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Overview

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This medicine contains an important and useful components, as it consists of
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Name

Ofloxacin 0.3% E&E drops

Precaution

Before using **Ofloxacin 0.3% E&E drops** (ophthalmic solution), patients should consult with their healthcare provider to ensure the medication is appropriate for their condition. Some key precautions include: - **Hypersensitivity**: Ofloxacin ophthalmic drops should not be used by individuals with known **allergies** to **fluoroquinolone antibiotics** or any components of the formulation. Symptoms of hypersensitivity may include **swelling**, **rash**, **itching**, or **difficulty breathing**. - **Eye Disorders**: Caution should be taken when using these drops in patients with a history of **corneal disorders** or **ocular surgery**, as they may be more prone to adverse effects. - **Contact Lens Wearers**: Patients who wear **contact lenses** should remove them before using the drops, as the preservative **benzalkonium chloride** may be absorbed by the lenses and cause irritation or discoloration. Contact lenses should not be worn during the course of the treatment. - **Pregnancy and Lactation**: Ofloxacin 0.3% ophthalmic solution falls under **Category C** during pregnancy. It should be used only if necessary, and under the guidance of a healthcare provider. The drug is also excreted into breast milk in small amounts, so breastfeeding mothers should consult a doctor before use. - **Concomitant Use of Other Eye Medications**: Patients should consult their healthcare provider before using **multiple eye medications**. There may be a risk of drug interactions, and the timing of administration may need to be adjusted.

Indication

Ofloxacin 0.3% E&E drops are primarily prescribed for **bacterial eye infections**, including: - **Bacterial Conjunctivitis**: Used to treat **bacterial infection** of the conjunctiva, causing symptoms such as redness, swelling, and discharge. - **Corneal Ulcers**: These drops are also used to treat **infected corneal ulcers**, particularly those caused by **gram-negative** bacteria, which may cause severe damage to the cornea if left untreated. - **Blepharitis**: Ofloxacin 0.3% drops can be used to treat **infections of the eyelids**, caused by **bacteria**. - **Post-Surgical Infections**: In some cases, it is used after **eye surgery** (e.g., cataract surgery) to prevent **bacterial infections** in the eye. - **Other External Ocular Infections**: The drops are effective for treating other **superficial ocular infections** caused by susceptible organisms.

Contra indication

There are certain situations where Ofloxacin 0.3% ophthalmic solution should not be used: - **Hypersensitivity**: Ofloxacin 0.3% E&E drops are contraindicated in patients with a known **hypersensitivity** or **allergy** to the drug or any components of the formulation, including **benzalkonium chloride**. - **Viral or Fungal Infections**: These drops are not effective against **viral** or **fungal eye infections**. They should not be used for conditions such as **herpes simplex keratitis** or **fungal keratitis**. - **Severe Eye Injury**: In cases of **severe corneal injury** or **chemical burns**, other treatments may be more appropriate. - **Children**: While the drops may be used in pediatric patients, they should only be prescribed by a healthcare provider after assessing the risks and benefits for younger patients.

Side Effect

Though side effects from Ofloxacin 0.3% ophthalmic drops are generally rare and mild, patients should be aware of the following: - **Common Side Effects**: - **Eye irritation**: Temporary stinging or burning sensation may occur upon instilling the drops. - **Redness or discomfort** in the eye. - **Blurred vision**: This may occur immediately after applying the drops but usually resolves quickly. - **Serious Side Effects**: - **Hypersensitivity reactions**: Rarely, patients may experience **severe allergic reactions** like **swelling of the eyelids**, **itching**, or **rash**. - **Superinfection**: Prolonged use may lead to the growth of non-susceptible organisms, including fungi, resulting in a secondary infection. - **Corneal damage**: In some cases, improper use or overuse may result in damage to the **corneal surface**, leading to potential complications such as ulcers. - **Vision changes**: In rare cases, **vision disturbances** may occur, requiring a discontinuation of the drops. Patients should report any severe side effects, particularly signs of **infection** or **allergic reactions**, to their healthcare provider immediately.

Pregnancy Category ID

3

Mode of Action

Ofloxacin 0.3% ophthalmic solution is a **fluoroquinolone antibiotic** that works by inhibiting the action of two bacterial enzymes, **DNA gyrase** and **topoisomerase IV**. These enzymes are essential for bacterial **DNA replication** and **repair**: - By inhibiting these enzymes, Ofloxacin prevents the bacteria from replicating their DNA and repairing their damaged cellular structures, ultimately leading to **cell death**. - This action is effective against a wide range of **gram-negative** and **gram-positive** bacteria, particularly those responsible for **ocular infections**. - Ofloxacin is specifically effective in the **eye** and **corneal tissues**, where it is able to penetrate the ocular surface and exert its therapeutic effects.

Interaction

Ofloxacin 0.3% ophthalmic solution has minimal systemic absorption, which limits the risk of significant drug interactions. However, the following interactions should be noted: - **Topical Steroids**: Using Ofloxacin 0.3% E&E drops in combination with **topical corticosteroids** may increase the risk of **corneal perforation** and should be done cautiously. - **Other Ophthalmic Medications**: When used alongside other eye medications, the **timing** of administration may need to be spaced to avoid potential interactions. It is generally recommended to wait at least **5 minutes** between applying different eye drops. - **Antibiotics**: While Ofloxacin is an **antibiotic**, combining it with other antibiotics in an eye drop form is not usually recommended unless specified by a healthcare provider, as it can affect efficacy.

Pregnancy Category Note

Information not available

Adult Dose

The standard dosage for **adults** using Ofloxacin 0.3% ophthalmic drops is: - **Bacterial Conjunctivitis**: Instill **1-2 drops** of Ofloxacin 0.3% E&E ophthalmic solution into the **affected eye(s)** every **2 hours** during waking hours for the first two days, followed by **1-2 drops every 4 hours** for the remaining duration of the treatment. - **Corneal Ulcers**: Instill **1 drop** every **hour** during waking hours for the first 2 days, followed by **1 drop every 4 hours** until the infection resolves. - Treatment typically lasts for **7-10 days**, depending on the severity of the infection and the patient's response.

Child Dose

For pediatric patients, the use of **Ofloxacin 0.3% ophthalmic solution** should be carefully considered by a healthcare provider: - **Children (under 18 years)**: The typical dose is similar to that for adults. **1-2 drops** of Ofloxacin 0.3% should be instilled into the **affected eye(s)** every **2 hours** for the first 2 days, then reduced to **every 4 hours** for the remainder of the treatment period. However, pediatric use should be based on a physician’s recommendation.

Renal Dose

Ofloxacin 0.3% ophthalmic solution is applied topically to the eye, which results in minimal systemic absorption. As a result, **renal dosage adjustments** are not necessary for most patients, including those with **renal impairment**. However, patients with severe renal impairment should be monitored for any signs of systemic absorption and adverse effects, especially with prolonged use.

Administration

Information not available