PRIMOCEF 1g I.M. Price

Overview

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This medicine contains an important and useful components, as it consists of
Cefotaxime (as sodium)is available in the market in concentration

Name

Cefotaxime

Precaution

History of penicillin allergy; colitis; impaired renal function; pregnancy, lactation. Lactation: Drug enters breast milk; use with caution

Indication

Pneumonia, Meningitis, Peritonitis, Pelvic inflammatory disease, Endometritis, Pelvic cellulitis, Gonorrhea, Skin and skin structure infections, Respiratory tract infections, Urinary tract infections, Bacteremia/Septicemia, Bone and/or joint infections

Contra indication

Hypersensitivity to cephalosporins.

Side Effect

Colitis, Elevated blood urea nitrogen (BUN) and creatinine, Elevated hepatic transaminases, Fever. Pain at inj site; hypersensitivity reactions, rash, pruritus; diarrhoea, nausea, vomiting; candidiasis; eosinophilia, neutropenia, leucopenia, thrombocytopenia. Potentially Fatal: Anaphylactic reaction; nephrotoxicity.

Pregnancy Category ID

2

Mode of Action

Cefotaxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Interaction

Probenecid decreases cefotaxime elimination. Potentially Fatal: Nephrotoxicity with furosemide and aminoglycosides.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration