existing kidney disease. Renal function should be monitored throughout treatment. - **Allergic Reactions**: Severe allergic reactions, such as **rash**, **swelling**, or difficulty breathing, can occur. Immediate medical attention is necessary if these occur.

Pregnancy Category ID

0

Mode of Action

Strontium Renalate is a **dual-action** medication that works through both **osteoblastic** (bone-building) and **osteoclastic** (bone-resorbing) mechanisms to improve bone health: - **Osteoblastic Activity**: Strontium Renalate stimulates the **osteoblasts** (bone-forming cells), promoting **bone formation** and increasing **bone density**. This reduces the risk of fractures by enhancing the strength of bones. - **Osteoclastic Inhibition**: It also inhibits **osteoclasts** (bone-resorbing cells), reducing **bone resorption** and the breakdown of bone tissue. By doing so, it helps maintain bone density and structure. - **Strontium** has been shown to integrate into bone tissue in place of calcium, promoting **bone mineralization** and improving bone mechanical properties.

Interaction

Strontium Renalate can interact with other drugs, potentially affecting its efficacy or causing harmful side effects. Notable interactions include: - **Calcium Supplements**: Strontium Renalate can interfere with calcium absorption. Patients should not take **calcium supplements** or **calcium-rich foods** close to the time of taking Strontium Renalate. There should be a gap of at least **2 hours** between taking calcium and this medication. - **Alendronate or Bisphosphonates**: Concurrent use of **bisphosphonates** (such as **alendronate**) may interfere with the effectiveness of Strontium Renalate, as both drugs affect bone turnover. Consult a healthcare provider before combining them. - **Antacids and Proton Pump Inhibitors (PPIs)**: Medications that **reduce stomach acid**, such as **antacids** or **PPIs** (e.g., **omeprazole**), can reduce the absorption of strontium. It is advised to avoid these drugs within a few hours of taking Strontium Renalate. - **Renal Impairment Medications**: Strontium Renalate can interact with **renal medications** that affect kidney function, such as **diuretics**. Monitoring of renal function is crucial if these medications are prescribed together. - **Other Osteoporosis Medications**: When combining with other treatments for osteoporosis, such as **denosumab**, **teriparatide**, or **raloxifene**, a healthcare provider must evaluate the potential interactions and adjust the treatment plan.

Pregnancy Category Note

Information not available

Adult Dose

The usual dose of **Strontium Renalate** for adults is **2 grams** (2000 mg) per day, taken in a single dose. This dosage should be followed strictly, and the medication is typically administered **with or without food**. Patients should follow their healthcare provider’s instructions regarding dosage and the best time to take the medication.

Child Dose

Strontium Renalate is **not approved** for use in **children** or **adolescents**. There is insufficient data regarding its safety and efficacy in pediatric patients, so it is not recommended for individuals under the age of **18 years**. As with any medication, it is critical to seek professional medical guidance before beginning Strontium Renalate to ensure the appropriate dosage and avoid potential interactions or side effects.

Renal Dose

Strontium Renalate is **not recommended** in patients with **severe renal impairment** (e.g., those with creatinine clearance less than 30 mL/min) because the drug is primarily excreted through the kidneys. In patients with **mild to moderate renal impairment**, the dose may need to be adjusted, and renal function should be monitored regularly throughout treatment.

Administration

Information not available