PREJAC 5% Price

Overview

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This medicine contains an important and useful components, as it consists of
Prilocaine/Lidocaineis available in the market in concentration

Name

Lidocaine + Prilocaine topical

Precaution

Caution when used over large areas and leaving on for >2 hr. Severe hepatic impairment. Caution when used in patients who are receiving class I and III antiarrhythmics. Dose reduction may be necessary in acutely ill, debilitated patients and elderly. Avoid using on open wounds or near the eyes. Pregnancy and lactation. Lactation: Excreted in breast milk; use not recommended

Indication

Local anaesthesia

Contra indication

Neonates with gestational age <37 wk. Infants <12 mth of age who are receiving treatment with methaemoglobin-inducing agents or children who are receiving medications associated with drug-induced methaemoglobinemia. Children with congenital or idiopathic methaemoglobinemia. Application on mucous membranes, broken or inflamed skin.

Side Effect

>10% Pallor/blanching (37%),Application site erythema/pain (30%),Genital mucous membrane burning sensation (17%),Oral cavity, periodontal formulation (15%) 1-10% Alterations in temperature sensations (7%),Application site edema (6-10%),Itching (2%) <1% Rash,Myocardial dysfunction (rare),Methemoglobinemia (rare),Depression/excitation (rare),Seizure (rare) Frequency Not Defined Localized discrete purpuric or petechial reactions (rare) Localized hyperpigmentation (rare) Allergic reactions (eg, urticaria, angioedema, bronchospasm, shock)

Pregnancy Category ID

2

Mode of Action

Lidocaine and prilocaine are local anaesthetic agents of the amide type. Both work by stabilising the neuronal membranes and inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby giving rise to the anaesthetic action.

Interaction

Increased risk of toxicity when used with drugs that are known to cause methaemoglobinaemia. Concurrent use with class III antiarrhythmics may lead to additive cardiac effects. Toxic effects may be additive when used with class I antiarrhythmics.

Pregnancy Category Note

Information not available

Adult Dose

Child Dose

Renal Dose

Administration