PURI-NETHOL 50mg Price

Overview

Welcome to Dwaey, specifically on PURI-NETHOL 50mg Tablets page.
This medicine contains an important and useful components, as it consists of Mercaptopurine.
PURI-NETHOL 50mg is available in the market in concentration 50mg/Tablet and in the form of Tablets.

EXCELLA GmbH is the producer of PURI-NETHOL 50mg and it is imported from GERMANY, The most popular alternatives of PURI-NETHOL 50mg are listed downward .

Mode Of Action

Mercaptopurine is a purine antagonist which is converted intracellularly into its active nucleotides, including thioinosinic acid. The nucleotides inhibit several reactions which ultimately interferes with nucleic acid synthesis and prevents the formation of RNA and DNA.

Indication

• Acute lymphatic leukaemia
• Crohn's disease

Precaution

Hepatic or renal dysfunction; monitor hepatic function periodically. Mercaptopurine is potentially carcinogenic. Thiopurine S-methyl transferase (TPMT) deficiency; porphyria. Lactation: not known if excreted in breast milk, do not nurse

Side Effects

• >10% Elevated LFT's (15%) 1-10% Nausea (10%)
• Vomiting (10%)
• Stomatitis (3-10%)
• Thrombocytopenia (3-10%)
• Rash (1-3%)
• Diarrhea (1-3%)
• Dizziness (1-3%)
• Alopecia (1-3%)
• Leukopenia (1-3%) Frequency Not Defined Fatigue
• Anorexia
• Headache
• Chills and fever
• Chest pain
• Mucositis
• Upper respiratory infection
• Cough
• Ulceration of intestine
• Ulcerative stomatitis
• Myelosuppressionm
• Decreased hematocrit
• Hepatotoxicity
• Decreased resistance to infections
• Hyperuricemia
• Nephrotoxicity
• Increased risk of pancreatitis in pts with IBD
• Hyperpigmentation of skin
• Arthralgias
• Eye discomfort
• Tinnitus Potentially Fatal: Myelosuppression; hepatotoxicity
• cholestatic jaundice.

Contra indication

Pregnancy and lactation. Prior resistance to mercaptopurine or thioguanine; severe liver disease; severe bone marrow suppression.

Pregnancy and lactation

Pregnancy category: D

There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.